Indoleamine 2, 3-dioxygenase inhibitor containing tanshinone compound

Abstract

The invention relates to the technical field of indoleamine 2, 3-dioxygenase inhibitors, in particular to an indoleamine 2, 3-dioxygenase inhibitor with a tanshinone compound as the active substance.IDO inhibitory activity detection shows that the tanshinone compound of the structure or pharmaceutically acceptable salts thereof can have an inhibitory effect on IDO, and can obstruct and / or damagethe promotion effect of IDO in occurrence and development of diseases, thus providing good prospects for treatment of IDO mediated tryptophan metabolic pathway pathological feature diseases.

Description

technical field [0001] The invention relates to the technical field of indoleamine 2,3-dioxygenase inhibitors, in particular to an indoleamine 2,3-dioxygenase inhibitor with tanshinone compounds as active substances. Background technique [0002] Indoleamine 2,3-dioxygenase (IDO) is a dimeric enzyme containing heme in cells, which is the key to controlling the metabolism of tryptophan along the kynurenine pathway rate-limiting steps. It is expressed in a variety of tissues and cells, including placenta, lung, large intestine, small intestine, colon, spleen, liver, kidney, stomach, brain, tumor cells, dendritic cells, and macrophages. [0003] IDO is closely related to many diseases, and the expression of IDO is up-regulated in infectious diseases, cancer, nerve-related diseases, cataract and other diseases. In infectious diseases and cancer, when there is an inflammatory response, some biological factors, such as IFN-γ and NF-κB, will induce the high expression of IDO gene...

AI Technical Summary

Problems solved by technology

[0006] However, since some groups in a compound will significantly affect its physical properties, chemical properties and biological activities, even compounds with similar skeletons may have huge differences in their physical properties, chemical properties and biological activities

Experiments have shown that different substituents or double bonds on the six-membered ring and five-membered ring containing 6, 7, 8, and 9 carbon positions of tanshinone compounds have a significant impact on the activity of inhibiting indoleamine 2,3-dioxygenase , the specific structure-activity relationship needs to be further studied

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