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A medicinal composition for treating hypertensive nephropathy and preparation method thereof

A technology of hypertensive nephropathy and composition, which is applied in the field of pharmaceutical composition for the treatment of hypertensive nephropathy, and can solve problems such as difficult cure

Active Publication Date: 2020-10-09
呼伦贝尔恒扬民间医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no clinical manifestation of kidney damage in the early stage of hypertensive nephropathy, so it has not attracted great attention. Once clinical manifestations or abnormalities are found in routine tests, the kidney disease has reached a very serious level, and it is very difficult to cure

Method used

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  • A medicinal composition for treating hypertensive nephropathy and preparation method thereof
  • A medicinal composition for treating hypertensive nephropathy and preparation method thereof
  • A medicinal composition for treating hypertensive nephropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] The preparation method is as follows:

[0021] Crush Aconitum and Myrobalan into coarse powder, then soak in fresh milk, take it out after 8 hours, and drain; mix the milked Aconitum and Myrobalan with the remaining nine flavors, add 50% ethanol (weight concentration) Reflux extraction for 3 hours, filter, recover ethanol from the filtrate until there is no alcohol smell, and set aside; add water to the filter residue and decoct for extraction twice, each time for 2 hours, filter, combine the filtrate with the above ethanol extract, and concentrate to a thick paste with a relative density of 1.35 (65.5Kg), the thick paste is mixed with 600Kg of sucrose powder and made into granules.

[0022] Specifications: 20g per bag (equivalent to 5.8g raw medicinal materials)

[0023] Instructions: Take after boiling water, once in the morning and evening, 1 bag each time.

Embodiment 2

[0025]

[0026] The preparation method is as follows:

[0027] Crush Aconitum and Myrobalan into coarse powder, then soak in fresh milk, take it out after 5 hours, and drain; mix the milked Aconitum and Myrobalan with the remaining nine flavors, add water and boil 3 times, each time After 1 hour, filter, combine the filtrate and concentrate into a thick paste with a relative density of 1.4, mix the thick paste with sucrose powder and make granules, and press into tablets to make tablets.

Embodiment 3

[0029]

[0030] The preparation method is as follows:

[0031] Crush Aconitum and Myrobalan into coarse powder, then soak in fresh milk, take it out after 5 hours, and drain; mix the milked Aconitum and Myrobalan with the remaining nine flavors, grind them into fine powder, add honey to make Form into pills.

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Abstract

The invention discloses a medicinal composition for treating hypertensive nephropathy. The medicinal composition is composed of the following ingredients: fructus chebulae, fructus gardeniae, fructustoosendan, flos carthami, folium eriobotryae, lacca, radix aconiti kusnezoffii, resin commiphorae muakulis(guggulum), fructus amomi rotundus, white soybeans, all-grass of oxytropis myriophylla, and the like. The medicinal composition provided by the invention can obviously reduce urine protein and urine microalbumin, and has the total effective rate achieving 90% when used for treating proteinuria, after 24h of treatment for urine protein, urine microalbumin, serum creatinine, urea nitrogen, blood and urine beta2-MG, the result shows that the medicinal composition has the obvious efficiency intreating hypertensive nephropathy, and can obviously improve proteinuria, and protect the kidney function.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a pharmaceutical composition for treating hypertensive nephropathy. Background technique [0002] Hypertension is a cardiovascular disease. In addition to the obvious symptoms caused by elevated blood pressure, high blood pressure can also cause systemic damage. Some important organs such as the heart, kidneys, brain, and eyes may appear abnormal. As the main component of the kidney is the glomerulus, which contains many capillaries and is very sensitive to changes in blood pressure, so the increase in blood pressure in patients with hypertension will directly affect the glomerulus, causing kidney disease, which is hypertension kidney disease. At the same time, kidney damage will also aggravate hypertension, and the two can easily form a vicious circle. [0003] In the early stage of hypertensive nephropathy, the function of urine concentration is decreased, the patients have increased ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P13/12A61P9/12
CPCA61K36/185A61K36/286A61K36/30A61K36/328A61K36/48A61K36/58A61K36/714A61K36/73A61K36/744A61K36/9064A61K2300/00
Inventor 黄晓华
Owner 呼伦贝尔恒扬民间医药研究院
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