Gold nanoclusters as well as preparation method and application thereof
A technology of gold nanoclusters and mercapto groups, which is applied in the field of gold clusters and can solve the problems of non-adjustable luminescent wavelength and limiting the application of gold nanoclusters
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[0017] The invention provides a method for preparing gold nanoclusters, comprising mixing mercaptocyclodextrin solution, glutathione solution, water and gold source compound solution, and mixing them in sodium hydroxide solution and / or potassium hydroxide solution In the case of heating reaction step.
[0018] Through the above technical scheme, the present invention reacts the ligand mercapto-cyclodextrin and the ligand glutathione (GSH) with the gold source compound, and the -SH group and Au in the mercapto-cyclodextrin and glutathione Au-S covalent bonds are formed to obtain gold nanoclusters modified by the two ligands, and gold nanoclusters with different emission wavelengths can be obtained by changing the ratio of modifiers. In this way, the two surface recognition groups of mercapto-cyclodextrin and glutathione (GSH) can be combined with the luminescent properties of gold nanoclusters, which can be used for bioimaging. Not only that, the present invention combines two ...
Embodiment 1
[0041] Take 400μL 100mmol / L mercapto-β-cyclodextrin solution and 100μL 100mmol / L glutathione solution and mix evenly, add 8.5mL water, then add 1mL 20mmol / L chloroauric acid solution, stir for 30min, the solution is White and cloudy. 100 μL of 1mol / L NaOH solution was added dropwise to the solution to adjust the pH to 8. At this time, the solution turned into a colorless and clear state, and heated to reflux at 70°C for 24 hours to obtain gold nanoclusters AuNCs-1.
[0042] Take the above-mentioned synthesized gold-containing nanocluster AuNCs-1 mixed solution and absolute ethanol in a ratio of 1:1, centrifuge at 8000rpm / min for 20min in a centrifuge, take out the supernatant with a pipette gun, and disperse the lower precipitate with water , repeat the above centrifugation operation, disperse the lower precipitate with water and put it in the refrigerator for later use.
Embodiment 2
[0044] Gold nanocluster AuNCs-2 was prepared according to the method of Example 1, except that the concentration of mercapto-β-cyclodextrin solution was 25 mmol / L, and the concentration of glutathione solution was 400 mmol / L.
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