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Medicine treating hemicranias and preparation method thereof

A migraine and drug technology, applied in the medical field, can solve problems such as unsatisfactory clinical effect and single treatment mechanism, and achieve the effect of controlling and preventing migraine attacks, low cost, and safe use

Inactive Publication Date: 2018-03-13
莫玉艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the single treatment mechanism of the above-mentioned unilateral preparations, the clinical effect is not satisfactory, and more effective drugs for the treatment of migraine still need to be found.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of preparation of the medicine for treating migraine, comprises the following steps:

[0022] a. By weight, take the following raw materials: naproxen 10g, amitriptyline 20g, polyvinylpyrrolidone 10g, carboxymethylcellulose calcium 8g, stearic acid 0.5g, sucrose 0.3g, sulfite 0.1g, methylcellulose 5g and cellulose acetate phthalate 2g;

[0023] b. Mix naproxen, amitriptyline, carboxymethylcellulose calcium, sucrose, sulfite, methylcellulose and cellulose acetate phthalate, and prepare it with 5% polyvinylpyrrolidone solution Granules, dried in an oven at 60°C, sieved and granulated;

[0024] c. Add stearic acid to the granules described in step b, mix well, and directly compress into tablets with a tablet weight of 0.2 g.

Embodiment 2

[0026] A kind of preparation of the medicine for treating migraine, comprises the following steps:

[0027] a. By weight, take the following raw materials: naproxen 30g, amitriptyline 15g, polyvinylpyrrolidone 5g, carboxymethylcellulose calcium 5g, stearic acid 0.8g, sucrose 0.1g, sulfite 0.3g, methylcellulose 2g and cellulose acetate phthalate 5g;

[0028] b. Mix naproxen, amitriptyline, carboxymethylcellulose calcium, sucrose, sulfite, methylcellulose and cellulose acetate phthalate, and prepare it with 5% polyvinylpyrrolidone solution Granules, dried in an oven at 60°C, sieved and granulated;

[0029] c. Add stearic acid to the granules described in step b, mix well, and directly compress into tablets with a tablet weight of 0.2 g.

Embodiment 3

[0031] A kind of preparation of the medicine for treating migraine, comprises the following steps:

[0032] a. By weight, take the following raw materials: naproxen 40g, amitriptyline 15g, polyvinylpyrrolidone 5g, carmellose calcium 5g, stearic acid 0.5g, sucrose 0.3g, sulfite 0.2g, methylcellulose 2g and cellulose acetate phthalate 5g;

[0033] b. Mix naproxen, amitriptyline, carboxymethylcellulose calcium, sucrose, sulfite, methylcellulose and cellulose acetate phthalate, and prepare it with 5% polyvinylpyrrolidone solution Granules, dried in an oven at 60°C, sieved and granulated;

[0034] c. Add stearic acid to the granules described in step b, mix well, and directly compress into tablets with a tablet weight of 0.2 g.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and particularly discloses a medicine treating hemicranias and a preparation method thereof. The medicine comprises the following raw materials in parts by weight: 10 to 50 parts of naproxen, 10 to 20 parts of amitriptyline, 5 to 15 parts of povidone, 2 to 8 parts of calcium carboxymethylcellulose, 0.1 to 1 part of stearic acid, 0.1 to 0.5part of saccharose, 0.1 to 0.5 part of sulfite, 2 to 5 parts of methylcellulose, and 2 to 5 parts of cellulose acetate phthalate. The medicine selects clinically common single-dosage drugs as raw materials, the maximum content of each component does not exceed that in the regulations of a pharmacopeia, the medicine is safe to use and scientific in formula, does not have obvious side effect, and islow in cost.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a medicine for treating migraine and a preparation method thereof. Background technique [0002] Migraine (Migraine) refers to recurrent pulsating headache on one or both sides, which is a common idiopathic headache in clinical practice. It is a recurrent disease caused by primary abnormal regulation of intracranial vasomotor and neurological functions. The male to female ratio of the incidence of migraine is 1:4. Its pathogenesis is not yet fully understood, and it may be related to factors such as heredity, endocrine, metabolism, diet and spirit. At present, the incidence rate of migraine is 10%-15% in European and American countries, and 0.06% in China. Experts predict that by 2017, migraine will become one of the diseases with the highest incidence in my country, and it has seriously affected people's quality of life. [0003] Naproxen (Naproxen) is an antipy...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/135A61K9/20A61K47/38A61P25/06A61P29/00
CPCA61K31/192A61K9/2054A61K31/135A61K2300/00
Inventor 莫玉艳
Owner 莫玉艳
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