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Silymarin extracting method

A technology of silymarin and an extraction method, which is applied in the field of extraction of silymarin and achieves the effects of good drying effect, improved yield and high yield

Inactive Publication Date: 2018-03-06
江苏健佳药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Currently, there is a lack of an extraction method for silymarin with a high yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for extracting silymarin of the present invention comprises the following steps: (1) cleaning the silymarin seeds to be extracted, draining the water, and then performing microwave drying to reduce the water content to below 10%;

[0027] (2) The milk thistle seeds were pulverized, sieved with a 40-mesh sieve, and puffed; the microwave drying frequency was 1000 MHz, and the drying time was 4 minutes. The parameters of the screw extrusion puffing treatment are: screw speed 220r / min, extrusion temperature 125°C, feed rate 15r / min; air puffing technology processing parameters are: operating temperature 80°C, puffing pressure difference 300kPa, puffing The time is 75 minutes; the technical parameters of microwave puffing are: microwave power 2000W, processing time 3 minutes.

[0028] (3) Supercritical CO 2 Refining: The silymarin seeds are fed into supercritical CO 2 In the device, after the first extraction and the second extraction, the extract is collected to ...

Embodiment 2

[0031] The difference between Example 2 and Example 1 is that a method for extracting silymarin of the present invention comprises the following steps: in step (2), pulverizing the seeds of silymarin, sieving with a 50-mesh sieve, and puffing; The frequency of microwave drying is 800MHz, and the drying time is 3min. The parameters of the screw extrusion puffing treatment are: screw speed 180r / min, extrusion temperature 115°C, feed rate 25r / min; air puffing technology processing parameters are: operating temperature 70°C, puffing pressure difference 200kPa, puffing The time is 50 minutes; the technical parameters of microwave puffing are: microwave power 1000W, processing time 4 minutes.

[0032] In step (3), supercritical CO 2 Refining: The silymarin seeds are fed into supercritical CO 2 In the device, after the first extraction and the second extraction, the extract is collected to obtain the crude product of silymarin; CO 2 Supercritical extraction, first extraction: flui...

Embodiment 3

[0035] The difference between embodiment 3 and embodiment 1 is:

[0036] A method for extracting silymarin of the present invention comprises the steps of: in step (2), pulverizing the silymarin seeds, sieving through a 60-mesh sieve, and puffing; the microwave drying frequency is 900 MHz, and the drying time is 2 min . The parameters of the screw extrusion puffing treatment are: screw speed 200r / min, extrusion temperature 145°C, feed rate 20r / min; air puffing technology processing parameters are: operating temperature 60°C, puffing pressure difference 400kPa, puffing The time is 65 minutes; the technical parameters of microwave puffing are: microwave power 1600W, processing time 2 minutes.

[0037] In step (3), supercritical CO 2 Refining: The silymarin seeds are fed into supercritical CO 2 In the device, after the first extraction and the second extraction, the extract is collected to obtain the crude product of silymarin; CO 2 Supercritical extraction, first extraction:...

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PUM

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Abstract

The invention discloses a silymarin extracting method. The silymarin extracting method comprises the following steps: (1) washing silybum marianum seeds to be extracted; draining off; and microwave drying until the water content is reduced to be less than 10%; (2) crushing the silybum marianum seeds; sieving through a sieve with 40-80 meshes; and expanding; (3) performing supercritical CO2 refining, namely, feeding the silymarin seeds into a supercritical CO2 device; extracting twice; and collecting extracting solution to obtain rough silymarin product; and (4) freezing and centrifuging; centrifuging the frozen rough silymarin product for 20-30 minutes through a high-speed freezing centrifuging machine; purifying; washing under the temperature of 40-50 DEG C; and drying to obtain silymarin. The method is high in yield, quick, efficient, free from any solvent residues, and free from pollutions on extracted substances; the whole process is simple, complete in separation, green and environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of silymarin, in particular to a method for extracting silymarin. Background technique [0002] Milk thistle (Silybum marianum (L.) Gaertn) is a plant of the genus Silybum in the family Asteraceae. It is an excellent medicinal plant and oil plant. The dried ripe fruit is used as medicine. It tastes bitter and cool, and returns to the liver and gall bladder. , has the functions of clearing heat and detoxifying, soothing the liver and promoting gallbladder, and is used to treat damp-heat in the liver and gallbladder, hypochondriac pain, and jaundice. [0003] Silymarin can be extracted from the seeds of milk thistle. Silymarin is mainly distributed in the seed shell, the content is about 3% to 5% in the shell, and the content in the seed kernel is very small. Silymarin is a flavonoid compound, and its main components are silybin, iso-silibinin, silybinin and silybinin, etc., and silybin is the main component...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
CPCC07D407/04Y02P20/141Y02P20/54
Inventor 周勇周晓娟梁呈元
Owner 江苏健佳药业有限公司
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