49results about How to "Long-lasting superhydrophilic properties" patented technology

The present invention relates to a microfluidic chip apparatus for multi-channel simultaneous detection of six typical tumor markers, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for multi-channel simultaneous detection of six typical tumor markers has a series of problems that the surface of the PDMS is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The invention relates to a low-cost microfluidic device for syphilis diagnosis, which uses interface characteristics to transmit liquid flow, and belongs to the field of analysis and testing. There are some difficulties in using cheap and easy-to-process polydimethylsiloxane (PDMS) to make the substrate of the microfluidic chip for syphilis diagnosis; The interior is filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide particles that can induce super-hydrophilic properties on the surface through pre-irradiation of visible light; the titanium dioxide particles fill the super-hydrophilic gaps between the particles Collect, compensate, and surpass the original strong hydrophobic pipeline, thereby achieving a constant and super-hydrophilic modification effect; at the same time, a small power ultrasonic wave induces a difference in interfacial tension at both ends of the chip, which in turn promotes The sample liquid flows along the channel of the chip toward the terminal.

The present invention relates to an inexpensive cholera diagnosis microfluidic apparatus with a tortuous liquid flow transmission route, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for cholera diagnosis has a series of problems that the surface of the PDMS is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The invention relates to a universal micro-fluidic chip device for simultaneously detecting various tumor markers and belongs to the field of analytical test. Firstly, a series of problems are required to be solved if a substrate of a universal micro-fluidic chip for combined detection of more than ten tumor markers is produced by using PDMS, namely polydimethylsiloxane. The scheme has the key points that the substrate is made of PDMS with an original ecological surface, and a pipeline of the chip is filled with doped micrometer titanium dioxide particles; the surface super-hydrophilicity of the titanium dioxide particles can be induced by preliminary visible light irradiation; the set of super-hydrophilic slot channels among particles of titanium dioxide particle filler compensates and exceeds that of the original strongly-hydrophobic pipeline, and therefore, a constant and super-hydrophilic modification effect is achieved; and meanwhile, a difference of interfacial tensions is induced from the head and tail ends of the chip by using micro-power ultrasonic waves, and therefore, a sample liquid flow is guided to flow towards a terminal along the pipeline of the chip.

The invention relates to an acquired immunodeficiency syndrome diagnosis microfluidic apparatus with a specific fluid channel, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing acquired immunodeficiency syndrome is the technical target that the surface of the PDMS is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The present invention relates to an inexpensive microfluidic apparatus used for diagnosing cholera and using a hard modified interface to reduce flow resistance, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing cholera has a series of problems that the surface of the PDMS is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The invention relates to a micro-fluidic chip device for combined detection of female typical tumor markers and belongs to the field of analytical test. A series of problems are required to be solvedif a substrate of a micro-fluidic chip for combined detection of the female typical tumor markers is produced by using PDMS, namely polydimethylsiloxane. The scheme has the key points that the substrate is made of PDMS with an original ecological surface, and a pipeline of the chip is filled with doped micrometer titanium dioxide particles; the surface super-hydrophilicity of the titanium dioxideparticles can be induced by preliminary visible light irradiation; the set of super-hydrophilic slot channels among particles of titanium dioxide particle filler compensates and exceeds that of the original strongly-hydrophobic pipeline, and therefore, a constant and super-hydrophilic modification effect is achieved; and meanwhile, a difference of interfacial tensions is induced from the head andtail ends of the chip by using micro-power ultrasonic waves, and therefore, a sample liquid flow is guided to flow towards a terminal along the pipeline of the chip.

The invention relates to a microfluidic device for syphilis diagnosis with easily disassembled accessories for liquid flow drive, belonging to the field of analysis and testing. It is a technical goal to use cheap and easy-to-process polydimethylsiloxane (PDMS) to make the substrate of the microfluidic chip for syphilis diagnosis. The main point of this case is that the substrate is made of PDMS with an original ecological surface, and the pipes of the chip are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide that can induce superhydrophilic properties on the surface through pre-irradiation of visible light Particles; the collection of super-hydrophilic gaps between the particles of the titanium dioxide particle filler compensates and surpasses the original strong hydrophobic channels, thereby achieving a constant and super-hydrophilic modification effect; at the same time, with a small power The ultrasonic wave induces a difference in interfacial tension at both ends of the chip, thereby guiding the sample liquid to flow along the channel of the chip toward the terminal.

