Application of tachyplesin peptides in preparation of medicine and healthcare products for preventing and treating pulmonary fibrosis

A technology for pulmonary fibrosis and health care products, applied in the field of medicine, can solve the problem of pulmonary fibrosis without limulus peptide, and achieve the effect of inhibiting the formation of pulmonary fibrosis

Active Publication Date: 2018-01-30
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various research data show that the limulus peptide has a strong antibacterial effect, inhibits the growth of gram-negative bacteria, gram-positive bacteria, and fungi, and also finds that the limulus peptide has an anti-tumor effect, but so far there is no limulus peptide on the lungs. Related reports on the role of fibrosis

Method used

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  • Application of tachyplesin peptides in preparation of medicine and healthcare products for preventing and treating pulmonary fibrosis
  • Application of tachyplesin peptides in preparation of medicine and healthcare products for preventing and treating pulmonary fibrosis
  • Application of tachyplesin peptides in preparation of medicine and healthcare products for preventing and treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The oral liquid is prepared by making the limulus peptide and the glucose solution, wherein the concentration of the limulus peptide is 1-10 mg / kg, and it is taken orally once a day.

Embodiment 2

[0033] The injection injection is made of the limulus peptide and physiological saline, wherein the concentration of the limulus peptide is 1-10 mg / kg, and injected once a day.

Embodiment 3

[0035] The limulus peptide is used in combination with the glucocorticoid, and after the glucocorticoid is taken, the limulus peptide oral liquid with a concentration of 1-10 mg / kg is orally administered.

[0036] Evaluation

[0037] 1. Evaluation method

[0038] Animals and Grouping SPF grade KM mice, 22g±2g, 60, female. Mice were divided into control group, model group, glucocorticoid group (5mg / kg) and low (1mg / kg) middle (5mg / kg) and high (10mg / kg) dose groups of limulusin peptide by random number table method. Group 10. After the mice were anesthetized by intraperitoneal injection of 1% pentobarbital sodium at a dose of 50 mg / Kg, they were fixed on the operating table in a supine position, the tongue was pulled out with tweezers to expose the trachea, and 5 mg / kg bleomycin was slowly injected under a cold light source magnifying glass. After the injection, the mouse board was erected quickly and rotated for 3 minutes to distribute the liquid medicine evenly in the lung...

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Abstract

The invention discloses new application of tachyplesin peptides. The tachyplesin peptides can be used for preparing medicine and healthcare products for preventing and treating pulmonary fibrosis, used as the effective component of the medicine and healthcare products for preventing and treating pulmonary fibrosis, used for the prodrug modification of the medicine for preventing and treating pulmonary fibrosis or used along with the preventing and treating pulmonary fibrosis to treat the pulmonary fibrosis. The tachyplesin peptides are prepared by waste materials of horseshoe crab blood cell or horseshoe crab reagent production and can evidently inhibit the formation of the pulmonary fibrosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a limulus peptide in the preparation of medicines for preventing and treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a common complication of the respiratory system, which poses a great threat to human health. Based on the "Evidence-Based Guidelines for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis" jointly developed by the American Thoracic Society (ATS), the European Respiratory Society (ERS), the Japanese Respiratory Society (JRS) and the Latin American Thoracic Society (ALAT), it is pointed out that some drugs It has a potential effect on PF patients. For patients with a strong desire to use drugs, they can choose from the following four prevention and treatment options: ①N-acetylcysteine, azathioprine, and prednisone; ②N-acetylcysteine ​​single-drug prevention and treatment; ③ Anticoagulant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61P11/00A23L33/18
Inventor 张海涛余华军伍俊
Owner GUANGDONG MEDICAL UNIV
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