Chip device for combined typical tumor marker examination of female physical examination screening

A tumor marker and screening technology, applied in the field of analysis and testing, can solve the problems of difficulty in passing fine liquid flow, has not been properly solved, and large flow resistance.

Inactive Publication Date: 2018-01-12
李榕生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] But it's not that simple
[0009] First, this polydimethylsiloxane material, which is referred to by the acronym PDMS, is itself a strongly hydrophobic material, and channels are built on this material. modification operation, then, after the overall assembly is completed, that is, after the cover is covered, because the inner surface of the channel in the structure occupies most of the inner surface of the liquid flow channel, then the inner surface of the PDMS channel is The strong hydrophobicity is the decisive factor, it will make it very difficult for the polar liquid fine flow similar to the aqueous solution to pass through, and its flow resistance is so large that even the general micropump is difficult to push, of course, if the cover sheet is also If you choose to use the PDMS material, then the problems are basically the same, with minor differences; therefore, in the prior art, it is necessary to modify and modify the inner surface of the channel on the PDMS material; then, this is for the PDMS channel Is the modification operation of the inner surface of the channel very troublesome? That's not the problem. What constitutes a serious technical problem is an

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  • Chip device for combined typical tumor marker examination of female physical examination screening

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Embodiment Construction

[0076] exist figure 1In the example shown in this case, the main point of this example is that the structure of the device includes a multi-channel microfluidic chip, and the structure of the microfluidic chip includes a substrate 8 and a cover sheet 7 that are attached to each other. , the substrate 8 and the cover sheet 7 are both plates or sheets, and the side of the substrate 8 facing the cover sheet 7 contains a channel structure formed by a molding process or an etching process. 8 also contains a window structure connected to the channel structure and pierced through the substrate 8 through a molding process, an etching process or a simple punching process. A microfluidic chip containing a pipeline structure and a liquid pool structure connected to it is constructed. The structure of the pipeline is located in the interface area where the substrate 8 and the cover sheet 7 are attached to each other. One side of the window is covered by the cover The sheet 7 is blocked a...

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Abstract

The invention relates to a chip device for combined typical tumor marker examination of female physical examination screening and belongs to the field of analysis and testing. Several problems is required to be solved by taking PDMS (polydimethylsiloxane) to prepare a substrate of a micro-fluidic chip for combined detection of eight typical tumor markers applicable to females. The device has the characteristics that the substrate is made from PDMS with an original ecological surface; a pipeline of the chip is filled with micron-sized titanium dioxide particles; the titanium dioxide particles can be irradiated by preliminary visible light; the visible light is induced from the surfaces of the particles; the titanium dioxide particles have super hydrophilicity; a set of interparticle super-hydrophilic gaps of titanium dioxide particle filling compensates and surpasses the original strongly hydrophobic pipeline; a constant and super-hydrophilic modification effect is achieved; and at thesame time, micropower ultrasonic waves induce an interfacial tension difference at the head end and the tail end of the chip to guide sample liquid to flow to a terminal along the pipeline of the chip.

Description

technical field [0001] The invention relates to a chip device for combined detection of typical tumor markers aimed at female physical examination and screening, and belongs to the field of analysis and testing. Background technique [0002] Tumor markers (tumor markers, TM) refer to a class of substances produced by tumor cells themselves or produced by the body's response to tumor cells during the occurrence and proliferation of tumors, reflecting the existence and growth of tumors, including Proteins, hormones, enzymes (isoenzymes) and oncogene products, etc. Testing the tumor markers in the patient's blood or body fluids can detect tumors early in the tumor screening, observe the curative effect of tumor treatment and judge the prognosis of patients. Currently, the tumor markers commonly used clinically are: (1) alpha-fetoprotein (AFP) is a marker for primary liver cancer, testicular cancer, ovarian cancer and other tumors; (2) carcinoembryonic antigen (CEA) is a marker...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N27/48
Inventor 李榕生
Owner 李榕生
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