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Diphenyl ether compound with antibacterial activity in honeysuckle and preparation method and application thereof

A technology of antimicrobial activity, diphenyl ethers, applied in the field of natural product chemistry

Active Publication Date: 2018-01-05
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This compound has not been reported so far

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  • Diphenyl ether compound with antibacterial activity in honeysuckle and preparation method and application thereof
  • Diphenyl ether compound with antibacterial activity in honeysuckle and preparation method and application thereof
  • Diphenyl ether compound with antibacterial activity in honeysuckle and preparation method and application thereof

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Effect test

Embodiment 1

[0046] The honeysuckle sample comes from Kunming, Yunnan, and the variety is Honeysuckle Tree No. 3.

[0047] A preparation method of diphenyl ether compounds with antibacterial activity in honeysuckle, comprising the following steps:

[0048] Step (1), extraction of extract: use dried honeysuckle as raw material, crush honeysuckle to 30-50 mesh, use 80% by weight methanol aqueous solution as extraction solvent, soak and extract 3 times, soak for 24 hours each time, The weight ratio of second used extraction solvent and Flos Lonicerae Flos Lonicerae is 3:1, merges extract, filters, and filtrate is concentrated into extractum;

[0049] Step (2), silica gel column chromatography: the extract is first dissolved in methanol with 1.5 times the weight of the extract, then mixed with 80-100 mesh silica gel with 0.8 times the weight of the extract, and then loaded for column chromatography. , the column silica gel is 160 mesh, the method of silica gel column packing is dry packing, a...

Embodiment 2

[0054] The honeysuckle sample comes from Kunming, Yunnan, and the variety is Honeysuckle Tree No. 3.

[0055] A preparation method of diphenyl ether compounds with antibacterial activity in honeysuckle, comprising the following steps:

[0056] Step (1), extraction of extract: use dried honeysuckle as raw material, crush honeysuckle to 30-50 mesh, use methanol as extraction solvent, soak and extract 5 times, soak for 72 hours each time, the weight of the extraction solvent and honeysuckle used each time The ratio is 5:1, the combined extracts are filtered, and the filtrate is concentrated into an extract;

[0057] Step (2), silica gel column chromatography: first dissolve the extract with acetone 3 times the weight of the extract, then mix the sample with 100-mesh silica gel 1.2 times the weight of the extract, and then load the sample for column chromatography. The column silica gel is 300 mesh, and the method of silica gel column packing is dry packing, and the weight of sil...

Embodiment 3

[0062]The honeysuckle sample comes from Kunming, Yunnan, and the variety is Honeysuckle Tree No. 3.

[0063] A preparation method of diphenyl ether compounds with antibacterial activity in honeysuckle, comprising the following steps:

[0064] Step (1), extraction of extract: use dried honeysuckle as raw material, crush honeysuckle to 30-50 mesh, use 80% ethanol aqueous solution as extraction solvent, soak and extract 4 times, soak for 36 hours each time, The weight ratio of each used extraction solvent and Flos Lonicerae Flos Lonicerae is 4:1, merges extract, filters, and filtrate is concentrated into medicinal extract;

[0065] Step (2), silica gel column chromatography: first dissolve the extract with acetone twice the weight of the extract, then mix the sample with 90-mesh silica gel that is twice the weight of the extract, and then load the sample for column chromatography. The column silica gel is 200 mesh, and the method of silica gel column packing is dry method packin...

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Abstract

The invention relates to a diphenyl ether compound with antibacterial activity in honeysuckle and its preparation method and application, belonging to the technical field of natural product chemistry. The structural formula of the compound is shown in formula (I):, formula (I); the compound is prepared from the traditional medicinal and edible homologous plant honeysuckle as raw material, and is obtained through extraction of extract, silica gel column chromatography and high pressure liquid chromatography separation and purification steps . The activity test shows that the compound of the present invention has good antibacterial effect, adding the compound of the present invention to the tobacco feed liquid can effectively inhibit the growth of microorganisms in the feed liquid, prolong the shelf life of the tobacco feed liquid, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and specifically relates to a diphenyl ether compound extracted for the first time from the traditional medicine and food homology plant honeysuckle. At the same time, the invention also relates to a preparation method of the compound and its application in preventing corruption and deterioration of tobacco material liquid and prolonging the shelf life of tobacco tobacco material liquid. Background technique [0002] Honeysuckle, also known as honeysuckle, is a perennial semi-evergreen woody medicinal and edible plant of the family Lonicera. Because it is white at first and then turns yellow, it is named honeysuckle. Honeysuckle is a kind of honeysuckle that has been praised as a good medicine for clearing away heat and detoxification since ancient times. It is sweet and cold in nature and fragrant. Honeysuckle can not only disperse wind-heat, but also clear blood toxin. It is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/84C07C45/78A01N35/04A01P3/00A01P1/00A24B15/34
Inventor 张承明孔维松刘欣李晶耿永勤李雪梅米其利刘志华王明峰者为周敏杨光宇胡秋芬李干鹏
Owner CHINA TOBACCO YUNNAN IND
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