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Preparation method of instantly dissolved azithromycin oral suspension

A technology for oral suspension and azithromycin, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve problems such as poor dosage and taste, and achieve good preparation stability Prospects for clinical application, overcoming the effect of subdivided dose and poor taste

Active Publication Date: 2017-12-22
杭州市西溪医院
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Problems solved by technology

[0003] The purpose of the present invention is to overcome the deficiencies of the above-mentioned background technology and provide a preparation method of instant azithromycin oral suspension. The preparation process of the method is simple, and the obtained instant azithromycin suspension has both dry suspension and The quality is stable, and it overcomes the shortcomings that it cannot be further accurately subdivided into doses and poor taste, and has excellent clinical application prospects.

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  • Preparation method of instantly dissolved azithromycin oral suspension
  • Preparation method of instantly dissolved azithromycin oral suspension

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Embodiment Construction

[0023] Further description will be given below through specific examples.

[0024] The present invention successfully prepares an instant azithromycin oral suspension through prescription screening, process optimization and long-term and short-term preparation stability tests.

[0025] One, the preparation method of instant azithromycin oral suspension

[0026] 1) Preparation of azithromycin suspension powder

[0027] Weigh 60g of oral azithromycin raw material, 175g of diluent, and 15g of sodium bicarbonate, mix them in equal increments, and sub-package them into 2.5g / packages, each containing 600mg of oral azithromycin raw material.

[0028] 1) The diluent involved in the above can be water-soluble auxiliary materials such as glucose, sucrose, lactose, xylitol, mannitol, etc. as required, and can be one of them, or a mixture of several in any proportion. The purpose of adding it is to dilute the azithromycin so that it can be easily subpackaged and uniformly dispersed in t...

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Abstract

The invention relates to a preparation method of antibiotics, and aims to provide a preparation method of an instantly dissolved azithromycin oral suspension. The method is simple in preparation process, the obtained instantly dissolved azithromycin oral suspension also has the characteristic of stable quality of a dry suspension, the shortcomings that dosage cannot be further subdivided accurately and the taste is poor are overcome, and the clinical application prospect is good. According to the technical scheme, the preparation method of the instantly dissolved azithromycin oral suspension comprises the following steps: (1) preparing powder for suspending of azithromycin, weighing 600 mg of azithromycin oral crude drugs, 1,750 mg of a diluent and 150 mg of sodium bicarbonate, and then uniformly mixing and packing; (2) preparation of a blank solution for suspending: (a) weighing blank solution raw materials for suspending; and (b) preparing the blank solution by a corresponding preparation process.

Description

technical field [0001] The invention relates to a preparation method of an antibiotic preparation, in particular to a preparation method of an instant azithromycin oral suspension. Background technique [0002] Azithromycin is a broad-spectrum antibiotic obtained by modifying the chemical structure of erythromycin. It was originally developed by Yugoslav SourPliva Company. It has broad antibacterial spectrum, stable acid, good absorption, high bioavailability, long half-life, low toxicity and resistance. Good acceptance and so on. It is suitable for all kinds of people, especially children and the elderly. Domestic and foreign literature reports involve oral dry suspensions, microsphere dry suspensions, vesicles, gels, taste-masking enteric-coated sustained-release microspheres, etc. Common pediatric preparations on the domestic market include dry suspensions and Granules, without azithromycin oral suspension. However, in the clinical and working practice of pediatrics, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/7052A61K47/02A61K47/12A61P31/04
CPCA61K9/0053A61K9/10A61K31/7052A61K47/02A61K47/12
Inventor 李松龙茹仁萍
Owner 杭州市西溪医院
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