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Composite macroporous resin purifying method for radix salviae miltiorrhizae extract

A technology of macroporous resin and purification method, which is applied to the purification of extracts and the field of compound macroporous resin purification of Salvia miltiorrhiza extract, which can solve the problem of high content of active ingredients and achieve the effect of improving the content and quality of active ingredients

Inactive Publication Date: 2018-01-09
廖凌峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems existing in the purification of the salvia miltiorrhiza extract in the prior art, and provides a compound macroporous resin purification method for the salvia miltiorrhiza extract, which effectively separates the strong water-soluble part in the active ingredients of the salvia miltiorrhiza extract Purification, and the resulting product has a high content of active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A compound macroporous resin purification method of salvia miltiorrhiza extract includes the following process steps:

[0017] A. Put the salvia miltiorrhiza in a heating container, add distilled water; soak for 1 hour; raise the system temperature to 90°C and keep it for 4 hours; repeat the above extraction process 3 times; collect all 3 extracts, filter, and set aside;

[0018] B. Pass the filtrate through the strong polar macroporous resin chromatography column from top to bottom at a speed of 100ml / h; after the passage, use deionized water to wash off the remaining extract in the chromatography column;

[0019] C. Use 75-80% alcohol to elute the effective components adsorbed on the resin column at a flow rate of 50ml / h; the effluent alcohol eluent flows through the decolorizing resin chromatography column to decolorize the eluent;

[0020] D. Collect the decolorized alcohol eluate; concentrate and recover the alcohol; dry the concentrate under vacuum conditions to obtain a p...

Embodiment 2

[0022] A compound macroporous resin purification method of salvia miltiorrhiza extract includes the following process steps:

[0023] A. Put the salvia miltiorrhiza in a heating container, add distilled water; soak for 3 hours; raise the temperature of the system to 100°C and keep it for 6 hours; repeat the above extraction process 3 times; collect all 3 extracts, filter, and set aside;

[0024] B. Pass the filtrate through the strong polar macroporous resin chromatography column from top to bottom at a speed of 120ml / h; after passing through, use deionized water to wash off the remaining extract in the chromatography column;

[0025] C. Use 75-80% alcohol to elute the effective components adsorbed on the resin column at a flow rate of 60ml / h; the effluent alcohol eluent flows through the decolorizing resin chromatography column to decolorize the eluent;

[0026] D. Collect the decolorized alcohol eluate; concentrate and recover the alcohol; dry the concentrate under vacuum conditions ...

Embodiment 3

[0028] A compound macroporous resin purification method of salvia miltiorrhiza extract includes the following process steps:

[0029] A. Put the salvia miltiorrhiza in a heating container, add distilled water; soak for 2h; increase the temperature of the system to 95°C and keep it for 5h; repeat the above extraction process 3 times; collect all 3 extracts, filter, and set aside;

[0030] B. Pass the filtrate through the strong polar macroporous resin chromatography column from top to bottom at a speed of 110ml / h; after the passage, use deionized water to wash off the remaining extract in the chromatography column;

[0031] C. Use 75-80% alcohol to elute the effective components adsorbed on the resin column at a flow rate of 55ml / h; the effluent alcohol eluent flows through the decolorizing resin chromatography column to decolorize the eluent;

[0032] D. Collect the decolorized alcohol eluate; concentrate and recover the alcohol; dry the concentrate under vacuum conditions to obtain a ...

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Abstract

The invention relates to a compound macroporous resin purification method of salvia miltiorrhiza extract, belonging to the technical field of macroporous resins. The invention adopts a strong polar macroporous adsorption resin and a decolorizing resin to effectively separate and purify the strong water-soluble components in the active ingredients of natural products and traditional Chinese medicines, and the obtained product has a higher content of active ingredients. The invention adopts a highly polar macroporous resin with strong polarity, which effectively solves the difficult problem of separation and purification of highly water-soluble effective components in the salvia miltiorrhiza extract. At the same time, the present invention also adds a decolorization process in the later stage of separation and purification, so that the content and quality of active ingredients in the salvia miltiorrhiza extract are significantly improved.

Description

Technical field [0001] The invention relates to a method for purifying an extract, more specifically, the invention relates to a method for purifying a salvia miltiorrhiza extract with a composite macroporous resin, which belongs to the technical field of macroporous resin. Background technique [0002] The active ingredients contained in the water extract of Salvia miltiorrhiza have strong polarity and high water solubility, which makes it difficult to separate and purify them through traditional processes. If the process of boil-drying is used for concentration, it will inevitably cause excessive energy consumption, and the resulting product has a low content of effective ingredients, making it difficult to prepare drugs with high efficacy. However, the generally used non-polar macroporous resin is difficult to effectively adsorb it to achieve the purpose of separation and purification. [0003] Therefore, the separation and purification of active ingredients of traditional Chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02B01D15/10B01D15/42A61K36/537
Inventor 廖凌峰
Owner 廖凌峰
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