Indoleamine 2, 3-dioxygenase inhibitor containing tanshinone compound
A dioxygenase and compound technology, applied in steroids, medical preparations containing active ingredients, organic chemistry, etc., can solve the differences in physical properties, chemical properties and biological activities, and the structure-activity relationship needs further research and influence Physical properties, chemical properties and biological activities
Inactive Publication Date: 2018-02-16
SUN YAT SEN UNIV
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[0006] However, since some groups in a compound will significantly affect its physical properties, chemical properties and biological activities, even compounds with similar skeletons may have huge differences in their physical properties, chemical properties and biological activities
Experiments have shown that
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[0022] In order to fully understand the technical content of the present invention, the technical solutions of the present invention will be further introduced and illustrated below in conjunction with specific embodiments.
[0023] The inhibitory activities of tanshinone compounds J1-J13 and compounds K1-K7 on indoleamine 2,3-dioxygenase were tested and evaluated respectively. The structures of compounds K1-K7 are shown below, respectively.
[0024]
[0025]
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The invention relates to the technical field of indoleamine 2, 3-dioxygenase inhibitors, in particular to an indoleamine 2, 3-dioxygenase inhibitor with a tanshinone compound as the active substance.IDO inhibitory activity detection shows that the tanshinone compound of the structure or pharmaceutically acceptable salts thereof can have an inhibitory effect on IDO, and can obstruct and/or damagethe promotion effect of IDO in occurrence and development of diseases, thus providing good prospects for treatment of IDO mediated tryptophan metabolic pathway pathological feature diseases.
Description
technical field [0001] The invention relates to the technical field of indoleamine 2,3-dioxygenase inhibitors, in particular to an indoleamine 2,3-dioxygenase inhibitor with tanshinone compounds as active substances. Background technique [0002] Indoleamine 2,3-dioxygenase (IDO) is a dimeric enzyme containing heme in cells, which is the key to controlling the metabolism of tryptophan along the kynurenine pathway rate-limiting steps. It is expressed in a variety of tissues and cells, including placenta, lung, large intestine, small intestine, colon, spleen, liver, kidney, stomach, brain, tumor cells, dendritic cells, and macrophages. [0003] IDO is closely related to many diseases, and the expression of IDO is up-regulated in infectious diseases, cancer, nerve-related diseases, cataract and other diseases. In infectious diseases and cancer, when there is an inflammatory response, some biological factors, such as IFN-γ and NF-κB, will induce the high expression of IDO gene...
Claims
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Login to view more IPC IPC(8): C07J73/00A61K31/58A61P35/00A61P25/28A61P25/16A61P25/24A61P25/14A61P31/00A61P27/12A61P35/02A61P31/04A61P31/10A61P33/00
CPCC07J73/003
Inventor 顾琼张宏奥徐峻周晖皓
Owner SUN YAT SEN UNIV
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