The invention relates to a micro-fluidic chip device for combined detection of male typical tumor markers and belongs to the field of analytical test. A series of problems are required to be solved ifa substrate of a micro-fluidic chip for combined detection of the male typical tumor markers is produced by using polydimethylsiloxane, namely PDMS. The scheme has the key points that the substrate is made of PDMS with an original ecological surface, and a pipeline of the chip is filled with doped micrometer titanium dioxide particles; the surface super-hydrophilicity of the titanium dioxide particles can be induced by preliminary visible light irradiation; the set of super-hydrophilic slot channels among particles of titanium dioxide particle filler compensates and exceeds that of the original strongly-hydrophobic pipeline, and therefore, a constant and super-hydrophilic modification effect is achieved; and meanwhile, a difference of interfacial tensions is induced from the head and tailends of the chip by using micro-power ultrasonic waves, and therefore, a sample liquid flow is guided to flow towards a terminal along the pipeline of the chip.

The invention relates to a device for detecting subtype swine influenza from which a fluid-driven member can be quickly removed, and belongs to the field of analysis and testing. There are many obstacles in using cheap and easy-to-process polydimethylsiloxane (PDMS) to make the substrate of the microfluidic chip for subtype swine influenza diagnosis. The main point of this case is that the substrate material is PDMS with an original ecological surface, and the chip’s pipes are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide that can induce superhydrophilic properties on its surface by pre-irradiation of visible light Particles; the collection of super-hydrophilic gaps between the particles of the titanium dioxide particle filler compensates and surpasses the original strong hydrophobic channels, thereby achieving a constant and super-hydrophilic modification effect; at the same time, with a small power The ultrasonic wave induces a difference in interfacial tension at both ends of the chip, thereby guiding the sample liquid to flow along the channel of the chip toward the terminal.

The invention relates to an inexpensive microfluidic device for syphilis diagnosis based on the principle of rigid interface modification, which belongs to the field of analysis and testing. It is a technical goal to use cheap and easy-to-process polydimethylsiloxane (PDMS) as the substrate of the microfluidic chip for syphilis diagnosis; the surface of PDMS is strongly hydrophobic, and the effect of surface chemical modification is difficult to last. The main point of this case is that the substrate is made of PDMS with an original ecological surface, and the pipes of the chip are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide that can induce superhydrophilic properties on the surface through pre-irradiation of visible light Particles; the collection of super-hydrophilic gaps between the particles of the titanium dioxide particle filler compensates and surpasses the original strong hydrophobic pipeline, thereby achieving a constant and super-hydrophilic modification effect; the titanium dioxide filler The function also includes preventing the chip from collapsing and deforming the pipeline, and preventing biological macromolecules from contacting the inner wall of the pipeline.

The present invention relates to a universal microfluidic chip apparatus for simultaneous detection of multiple tumor markers, and belongs to the field of analytical testing. According to the present invention, the use of PDMS to produce the substrate of a universal microfluidic chip for combined detection of more than ten kinds of typical tumor markers has a series of problems that the surface of the PDMS is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The invention relates to a chip device for combined typical tumor marker examination of female physical examination screening and belongs to the field of analysis and testing. Several problems is required to be solved by taking PDMS (polydimethylsiloxane) to prepare a substrate of a micro-fluidic chip for combined detection of eight typical tumor markers applicable to females. The device has the characteristics that the substrate is made from PDMS with an original ecological surface; a pipeline of the chip is filled with micron-sized titanium dioxide particles; the titanium dioxide particles can be irradiated by preliminary visible light; the visible light is induced from the surfaces of the particles; the titanium dioxide particles have super hydrophilicity; a set of interparticle super-hydrophilic gaps of titanium dioxide particle filling compensates and surpasses the original strongly hydrophobic pipeline; a constant and super-hydrophilic modification effect is achieved; and at thesame time, micropower ultrasonic waves induce an interfacial tension difference at the head end and the tail end of the chip to guide sample liquid to flow to a terminal along the pipeline of the chip.

