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A kind of preparation method containing mercaptophosphorylcholine polymer

A technology of mercaptophosphorylcholine and phosphorylcholine, which is applied in the preparation of polymers containing mercaptophosphorylcholine and in the field of improving the biocompatibility of materials, can solve problems such as shedding, easy dissolution, and degradation, and meet the conditions Mild, simple preparation method, and broad application prospects

Inactive Publication Date: 2020-10-16
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to solve the problems that the phosphorylcholine polymer coating physically coated on the surface of the material by the above-mentioned existing phosphorylcholine polymer is prone to dissolve, degrade, or even fall off in a complex physiological environment. Provide a kind of preparation method containing mercaptophosphorylcholine polymer

Method used

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  • A kind of preparation method containing mercaptophosphorylcholine polymer
  • A kind of preparation method containing mercaptophosphorylcholine polymer
  • A kind of preparation method containing mercaptophosphorylcholine polymer

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preparation example Construction

[0023] A kind of preparation method of the present invention contains mercaptophosphorylcholine polymer, the vinyl monomer containing phosphorylcholine group is methacryloyloxyethylphosphorylcholine, such as figure 1 As shown, the specific steps are as follows:

[0024] Step 1. Under the protection of nitrogen, the vinyl monomer containing phosphorylcholine group and the styrene monomer are subjected to free radical polymerization under the action of an initiator to obtain a phosphorylcholine polymer containing a benzene ring; Free radical polymerization reaction: The polymerization temperature is 70°C, the solvent used is a mixed solvent of methanol and tetrahydrofuran (volume ratio is 4:1), the polymerization time is 12 to 24 hours, vinyl monomers containing phosphorylcholine groups and styrene The monomer molar ratio is about 60:40~30:70.

[0025] Step 2, mix the phosphorylcholine polymer containing benzene ring described in step 1 with zinc chloride and chloromethyl ether...

Embodiment 1

[0029] Weigh 10mmol of 2-methacryloyloxyethylphosphorylcholine and 10mmol of styrene, dissolve and mix them uniformly in a mixed solvent of methanol and tetrahydrofuran (volume ratio: 4:1) to obtain a mixed solution of monomers. in N 2 Protection, under the condition of stirring at 70°C, add 0.1mmol of azobisisobutyronitrile into the three-neck flask to add the mixed solution of monomers, after preheating for 30min, add the initiator solution to continue the reaction for 20h, after the reaction is completed, concentrate the reaction solution , dialyzed with a dialysis bag with a molecular weight cut-off of 6000-8000D, and then freeze-dried at -50°C to obtain a phosphorylcholine polymer containing a benzene ring.

[0030] Weigh 0.2g of the phosphorylcholine polymer containing benzene ring prepared in this example and dissolve it with 30mL of chloroform and methanol mixed solvent (volume ratio is 1:1), then add 0.2g of zinc chloride and 5mL of chloromethyl ether to mix Evenly, ...

Embodiment 2

[0034] Weigh 12mmol of 2-methacryloyloxyethylphosphorylcholine and 8mmol of styrene, dissolve and mix them uniformly in a mixed solvent of methanol and tetrahydrofuran (volume ratio: 4:1) to obtain a mixed solution of monomers. in N 2 Protection, under the condition of stirring at 60°C, add 0.1mmol of azobisisobutyronitrile to the three-necked flask, add the mixed solution of monomers, after preheating for 30min, add the initiator solution to continue the reaction for 24h, after the reaction is completed, concentrate the reaction solution , dialyzed with a dialysis bag with a molecular weight cut-off of 6000-8000D, and then freeze-dried at -50°C to obtain a phosphorylcholine polymer containing a benzene ring.

[0035] Weigh 0.2g of the phosphorylcholine polymer containing benzene ring prepared in this example and dissolve it with 30mL of chloroform and methanol mixed solvent (volume ratio is 1:1), then add 0.2g of zinc chloride and 5mL of chloromethyl ether to mix Evenly, rea...

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Abstract

The invention discloses a preparation method of a mercapto-containing phosphorylcholine polymer. The preparation method includes: subjecting a vinyl monomer containing phosphorylcholine hydrophilic group and styrene to simple solution radical polymerization to synthesize a phosphorylcholine polymer containing benzene ring, and carrying out chloromethylation reaction on the phosphorylcholine polymer containing benzene ring, zinc chloride and chloromethyl ether at certain temperature, then using sodium hydrosulfide to carry out nucleophilic substitution reaction under certain condition, thus obtaining the mercapto-containing phosphorylcholine polymer. The preparation method is simple and has mild conditions, and provides a new approach for the mercapto-containing phosphorylcholine polymer. The mercapto-containing phosphorylcholine polymer imitating the cell outer membrane structure can have broad application prospects in in-vivo implantation materials, tissue engineering, drug sustainedrelease, biosensors and other fields.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and specifically relates to a preparation method of a polymer containing mercaptophosphorylcholine and a method for improving the biocompatibility of materials. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/36C08F212/08C08F8/34C08F8/24A61L27/16A61L27/50
CPCA61L27/16A61L27/50C08F8/34C08F212/08C08F220/36C08F8/24C08L43/02C08L25/14
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH