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Dialysis solution or substitution solution containing an organic phosphoric acid ester

A technology of organic ester, orthophosphate, applied in the field of dialysis solution or replacement solution

Active Publication Date: 2018-03-27
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A problem in electrolytes which, in addition to calcium or magnesium, also contain bicarbonate as a buffer is that under defined conditions, especially at relatively high pH values ​​and high temperatures, insoluble carbonates can be formed, which is unexpected
[0004] If bicarbonate-buffered dialysis solutions containing calcium or magnesium ions contain phosphate ions in addition to bicarbonate ions, there is also a potential hazard of being able to form poorly soluble phosphate compounds

Method used

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  • Dialysis solution or substitution solution containing an organic phosphoric acid ester
  • Dialysis solution or substitution solution containing an organic phosphoric acid ester
  • Dialysis solution or substitution solution containing an organic phosphoric acid ester

Examples

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Embodiment 1

[0093] The present invention proposes a phosphate source that is rapidly absorbed by the body, stabilizes the solution and does not constitute poorly soluble phosphates.

[0094] This is illustrated below by means of the addition of a mixture of glycerol-2-orthophosphate and glycerol-3-orthophosphate (hereinafter abbreviated to “glycerol orthophosphate”) to the dialysis solution. This substance is representative of organic esters of phosphoric acid. Figure 9 Structural formulas of glycerol-2-orthophosphate and glycerol-3-orthophosphate are shown.

[0095] exist Figure 10 The stability of various "multBic" solutions spiked with different concentrations of glycerol orthophosphate is shown in . As can be seen from this, as the concentration of glycerol orthophosphate increases, the pH of the solution max and t G value rises. Here, it is striking that at a concentration of 0.5mmol / L, the pH max Already significantly elevated relative to conventional "multBic" solutions. I...

Embodiment 2

[0108] In addition, orthophosphate was added to the GP-modified "multBic" solution of Comparative Example 1.

[0109] exist Figure 13 The stability of the following various solutions is shown in: Unmodified "multBic" solution according to Comparative Example, P-modified "multBic" solution according to Comparative Example, GP-modified "multBic" according to Example 1 solution and a GP-modified "multBic" solution additionally doped with 0.1 mmol / L of orthophosphate. As is evident from the figure, for the solution doped with glycerol orthophosphate and the solution doped with orthophosphate give an overproportion of improve.

[0110] Values ​​are obtained as described above according to the "rapid controlled precipitation method" at T=40° C. as detection by means of pH measurement or, if this is not applicable, by means of turbidity measurement and / or particle measurement.

[0111] Figure 14 On the one hand, the stability of the unmodified "multBic" solution without glycero...

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Abstract

The invention relates to a dialysis solution or substitution solution which contains bicarbonate ions and calcium and / or magnesium ions, the dialysis solution or the substitution solution further containing an organic phosphoric acid ester.

Description

technical field [0001] The invention relates to a bicarbonate-buffered dialysis solution or replacement solution comprising calcium and / or magnesium ions and organic esters of phosphoric acid. Background technique [0002] Bicarbonate-buffered dialysis solutions containing calcium or magnesium ions usually contain physiologically effective concentrations of electrolytes, buffers, and glucose. A problem in electrolytes which, in addition to calcium or magnesium, also contain bicarbonate as a buffer is that under defined conditions, especially at relatively high pH values ​​and high temperatures, insoluble carbonates can be formed, which is unexpected. [0003] Dialysis solutions with a physiological phosphate content are used in acute dialysis in order to regulate the patient's phosphate balance and prevent hypophosphatemia. Based on experience derived from clinical applications, medically reasonable phosphate ester concentrations lie in the range of 0.60 mmol / L to 1.45 mmo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/661A61K33/06A61K33/10A61K33/42A61M1/16A61M1/28B65D30/22A61J1/10A61P7/08
CPCA61J1/10A61K9/08A61K31/661A61K33/06A61K33/10A61K33/42A61M1/1654A61M1/287B65D31/12A61K2300/00A61P7/08
Inventor 约亨·胡珀特帕斯卡尔·马西斯罗伯特·贝尔利希罗伯特·波尔迈尔
Owner FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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