The invention relates to a multi-channel microfluidic chip apparatus for simultaneously detecting multiple subtype swine influenza, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing subtype swine influenza has a series of practical problems that the surface of the PDMS material is strongly hydrophobic and the surface chemical modification effect is difficult to last. The technical scheme of the present invention is that the substrate material is PDMS with an original ecological surface, the pipeline of the chip is filled with doped micron-scale titanium dioxide particles, the surface super-hydrophilicity of the titanium dioxide particles can be induced by visible light irradiation in advance, and the set of the titanium dioxide particle filler and the super-hydrophilic gap between the particles can compensate and beyond the original strong hydrophobic pipeline, such that the constant and super hydrophilic modification effect is achieved. In addition, the titanium dioxide filler can further be used for preventing the pipeline of the chip from collapsing and deforming, and blocking biological macromolecules from contacting the inner wall of the pipeline.

The invention relates to a microfluidic chip device for detecting various tumor markers (TMs) by using fifteen channels in a combined manner, and belongs to the field of analysis and testing. When polydimethylsiloxane (PDMS) is used to manufacture a substrate of a universal microfluidic chip used for combined detection of more than ten tumor markers, a plurality of difficult problems need to be overcome. Key points of the scheme are as follows: PDMS with an original ecological surface is used as a substrate material, and the interiors of pipelines of the chip are filled with doped micron-sizedtitanium dioxide particles; the titanium dioxide particles have super-hydrophilic surfaces, and the super-hydrophilic surfaces can be formed by inducing of preliminary visible light irradiation; aggregation of super-hydrophilic gap channels among the particles of the titanium dioxide particle filler replaces, compensates and exceeds original strong-hydrophobic pipelines, and therefore constant and super-hydrophilic modification effects are achieved; and a difference of interfacial tension is formed between head and tail ends of the chip by inducing of micro-power supersonic waves, and therefore sample liquid flows are guided to flow towards a tail-end direction of the chip along the pipelines of the chip.

The invention relates to a low-cost microfluidic device for syphilis diagnosis based on a novel liquid flow driving principle, which belongs to the field of analysis and testing. It is a technical goal to use cheap and easy-to-process polydimethylsiloxane (PDMS) as the substrate of the microfluidic chip for syphilis diagnosis; however, there are some difficult problems. The main point of this case is that the substrate is made of PDMS with an original ecological surface, and the pipes of the chip are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide that can induce superhydrophilic properties on the surface through pre-irradiation of visible light Particles; the collection of super-hydrophilic gaps between the particles of the titanium dioxide particle filler compensates and surpasses the original strong hydrophobic channels, thereby achieving a constant and super-hydrophilic modification effect; at the same time, with a small power The ultrasonic wave induces a difference in interfacial tension at the first and last ends of the chip, and then promotes the flow of the sample liquid along the channel of the chip to the direction of the terminal.

The invention relates to a compact chip device convenient to assemble and disassemble and used for combined detection of typical tumor markers (TMs), and belongs to the field of analysis and testing.When polydimethylsiloxane (PDMS) is used to manufacture a substrate of a microfluidic chip used for multi-channel combined detection of typical tumor markers, a series of difficult problems which needto be overcome exist. Key points of the technical scheme are as follows: PDMS with an original ecological surface is used as a substrate material, and the interiors of pipelines of the chip are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles have super-hydrophilic surfaces, and the super-hydrophilic surfaces can be formed by inducing of preliminary visible light irradiation; aggregation of super-hydrophilic gap channels among the particles of the titanium dioxide particle filler replaces, compensates and exceeds original strong-hydrophobic pipelines,and therefore constant and super-hydrophilic modification effects are achieved; and a difference of interfacial tension is formed between head and tail ends of the chip by inducing of micro-power supersonic waves, and therefore sample liquid flows are guided to flow towards a tail-end direction along the pipelines of the chip.

