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Recombinant human hyaluronic acid composition and application thereof in cosmetics

A technology of human hyaluronidase and hyaluronic acid, applied in the field of daily chemical industry, can solve the problems of difficult to promote collagen and elastic fibers to be smooth and elastic, unable to play their role, penetration to accelerate diffusion and absorption, etc. Mucosal infection and inflammatory response, recovery of self-cleaning and self-purification ability, and inhibition of inflammatory stimulation

Inactive Publication Date: 2017-12-22
海盾医美科技(杭州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing sources of hyaluronic acid, animal extraction methods have limited raw materials and low hyaluronic acid content in raw materials, resulting in low yield, difficult purification, high cost, poor product quality, and difficult to scale production; biological fermentation The extraction method adopts a long fermentation cycle, low relative molecular weight of the product, high protein content, low glucuronic acid content, poor light transmittance of the product, and some even show a fibrous form, which is not easy to dissolve and cannot be applied. It is used in the production of cosmetics; the hyaluronic acid obtained by the method of treating ordinary macromolecular hyaluronic acid with hyaluronidase of animal structure has not been processed by recombinant human hyaluronidase, and has lost the activity of recombinant human hyaluronic acid
[0004] Ordinary hyaluronic acid added to existing cosmetic ingredients has a single effect
Not only can it not promote the secretion of functional ingredients in the skin and mucous membranes, it is difficult to restore the original smoothness and elasticity of collagen and elastic fibers; it is also difficult to make the effective substances in the cosmetic components penetrate into the cells and accelerate the diffusion and absorption, and it cannot play the role of the effective substances in the cosmetics. Efficacy

Method used

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  • Recombinant human hyaluronic acid composition and application thereof in cosmetics
  • Recombinant human hyaluronic acid composition and application thereof in cosmetics
  • Recombinant human hyaluronic acid composition and application thereof in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] facial care formulations

[0045] (1) recombinant human hyaluronic acid composition solution (weight ratio)

[0046] Recombinant human hyaluronic acid 1.0%, plant compound 10.0%, skin conditioner 5.0%, add deionized water to 100.

[0047] (2) Recombinant human hyaluronic acid composition conditioning spray (weight ratio)

[0048] Recombinant human hyaluronic acid 0.1%, plant compound 0.5%, skin conditioner 10.0%, betaine 1.0%, glycerol polyether-26 2.0%, dipotassium glycyrrhizinate 0.1%, oat β-glucan 0.2%, 0.3% p-hydroxyacetophenone, 0.3% 1,2-hexanediol, 0.1% PEG-40 hydrogenated castor oil, 0.015% potassium hydroxide, 0.05% disodium EDTA, add deionized water to 100.

[0049] (3) Recombinant human hyaluronic acid composition facial mask (weight ratio)

[0050] Recombinant Human Hyaluronic Acid 0.5%, Plant Compound 5.0%, Skin Conditioner 8.0%, Glycerin 5.0%, Butylene Glycol 3.0%, Pentylene Glycol 1.5%, Polyethylene Glycol-400 1.0%, Glyceryl Polyether- 26 1.0%, sorbito...

Embodiment 2

[0058] Oral Care Formulas

[0059] (1) Recombinant human hyaluronic acid composition oropharyngeal repair spray (weight ratio)

[0060] Recombinant Human Hyaluronic Acid 2.5%, Plant Compound 16.0%, Skin Conditioner 2.0%, Glycerin 2.0%, Sorbitol 2.0%, Honey Powder 0.5%, Peppermint 0.1%, Potassium Sorbate 0.5%, Sodium Benzoate 0.2%, add deionized water to 100.

[0061] (2) Recombinant human hyaluronic acid composition nursing toothpaste (weight ratio)

[0062] Recombinant human hyaluronic acid 1.5%, plant compound 8.0%, skin conditioner 1.5%, ascorbic acid 1.0%, sodium lauryl sulfate 2.0%, hydrated silica 18%, sorbitol 30%, xylitol 5.0 %, polyethylene glycol 400 5.0%, chitosan 1.0%, hydroxyethyl cellulose 0.5%, sodium alginate 3.0, mint 1.5%, sodium saccharin 0.2%, add deionized water to 100.

