Multi-channel microfluidic chip apparatus for simultaneously detecting multiple subtype swine influenza

A microfluidic chip and swine flu technology, applied in the field of analysis and testing, can solve the troublesome operation of modifying the inner surface of the PDMS channel, which has not been properly solved, and the difficulty of passing fine liquid flow.

Inactive Publication Date: 2017-12-19
李榕生
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] But it's not that simple
[0008] First, this polydimethylsiloxane material, which is referred to by the acronym PDMS, is itself a strongly hydrophobic material, and channels are built on this material. modification operation, then, after the overall assembly is completed, that is, after the cover is covered, because the inner surface of the channel in the structure occupies most of the inner surface of the liquid flow channel, then the inner surface of the PDMS channel is The strong hydrophobicity is the decisive factor, it will make it very difficult for the polar liquid fine flow similar to the aqueous solution to pass through, and its flow resistance is so large that even the general micropump is difficult to push, of course, if the cover sheet is also If you choose to use the PDMS material, then the problems are basically the same, with minor differences; therefore, in the prior art, it is necessary to modify and modify the inner surface of the channel on the PDMS material; then, this is for the PDMS channel Is the modification operation of the inner surface of the channel very troublesome? That's not the problem. What constitutes a serious technical problem is another problem: the PDMS polymer molecules in the bulk phase of the PDMS material substrate have the characteristics of automatic diffusion and migration to the surface. The characteristics of polymer molecules diffusing and migrating to the surface automatically will make the modified state of the inner surface of the channel modified by the surface unable to maintain for a long enough time. The maintenance time of the internal surface state is roughly only enough to complete the time required for the internal test experiment in the laboratory; in other words, the surface state of the PDMS channel inner surface after surface modification or surface modification is formed after modification It cannot last for a long time, but it will automatically tend to or change back to the surface state before the surface modification, and return to the original strongly hydrophobic surface state in a short period of time. Then, just imagine, such a slight Can flow control chips be produced in large quantities, stored in large quantities, and widely promoted? The answer is obvious, that is, impossible
This problem has also existed for many years, and so far, it has not been properly solved

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  • Multi-channel microfluidic chip apparatus for simultaneously detecting multiple subtype swine influenza

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Embodiment Construction

[0067] exist figure 1 In the illustrated embodiment of the present case, the structure of the microfluidic device includes a multi-channel microfluidic chip, and the structure of the microfluidic chip includes a substrate and a cover that are attached to each other and installed together. The substrate and the cover sheet are plates or sheets, the surface of the substrate facing the cover sheet contains a channel structure formed by a molding process or an etching process, and the substrate also contains a channel structure connected to the channel structure and The window structure is formed through the molding process, etching process or simple drilling process through the substrate, and the substrate and the cover are installed together to form a pipe structure and a liquid pool connected to it. structure of the microfluidic chip, the structural position of the pipeline is located in the interface area where the substrate and the cover are attached to each other, one side o...

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Abstract

The invention relates to a multi-channel microfluidic chip apparatus for simultaneously detecting multiple subtype swine influenza, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing subtype swine influenza has a series of practical problems that the surface of the PDMS material is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

Description

technical field [0001] The invention relates to a multi-channel microfluidic chip device for simultaneous detection of multiple subtypes of swine influenza. The microfluidic device is a special device for diagnosing subtype swine influenza antigens based on antigen / antibody specific reactions, and belongs to the field of analysis and testing. . Background technique [0002] For the technical background of multi-channel microfluidic subtype swine influenza diagnosis, please refer to CN 201110311127.1 and other invention patent applications. [0003] As far as the overall overview of microfluidic technology itself is concerned, you can refer to the monograph "Illustrated Microfluidic Chip Laboratory" published by the famous microfluidic expert Mr. Lin Bingcheng not long ago, which has been published by Science Press. The past, present, and future prospects of microfluidic technology, etc., have detailed and long-form discussions that go deep into specific details. [0004] S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N27/26G01N27/327G01N33/569
CPCB01L3/5027B01L2200/10G01N27/26G01N27/3275G01N33/56983
Inventor 李榕生
Owner 李榕生
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