Gold nanoclusters as well as preparation method and application thereof

A technology of gold nanoclusters and mercapto groups, which is applied in the field of gold clusters and can solve the problems of non-adjustable luminescent wavelength and limiting the application of gold nanoclusters

Active Publication Date: 2018-01-09
天津市源创环保设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the gold nanoclusters obtained by the above synthesis method have only one ligand on the surface and the emission wavelength cannot be adjusted.
However, there are relatively few reports on gold nanoclusters with two modifiers on the surface and tunable luminescence, which limits the application of gold nanoclusters.

Method used

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  • Gold nanoclusters as well as preparation method and application thereof
  • Gold nanoclusters as well as preparation method and application thereof
  • Gold nanoclusters as well as preparation method and application thereof

Examples

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preparation example Construction

[0017] The invention provides a method for preparing gold nanoclusters, comprising mixing mercaptocyclodextrin solution, glutathione solution, water and gold source compound solution, and mixing them in sodium hydroxide solution and / or potassium hydroxide solution In the case of heating reaction step.

[0018] Through the above technical scheme, the present invention reacts the ligand mercapto-cyclodextrin and the ligand glutathione (GSH) with the gold source compound, and the -SH group and Au in the mercapto-cyclodextrin and glutathione Au-S covalent bonds are formed to obtain gold nanoclusters modified by the two ligands, and gold nanoclusters with different emission wavelengths can be obtained by changing the ratio of modifiers. In this way, the two surface recognition groups of mercapto-cyclodextrin and glutathione (GSH) can be combined with the luminescent properties of gold nanoclusters, which can be used for bioimaging. Not only that, the present invention combines two ...

Embodiment 1

[0041] Take 400μL 100mmol / L mercapto-β-cyclodextrin solution and 100μL 100mmol / L glutathione solution and mix evenly, add 8.5mL water, then add 1mL 20mmol / L chloroauric acid solution, stir for 30min, the solution is White and cloudy. 100 μL of 1mol / L NaOH solution was added dropwise to the solution to adjust the pH to 8. At this time, the solution turned into a colorless and clear state, and heated to reflux at 70°C for 24 hours to obtain gold nanoclusters AuNCs-1.

[0042] Take the above-mentioned synthesized gold-containing nanocluster AuNCs-1 mixed solution and absolute ethanol in a ratio of 1:1, centrifuge at 8000rpm / min for 20min in a centrifuge, take out the supernatant with a pipette gun, and disperse the lower precipitate with water , repeat the above centrifugation operation, disperse the lower precipitate with water and put it in the refrigerator for later use.

Embodiment 2

[0044] Gold nanocluster AuNCs-2 was prepared according to the method of Example 1, except that the concentration of mercapto-β-cyclodextrin solution was 25 mmol / L, and the concentration of glutathione solution was 400 mmol / L.

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Abstract

The invention discloses gold nanoclusters as well as a preparation method and an application thereof. The preparation method of the gold nanoclusters comprises steps as follows: a mercapto-cyclodextrin solution, a GSH (glutathione) solution, water and a gold-sourced compound solution are mixed and subjected to a heating reaction under the condition that a sodium hydroxide solution and/or a potassium hydroxide solution exist. The mercapto-cyclodextrin and GSH as ligands react with the gold-sourced compound solution, the gold nanoclusters modified with two ligands are obtained and are used for bio-imaging, two ligands are combined, the gold nanoclusters with different particle sizes can be prepared through adjusting of the adding quantities of the two ligands during synthesis, meanwhile, theprepared gold nanoclusters can emit light with different wavelengths, the sizes and light-emitting wavelength of the gold nanoclusters can be simply and feasibly adjusted, and accordingly, the application of the gold nanoclusters is further extended.

Description

technical field [0001] The present invention relates to gold clusters, in particular to gold nanoclusters and their preparation methods and applications. Background technique [0002] Gold nanoclusters (AuNCs) are generally molecular-level aggregates composed of several to tens of atoms, in which some small organic molecules such as thiol compounds or proteins such as bovine serum albumin are used as protective groups. In clusters, due to the steric confinement of its free electrons, resulting in discrete, tunable electronic transitions, it exhibits some unique physicochemical properties, especially its fluorescence. The size of gold nanoclusters is very small (≤2nm), which is equivalent to the Fermi wavelength of electrons. Due to the quantum confinement effect, it will produce properties similar to semiconductors-energy level separation, so it will produce fluorescence when excited. Gold nanoclusters have many advantages: the synthesis conditions of gold nanoclusters are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06G01N21/64
Inventor 夏云生刘春秀朱慧朱霜霜吕杨凌云云汪宜张冰洁马明柔韦妹妹罗荣
Owner 天津市源创环保设备有限公司
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