A kind of serum IFN-γ and lncRNAs composition is used for the purpose of preparing gastric cancer diagnostic kit

Abstract

The invention discloses a use of a serum IFN-gamma and LncRNAs composition in preparation of a gastric cancer diagnostic kit. The area (AUC) under the ROC curve is 0.636 in the diagnosis and distinguishing of gastric cancer and healthy volunteers using serum IFN-gamma alone. The present invention finds that when using the combination of serum NONHSAT089447 or NONHSAT041499 and serum IFN-gamma to diagnose and distinguish gastric cancer and healthy volunteers, the AUC can be increased to 0.793 or 0.805, and when using the combination of serum NONHSAT089447 and NONHSAT041499 with serum IFN-gammato diagnose and distinguish gastric cancer and healthy volunteers, the AUC can be increased to 0.921. The technical personnel in the field knows that when the area under the ROC curve is in a range of1.0-0.5 and AUC is less than 0.5, the closer AUC is to 1, the better diagnosis effect is obtained, when the AUC is in a range of 0.5-0.7, the accuracy is lower, when the AUC is in a range of 0.7-0.9,a certain accuracy is obtained and when the AUC is greater than or equal to 0.9, high accuracy is obtained and thus the combination of serum IFN-gamma and serum NONHSAT089447 and / or NONHSAT041499 canbe used for preparation of the gastric cancer diagnostic kit.

Description

technical field [0001] The invention belongs to the field of gene diagnosis and relates to the development of a diagnostic kit, in particular to the use of a serum IFN-γ and LncRNAs composition for preparing a gastric cancer diagnostic kit. Background technique [0002] The incidence of gastric cancer ranks the second among malignant tumors in my country, and the death toll accounts for 14.33% of cancer cases, ranking the third, second only to lung cancer and liver cancer. It can be seen that gastric cancer is the focus of tumor prevention and treatment. With the widespread clinical application of tumor markers, more and more scholars have found that tumor markers play an important role in the prevention and treatment of cancer. IFN-γ is an important cytokine involved in immune regulation. It is generally secreted by activated T lymphocytes and can affect the growth of tumor cells. The expression level of IFN-γ is obviously abnormal in tumor patients. Based on this, many ...

AI Technical Summary

Problems solved by technology

[0003] Serum IFN-γ has been used as a diagnostic marker in the diagnosis of gastric cancer (Diagnostic value of combined detection of serum IFN-γ and tumor markers for gastric cancer, Biomedical Engineering and Clinical, Volume 20, Issue 2, March 2016), However, the accuracy of using serum IFN-γ alone to diagnose gastric cancer is low and the clinical value is low

Images