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Use of isoquinoline derivatives for diabetic wound healing

A technology for wound healing and diabetes, applied in the field of isoquinoline derivatives, can solve the problems of difficult-to-prevent complications and no reported effects of isoquinoline derivatives

Active Publication Date: 2017-12-01
ZIH YUAN TANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art references do not report the effect of isoquinoline derivatives on the treatment of diabetic wound healing
[0006] Diabetes mellitus is essentially harmless if controlled, but the state of abnormally high blood sugar levels associated with the condition can lead to certain serious complications
It is more difficult to prevent complications if left uncontrolled for a long time, or if people with diabetes cannot make lifestyle adjustments to manage the disease

Method used

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  • Use of isoquinoline derivatives for diabetic wound healing
  • Use of isoquinoline derivatives for diabetic wound healing
  • Use of isoquinoline derivatives for diabetic wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] 1. have the preparation of the compound of formula I of the present invention

[0042] Dopamine (1.6 g), 10 mL of methanol, 1 mL of 1N hydrochloric acid and 2 mL of 99% acetaldehyde were sequentially added into a 50 mL round bottom flask and stirred at room temperature for 6 hours. The concentrate obtained by concentration under reduced pressure was loaded onto a Lobar RP-18 column (size B, Merck) and eluted with 0.05% aqueous formic acid to provide pure norhyolinine (1.0 g) for 1H NMR.

[0043] Using ESI-TOF mass spectrometer and NMR spectrum analysis, the characteristic data of norhyrogynine are as follows:

[0044] 1H NMR (CD 3 OD,400MHz)δ6.63(1H,s),6.57(1H,s),4.30(1H,q,J=6.8Hz,H-1),3.40(1H,dt,J=12.6,5.6Hz,H a -3),3.20(1H,ddd,J=12.6,8.2,5.6Hz,H b -3),2.92(1H,ddd,J=16.8,8.2,5.8Hz,H a -4),2.80(1H,dt,J=16.8,5.6Hz,H b -4), 1.55 (3H, d, J=6.8Hz, Me-1); ESIMS: m / z 180 ([M+H] + ).

[0045] 2. Evaluation of the effect of norhyrogynine in the treatment of diabetic woun...

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Abstract

The present invention is related to a method for diabetic wound healing comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having the general Formula I, preferably salsolinol.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 291,193, filed February 5, 2016, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention provides a method for diabetic wound healing. Specifically, the present invention provides a novel use of isoquinoline derivatives for diabetic wound healing. Background technique [0004] Isoquinoline derivatives are a group of nitrogen-containing organic compounds that exist in plants and animals in nature. Most of them have a composite ring structure with nitrogen atoms incorporated into the ring. These isoquinoline derivatives (including norhyrogynine and arachicarline) have significant biological activity. It is known that norhyoculamine is mainly used to regulate blood pressure, while arcicarline is mainly used as an active ingredient in the treatment of malaria and also as a component of painkillers. [0005] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/472A61P3/10A61P17/02
CPCA61K31/472A61P17/02A61P3/10A61K9/0014A61K9/06A61K47/10Y02A50/30A61K31/47C07D217/00
Inventor 李水盛苏铭嘉叶集焕徐兆民
Owner ZIH YUAN TANG BIOTECH
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