Use of isoquinoline derivatives for diabetic wound healing
A technology for wound healing and diabetes, applied in the field of isoquinoline derivatives, can solve the problems of difficult-to-prevent complications and no reported effects of isoquinoline derivatives
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[0041] 1. have the preparation of the compound of formula I of the present invention
[0042] Dopamine (1.6 g), 10 mL of methanol, 1 mL of 1N hydrochloric acid and 2 mL of 99% acetaldehyde were sequentially added into a 50 mL round bottom flask and stirred at room temperature for 6 hours. The concentrate obtained by concentration under reduced pressure was loaded onto a Lobar RP-18 column (size B, Merck) and eluted with 0.05% aqueous formic acid to provide pure norhyolinine (1.0 g) for 1H NMR.
[0043] Using ESI-TOF mass spectrometer and NMR spectrum analysis, the characteristic data of norhyrogynine are as follows:
[0044] 1H NMR (CD 3 OD,400MHz)δ6.63(1H,s),6.57(1H,s),4.30(1H,q,J=6.8Hz,H-1),3.40(1H,dt,J=12.6,5.6Hz,H a -3),3.20(1H,ddd,J=12.6,8.2,5.6Hz,H b -3),2.92(1H,ddd,J=16.8,8.2,5.8Hz,H a -4),2.80(1H,dt,J=16.8,5.6Hz,H b -4), 1.55 (3H, d, J=6.8Hz, Me-1); ESIMS: m / z 180 ([M+H] + ).
[0045] 2. Evaluation of the effect of norhyrogynine in the treatment of diabetic woun...
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