The invention relates to a low-cost microfluidic device for AIDS diagnosis which transmits liquid flow in a new way, and belongs to the field of analysis and testing. There are technical obstacles in making the substrate of the microfluidic chip for AIDS diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The main point of this case is that the substrate is made of PDMS with an original ecological surface, and the pipes of the chip are filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles are titanium dioxide that can induce superhydrophilic properties on the surface through pre-irradiation of visible light Particles; the collection of super-hydrophilic gaps between the particles of the titanium dioxide particle filler compensates and surpasses the original strong hydrophobic channels, thereby achieving a constant and super-hydrophilic modification effect; at the same time, with a small power The ultrasonic wave induces a difference in interfacial tension at the first and last ends of the chip, and then promotes the flow of the sample liquid along the channel of the chip to the direction of the terminal.

The invention provides a method for realizing persistent super-hydrophilicity of a sapphire surface, which comprises the following steps of: S1, ablating the sapphire surface by femtosecond laser to form a periodic micron-sized notch groove structure on the sapphire surface and generate hydrophilic gamma-phase aluminum oxide at the same time; s2, spin-coating a titanium dioxide precursor solution on the sapphire surface of the formed micron-sized notch groove structure and the gamma-phase aluminum oxide; and S3, after the titanium dioxide precursor solution is dried, putting the sapphire into a muffle furnace, and carrying out high-temperature annealing, so that the lasting super-hydrophilicity of the surface of the sapphire is realized. The femtosecond laser is combined with the anatase type titanium dioxide crystal coating, the contact angle between the sapphire surface and water can be 0 degree, and the contact angle can be kept for more than 180 days in the super-hydrophilic state.

The invention relates to an easily disassembled cholera diagnosis device for liquid flow driving through interfacial characterization and belongs to the field of analysis testing. A series of difficulties can be resulted if polydimethylsiloxane, namely PDMS, which is low in price and very easy to process, is adopted to manufacture a cholera diagnosis micro-fluidic chip. The scheme of the invention is characterized in that PDMS with an original ecological surface is adopted as a substrate material, the channels of the chip are filled with doped micron-order titanium dioxide granules, super-hydrophilicity properties of the surfaces of the titanium dioxide granules can be induced by preset visible light, sets of super-hydrophilic gaps and channels of the titanium dioxide granules substitute and exceed original super-hydrophilic channels, and thus a constant and super-hydrophilic modification effect is achieved; meanwhile, differences of interfacial tension are induced from the head end and the tail end of the chip by using ultrasonic waves with micro power, and thus a test sample liquid is guided to flow to a terminal direction along the channels of the chip.

Belonging to the field of analytical test, the invention relates to a cholera diagnosis microfluidic device with a quickly dismountable sample liquid driving component. A series of problems exist in making substrates of microfluidic chips for cholera diagnosis from cheap and easily processable polydimethylsiloxane (PDMS). The invention has the key points that: the substrate is made of PDMS with anoriginal ecological surface, the pipeline of the chip is filled with doped micron-sized titanium dioxide particles; the surface super-hydrophilic properties of the titanium dioxide particles can be induced through visible light irradiation in advance; the super-hydrophilic gap set among the particles of the titanium dioxide particular filler substitutes and surpasses the originally strong hydrophobic pipeline, thereby achieving a constant and super-hydrophilic modification effect. At the same time, micropower ultrasonic wave is employed to induce the interfacial tension difference at the headand tail ends of the chip, thus guiding a sample liquid to flow along the pipeline to a terminal direction.

The invention relates to a micro-fluidic chip device for multichannel simultaneous detection of six typical tumor markers and belongs to the field of analytical test. A series of problems are requiredto be solved if a substrate of a micro-fluidic chip for multichannel combined detection of the six typical tumor markers is produced by using polydimethylsiloxane, namely PDMS. The scheme has the keypoints that the substrate is made of PDMS with an original ecological surface, and a pipeline of the chip is filled with doped micrometer titanium dioxide particles; the surface super-hydrophilicityof the titanium dioxide particles can be induced by preliminary visible light irradiation; the set of super-hydrophilic slot channels among particles of titanium dioxide particle filler compensates and exceeds that of the original strongly-hydrophobic pipeline, and therefore, a constant and super-hydrophilic modification effect is achieved; and meanwhile, a difference of interfacial tensions is induced from the head and tail ends of the chip by using micro-power ultrasonic waves, and therefore, a sample liquid flow is guided to flow towards a terminal along the pipeline of the chip.