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L-aspartic acid chelated calcium and preparation method thereof

A technology of aspartic acid and chelated calcium, which is applied in the field of calcium agents, can solve the problems of incomplete reaction, long time, and low yield, and achieve the effects of saving production costs, short reaction time, and high yield

Inactive Publication Date: 2017-12-01
王广生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, its preparation methods mainly include chemical synthesis and electrolysis-semipermeable membrane methods, but the main problems of these methods include: slow reaction, long time, low yield, incomplete reaction, and removal of the remaining reactions that do not participate in the synthesis It is more difficult to produce, therefore, it is more difficult to produce on a large scale

Method used

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Examples

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Effect test

preparation example Construction

[0022] The invention provides a kind of preparation method of L-aspartic acid chelated calcium, comprises the steps:

[0023] S1: Add calcium hydroxide and L-aspartic acid into water, and then homogeneously disperse; wherein, the molar ratio of calcium hydroxide and L-aspartic acid is 1: (1.5~2.5), calcium hydroxide and L - The ratio of the total mass of aspartic acid to the mass of water is 25:(70-80).

[0024] S2: adjust the pH value of the product obtained in S1 to 7.3-7.5, and then decolorize and filter to obtain a solution with a solid particle size of less than 30 μm;

[0025] S3: put the solution into the reaction kettle, and react at 95-105°C and 105-115MPa for 50-70min;

[0026] S4: Concentrate the product obtained in S3 to obtain a concentrated solution; reduce the pressure and temperature of the concentrated solution to obtain L-aspartic acid chelated calcium crystals; wherein, in the concentrated solution, the mass fraction of water is 10% to 15%; The pressure afte...

Embodiment 1

[0032] The present embodiment provides a kind of preparation method of L-aspartic acid chelated calcium, comprises the steps:

[0033] S1: Add calcium hydroxide and L-aspartic acid to water, and then homogeneously disperse; wherein, the molar ratio of calcium hydroxide and L-aspartic acid is 1:2, calcium hydroxide and L-aspartic acid The ratio of the total mass of acid to the mass of water is 25:75.

[0034] S2: adjust the pH value of the product obtained in S1 to 7.4, and then decolorize and filter to obtain a solution with a solid particle size of less than 30 μm;

[0035] S3: put the solution into the reactor, and react at 100°C and 110MPa for 60min;

[0036] S4: Concentrate the product obtained in S3 to obtain a concentrated solution; reduce the pressure and temperature of the concentrated solution to obtain L-aspartic acid chelated calcium crystals; wherein, in the concentrated solution, the mass fraction of water is 12%; The pressure is 50MPa, and the temperature after...

Embodiment 2

[0041] The present embodiment provides a kind of preparation method of L-aspartic acid chelated calcium, comprises the steps:

[0042] S1: Add calcium hydroxide and L-aspartic acid into water, and then homogeneously disperse; wherein, the molar ratio of calcium hydroxide and L-aspartic acid is 1:1.5, calcium hydroxide and L-aspartic acid The ratio of the total mass of acid to the mass of water is 25:70.

[0043] S2: adjust the pH value of the product obtained in S1 to 7.3, and then decolorize and filter to obtain a solution with a solid particle size of less than 30 μm;

[0044] S3: Put the solution into the reactor, and react at 95°C and 105MPa for 50min;

[0045] S4: Concentrate the product obtained in S3 to obtain a concentrated solution; reduce the pressure and temperature of the concentrated solution to obtain L-aspartic acid chelated calcium crystals; wherein, in the concentrated solution, the mass fraction of water is 10%; The pressure is 45MPa, and the temperature af...

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PUM

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Abstract

The invention relates to L-aspartic acid chelated calcium and a preparation method thereof. The preparation method comprises the following steps: adding calcium hydroxide and L-aspartic acid into water; then homogenizing and dispersing; regulating the pH (Potential of Hydrogen) value of a solution to be 7.3 to 7.5; then de-coloring and filtering to obtain a dissolved solution with the solid content granularity which is less than 30mu m; enabling the dissolved solution to react under pre-set temperature and pre-set pressure; then carrying out concentration to obtain a concentrated solution; depressurizing and cooling the concentrated solution to obtain an L-aspartic acid chelated calcium crystal; adding the L-aspartic acid chelated calcium crystal into water; then carrying out homogenization and dispersion and filtering treatment in sequence to obtain amino acid chelate clear liquid; then carrying out spray-drying treatment on the amino acid chelate clear liquid to obtain the L-aspartic acid chelated calcium. The invention provides a method for efficiently and rapidly producing amino acid chelate in a large scale; the reaction time can be shortened and the yield is improved; the purity of the prepared L-aspartic acid chelated calcium is high, and the production cost can be greatly reduced.

Description

technical field [0001] The invention relates to the technical field of calcium preparations, in particular to L-aspartic acid chelated calcium and a preparation method thereof. Background technique [0002] Calcium is the most abundant metal element in the human body. Under normal circumstances, the total calcium content in the adult body is about 120 grams, of which about 99% are distributed in bones and teeth, and the remaining 1% exists in cells in the form of free or combined ions. In external fluids, blood and soft tissues. Calcium is not only the main component of human bones and teeth, but also plays a role in the normal fluctuation of the heart, blood coagulation, conduction of normal excitability of muscles and nerves, maintenance of suitable induction, permeability of cell membranes, and various enzymes. The activity and other physiological functions play an important role. Calcium deficiency can cause various diseases, especially for infants, pregnant women and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C229/76C07C227/40A61K31/198A61K31/7016A61K31/702A61K31/715A61P19/02A61P25/20A61P19/00
CPCC07C227/18A61K31/198A61K31/7016A61K31/702A61K31/715C07C227/40C07C229/76A61K2300/00
Inventor 王广生
Owner 王广生
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