Unlock instant, AI-driven research and patent intelligence for your innovation.

A transdermal absorption preparation for treating urinary tract infection caused by drug-resistant bacteria

A technology for transdermal absorption preparation and urinary tract infection, which is applied in the field of medicine and can solve the problems such as less antibacterial drug-resistant ingredients, reduced cell membrane permeability, and neglect of the research and development direction of antibacterial auxiliary drugs.

Active Publication Date: 2018-10-02
郑士平
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on antibacterial drugs of traditional Chinese medicine has less research on inhibiting bacterial drug resistance components, ignoring the important research and development direction of antibacterial drug auxiliary drugs (HuiTeng, Won Y. Lee. Antibacterial and antioxidant activities and chemical compositions of volatile oils extracted from SchisandrachinensisBaill. seedsusingsimultaneous distillation extraction method, and comparison with Soxhlet and microwave-assisted extraction. Bioscience, Biotechnology, and Biochemistry. 2014,78(1):79-85)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A transdermal absorption preparation for treating urinary tract infection caused by drug-resistant bacteria
  • A transdermal absorption preparation for treating urinary tract infection caused by drug-resistant bacteria
  • A transdermal absorption preparation for treating urinary tract infection caused by drug-resistant bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Preparation of Gel Transdermal Absorption Preparation

[0059]

[0060] Preparation:

[0061] (1) Take hydroxypropyl methylcellulose and add distilled water, let it stand for 8 hours to swell, and make a gel matrix;

[0062] (2) Take meropenem and add distilled water to dissolve to make liquid dispersion system A;

[0063] (3) Take gomisin A, add glycerin, polyethylene glycol 400, sodium bisulfite, and 95% ethanol and stir evenly to make liquid dispersion system B;

[0064] (4) Add the liquid dispersion system A and the liquid dispersion system B into the gel matrix, grind while adding, add the remaining distilled water to dilute and stir evenly, and obtain the gel transdermal absorption preparation.

Embodiment 2

[0065] Example 2 Preparation of Gel Transdermal Absorption Preparation

[0066]

[0067] Preparation:

[0068] (1) Take hydroxypropyl methylcellulose and add distilled water, let it stand for 8 hours to swell, and make a gel matrix;

[0069] (2) Take meropenem and add distilled water to dissolve to make liquid dispersion system A;

[0070] (3) Take gomisin A, add glycerin, polyethylene glycol 400, sodium bisulfite, and 95% ethanol and stir evenly to make liquid dispersion system B;

[0071] (4) Add the liquid dispersion system A and the liquid dispersion system B into the gel matrix, grind while adding, add the remaining distilled water to dilute and stir evenly, and obtain the gel transdermal absorption preparation.

Embodiment 3

[0072] Preparation of embodiment 3 gel transdermal absorption preparation

[0073]

[0074] Preparation:

[0075] (1) Take hydroxypropyl methylcellulose and add distilled water, let it stand for 8 hours to swell, and make a gel matrix;

[0076] (2) Take meropenem and add distilled water to dissolve to make liquid dispersion system A;

[0077] (3) Take gomisin A, add glycerin, polyethylene glycol 400, sodium bisulfite, and 95% ethanol and stir evenly to make liquid dispersion system B;

[0078] (4) Add the liquid dispersion system A and the liquid dispersion system B into the gel matrix, grind while adding, add the remaining distilled water to dilute and stir evenly, and obtain the gel transdermal absorption preparation.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicine, and specifically relates to a transdermally absorbed preparation for treating urinary tract infection caused by drug resistant bacteria. The active component of the preparation is composed of meropenem, gomisin A, and / or a drug named as Weibobatan in Chinese. Preferably, the active component is composed of 160 to 240 parts by weight of meropenem and13 to 24 parts by weight of gomisin A, Gomisin A can reduce the resistance of bacteria on meropenem, and thus the antibacterial performance of meropenem is enhanced.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a transdermal absorption preparation for treating urinary tract infection caused by drug-resistant bacteria. Background technique [0002] Urinary tract infection, also known as urinary tract infection, is an infectious disease caused by bacteria invading the urothelium, usually accompanied by bacteriuria or pyuria. Urinary tract infection is divided into upper urinary tract infection and lower urinary tract infection, wherein upper urinary tract infection refers to pyelonephritis caused by bacterial infection, and lower urinary tract infection includes bacterial urethritis and cystitis. [0003] Urinary tract infection is a common infectious disease in clinical practice. For patients with complex factors, the incidence of urinary tract infection is 12 times higher than that of normal patients. Urological surgery is also often complicated by bacterial infections. Its pathogens are more ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/407A61K31/36A61K31/69A61K9/06A61K47/38A61K47/10A61P31/04
CPCA61K9/0014A61K9/06A61K31/36A61K31/407A61K31/69A61K47/10A61K47/38A61K2300/00
Inventor 郑士平宋秀艳宋安详高继友
Owner 郑士平