Isoflurane based tranquilizing drug

A technology of calming the nerves and isoflurane, applied in the field of medicine, can solve problems such as malaise, sudden death, prolonging the time of apnea, etc., and achieve the effects of fast fading, avoiding pain, and fast hypnosis

Inactive Publication Date: 2017-11-28
SICHUAN CANCER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, insomnia and anxiety are usually relieved by oral stable drugs on the market, but stable drugs have a time lag, which will cause drowsiness, fatigue, listlessness, etc. during the day; more seriously, suffer from s

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  • Isoflurane based tranquilizing drug
  • Isoflurane based tranquilizing drug
  • Isoflurane based tranquilizing drug

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with test examples and specific embodiments.

[0026] Isoflurane, chemical name: 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether

[0027] Structural formula:

[0028]

[0029] Molecular formula: C3H2ClF5O

[0030] Molecular weight: 184.49

[0031] Physical and chemical properties: inhaled general anesthetic, isomer of enflurane. It is a transparent, colorless liquid, volatile; it is stable and does not decompose in soda lime. The specific gravity is 1.50 (25°C), the boiling point at standard atmospheric pressure is 48.5°C, and the saturated vapor pressure is 32kPa at 20°C; the gas / blood partition coefficient is 1.4, the cerebral blood partition coefficient is 4.0, and the MAC value is 1.15; the chemical properties of isoflurane are stable, It can be mixed with oxygen in any proportion, not easy to explode, and will not decompose when exposed to light or alkali.

[0032] Pharmacolog...

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Abstract

The invention relates to an isoflurane based tranquilizing drug. The isoflurane based tranquilizing drug includes a medicament and a drug carrier, wherein the medicament is isoflurane. The drug carrier comprises a water-absorbing material and a shell. The water-absorbing material is used for carrying isoflurane, and the shell is used for coating the water-absorbing material to avoid isoflurane volatilization. The shell is provided with an opening for volatilizing isoflurane at the opening in the treatment process, and the opening is provided with a sealing device. The isoflurane based tranquilizing drug provided by the invention is an inhaled drug accepted by breathing, has fast tranquilizing speed and small side effect, and the drug subsides quickly after taking effect, and does not affect the normal life and work of drug users. In addition, the isoflurane based tranquilizing drug has low bioconversion rate and minimal influence to liver and kidney functions, and is still suitable for patients with incomplete liver and kidney functions.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a sedative and tranquilizer based on isoflurane. Background technique [0002] With the gradual acceleration of the pace of life, the number of people who are often troubled by insomnia and anxiety is gradually increasing. At present, insomnia and anxiety are usually relieved by oral stable drugs on the market, but stable drugs have a time lag, which will cause drowsiness, fatigue, listlessness, etc. during the day; For insomniacs with apnea, because sleeping pills can prolong the time of apnea, sudden death may occur; at the same time, there is a problem that some patients are not suitable for oral tranquilizers or injection tranquilizers. Contents of the invention [0003] The purpose of the present invention is to provide a sedative and tranquilizer based on isoflurane, which can improve some disadvantages of current tranquilizers in relieving some mental diseases such as insomnia, ...

Claims

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Application Information

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IPC IPC(8): A61K31/08A61P25/20
CPCA61K31/08
Inventor 唐育民张可贤刘寅魏湘华舒进军
Owner SICHUAN CANCER HOSPITAL
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