The invention discloses a multi-index fusion-based driver fatigue detection method. The method comprises the steps of firstly, acquiring a face image of a driver in a normal state to carry out human face positioning, selecting a first face feature point, and determining a driver eye fatigue judgment threshold value through the first face feature point; acquiring a face image of the driver in a driving state, carrying out human face positioning, selecting a second face feature point, and calculating an eye fatigue index, a mouth fatigue index and a head posture fatigue index of the driver; andin combination with the eye fatigue index, the mouth fatigue index and the head posture fatigue index, judging whether the driver is in fatigue driving or not. According to the method, various physiological characteristics of a person in a fatigue state are comprehensively considered, and the fatigue state of the driver is detected in a multi-index fusion mode, so that the fatigue state of the driver can be detected more accurately, and the problems of easy disturbance and low identification accuracy of a traditional single-index detection method are effectively solved.