[0063] (3) Tooth brushing tablet of recombinant human hyaluronic acid composition (weight ratio)

[0064] Recombinant human hyaluronic acid 9.0%, plant compound 2.0%, skin conditioner...

Embodiment 3

[0068] hair care formula

[0069] (1) Recombinant human hyaluronic acid composition scalp care solution (weight ratio)

[0070] Recombinant human hyaluronic acid 2.0%, plant compound 3.0%, skin conditioner 5.0%, glycerin 1.5%, F-68 0.05%, finasteride 0.01%, K220 0.1%, add deionized water to 100.

[0071] (2) Recombinant human hyaluronic acid composition shampoo (weight ratio)

[0072] Recombinant human hyaluronic acid 0.5%, plant compound 8.0%, skin conditioner 2.0%, AES (70%) 18%, CAB (30%) 5.0%, 6501 2.0%, pearlescent diester 1.5%, emulsified silicone oil ( 60%) 2.0%, guar gum C-14-S 0.3%, citric acid 0.2%, sodium chloride 0.8%, opening (1.5%) 0.08%, essence 0.5%, EDTA-disodium 0.1%, add Ionized water to 100.

[0073] (3) Recombinant human hyaluronic acid composition hair conditioner (weight ratio)

[0074] Recombinant human hyaluronic acid 0.6%, plant compound 2.0%, skin conditioner 5.0%, aloe extract 20.0%, stearyl alcohol 5.0%, cationic surfactant 8.0%, lanolin 2.0%, ...

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Abstract

The invention provides a recombinant human hyaluronic acid composition which includes, by weight, 0.001-9.0% of recombinant human hyaluronic acid, 0.2-20.0% of a plant compound, 0.05-10.0% of a skin conditioner, and 61.0-99.7% of a matrix auxiliary material. The recombinant human hyaluronic acid is prepared by cutting large-molecular hyaluronic acid by means of saccharified recombinant human hyaluronidase PH20 produced from CHO cells. At least one end of the recombinant human hyaluronic acid has a terminal which is cut by a recombinant human hyaluronidase capable of recognizing the normal structure of hyaluronic acid. A cosmetic prepared from the recombinant human hyaluronic acid composition can promote skin mucosa to secrete functional components; in addition, active components in the cosmetic are quickly diffused and permeate into interior of cells.

Description

technical field [0001] The invention relates to the field of daily chemical industry, in particular to a recombinant human hyaluronic acid composition and its application in cosmetics. Background technique [0002] At present, more and more people begin to use various cosmetics to clean, maintain, beautify, modify and change their appearance on their face, mouth, hair, body and private parts. , The grades are also uneven, which makes it difficult for consumers to choose. With the development of fine chemical technology and the improvement of people's living standards, people are more inclined to daily chemical products with higher safety factor, longer stability and stronger practicability. [0003] Hyaluronic acid, also known as hyaluronic acid, is a high-molecular polymer. It is an advanced acidic mucopolysaccharide composed of units of D-glucuronic acid and N-acetylglucosamine. It is an important basic substance for skin suppleness. It is also a component of the human b...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/9794A61K8/9789A61K8/65A61K8/88A61K8/49A61K8/96A61Q19/00A61Q17/00A61Q19/08A61Q19/02A61Q11/00A61Q5/12A61P1/02A61P17/10A61P7/04A61P31/02A61P15/02
CPCA61K8/735A61K8/4946A61K8/65A61K8/73A61K8/88A61K8/965A61K8/97A61Q5/008A61Q5/12A61Q11/00A61Q17/005A61Q19/00A61Q19/008A61Q19/02A61Q19/08
Inventor 贺晓军侯如标叶轶李秋艳
Owner 海盾医美科技(杭州)有限公司
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