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Compound snow lotus capsules as well as preparation method and device thereof

A compound snow lotus and preparation device technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of cumbersome preparation process, incomplete extraction, loss of aconitine, etc., so as to save human resources and Material resources, detection methods are simple, and the effect of improving accuracy

Active Publication Date: 2017-12-15
SINOPHARM GRP XINJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Aconitum aconitum and Aconitum aconitum contained in its medicinal materials contain aconitine, which is toxic. Therefore, the content of aconitine in the finished product of Compound Snow Lotus Capsules must be strictly controlled to avoid harm to the human body.
[0003] The existing detection method of aconitine is to detect the residual amount of aconitine in the finished product in compound snow lotus capsules through chemical extraction and separation. However, the detection method has the following defects: (1) there is an extraction process in the extraction process. Phenomena such as incompleteness and loss of aconitine lead to deviations in the test results, which affect the accuracy and reliability of the test results; (2) This test method is carried out after the preparation of Compound Snow Lotus Capsules is completed. If a product with aconitine exceeding the standard is found , can only discard the product, resulting in a waste of human resources and material resources
[0004] And, because among the 8 medicinal materials of the compound snow lotus capsule, some need to be extracted with ethanol, such as snow lotus, and some need to be decocted and extracted with water, such as making Chuanwu and making Caowu, etc., the prior art needs to adopt different methods The devices are extracted separately, and the preparation process is cumbersome

Method used

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  • Compound snow lotus capsules as well as preparation method and device thereof
  • Compound snow lotus capsules as well as preparation method and device thereof
  • Compound snow lotus capsules as well as preparation method and device thereof

Examples

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preparation example Construction

[0032] The invention provides a preparation method of compound snow lotus capsule.

[0033] The preparation method of the compound snow lotus capsule provided by the invention comprises: decocting the first raw material of the compound snow lotus capsule with water, filtering, and concentrating to obtain a clear paste. Chuanwu, Zhicaowu and Xiangjiapi, the second raw material of the compound snow lotus capsules is extracted with ethanol, and after filtering, the extract is obtained. The second raw material is Tianshan snow lotus, and the described extract and the clear The pastes were mixed, allowed to stand, concentrated, dried, crushed, sieved, and packed into capsules to obtain the compound snow lotus capsules. Quails were used to detect the toxicity of aconitine in Aconitum aconitum and Aconitum aconitum.

[0034] The preparation method of the compound snow lotus capsule provided by the invention starts from raw materials and adopts a detection method of biological test ma...

Embodiment 1

[0053] This embodiment provides a compound snow lotus capsule and its preparation method and device.

[0054] The raw materials and dosage of compound snow lotus capsules provided in this example are as follows: 720g snow lotus capsules, 180g vinegar corydalis, 180g notopterygium, 180g solitary, 180g papaya, 60g Zhichuanwu, 60g Zhicaowu, 240g Xiangjiapi.

[0055] Among them, the toxicity of aconitine in the following different batches of Aconitum and Aconitum was tested by quail feeding method, see Table 1.

[0056] Table 1 Aconitum and / or Aconitum powder in different tests

[0057]

[0058] Experiment 1 and Experiment 2 are performed first. If the quails in Test 1 were poisoned, then Test 3 and Test 4 were performed; if the quail in Test 2 were poisoned, then Test 5 and Test 6 were performed.

[0059] The quail feeding method that present embodiment provides is:

[0060] Experimental group: Grind the above-mentioned batches of Aconitum aconitum and / or Aconitum aconitum ...

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Abstract

The invention relates to compound snow lotus capsules as well as a preparation method and device thereof. The preparation method of the compound snow lotus capsules comprises the following steps: first raw materials including vinegar processed rhizoma corydalis, rhizoma et radix notopterygii and the like of the compound snow lotus capsules are decocted with water and filtered, and clear paste is obtained after concentration; a second raw material, namely, herba saussureae involucratae, of the compound snow lotus capsules is extracted with ethanol and filtered, and an extract solution is obtained; the extract solution and the clear paste are mixed, the mixture is left to stand and concentrated, then drying, smashing, sieving and encapsulating are performed, and the compound snow lotus capsules are obtained. Toxicity of aconitine in radix aconiti preparata and radix aconiti kusnezoffii preparata is detected with quail. According to the preparation method of the compound snow lotus capsules, the toxicity of the aconitine in the radix aconiti preparata and the radix aconiti kusnezoffii preparata is detected with a biological test material, a detection result is accurate and reliable, and the safety of the compound snow lotus capsules is improved.

Description

technical field [0001] The invention relates to a compound snow lotus capsule, in particular to a preparation method and a device for the compound snow lotus capsule. Background technique [0002] Compound Snow Lotus Capsule is a traditional Chinese medicine compound preparation made from 8 medicinal materials such as Snow Lotus, Corydalis Corydalis, Aconitum Aconitum, and Aconitum Aconitum. Good medicine for treating rheumatic diseases. However, Aconitine and Aconitum contained in its medicinal materials contain aconitine, which is toxic. Therefore, it is necessary to strictly control the content of aconitine in the finished product of Compound Snow Lotus Capsules, so as not to cause harm to the human body. [0003] The existing detection method of aconitine is to detect the residual amount of aconitine in the finished product in compound snow lotus capsules through chemical extraction and separation. However, the detection method has the following defects: (1) there is an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A61K9/48A61P29/00A01K67/02A23K50/70A23K10/30A61J3/07
CPCA01K67/02A23K10/30A23K50/70A61J3/07A61K9/4841A61K36/232A61K36/237A61K36/27A61K36/285A61K36/66A61K36/714A61K36/732A61K2236/33A61K2236/331A61K2236/51A61K2300/00
Inventor 王歆君汪阳杨帆倪爽爽张文文
Owner SINOPHARM GRP XINJIANG PHARMA
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