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Application of 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose to preparation of hypoglycemic drugs or foodstuffs

A technology of caffeoyl and pyranose, applied in the functions of food ingredients, food ingredients, food extraction, etc.

Inactive Publication Date: 2018-04-10
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese patent application number is 201710812986.6, which discloses the extraction and separation method of 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranose, and it has been proved by experiments that it has good antioxidant properties effect, can be applied to the research and development of anti-aging health care products, cosmetics, and drugs), at present, there is no report on the biological activity of this compound against α-glucosidase

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  • Application of 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose to preparation of hypoglycemic drugs or foodstuffs
  • Application of 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose to preparation of hypoglycemic drugs or foodstuffs
  • Application of 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose to preparation of hypoglycemic drugs or foodstuffs

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Embodiment 1

[0011] Chinese patent application number is 201710812986.6:

[0012] The extraction and separation method of 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranose comprises the following steps:

[0013] (1) The dry tuber root of False cohosh is crushed, and the volume concentration of 3 mass times is 95% ethanol aqueous solution heating and reflux extraction 2 times, and then the volume concentration of 3 mass times is 60% ethanol aqueous solution heating reflux extraction 1 time, Extract for 2 hours each time, filter, combine the filtrates, and recover the solvent under reduced pressure until the residue has no alcohol smell;

[0014] (2) Disperse the residue obtained in step (1) into distilled water to form an aqueous suspension with a residue mass concentration of 35%; Extract the suspension with 1.25 times the volume of ethyl acetate; recover the ethyl acetate extract to dryness under reduced pressure to obtain the ethyl acetate extract;

[0015] (3) Dissolve the ethyl acetate extr...

Embodiment 2

[0025] Determination of α-glucosidase inhibitory activity

[0026] Preparation of reaction solution

[0027] Prepare phosphate buffer: weigh 1.167g of dipotassium hydrogen phosphate and 0.9118 of potassium dihydrogen phosphate, add an appropriate amount of distilled water to dissolve, then use a volumetric flask to set the volume to 100mL, and prepare a phosphate buffer with pH=6.8 for later use.

[0028] Preparation of substrate PNPG (4-nitrophenyl-α-D-glucopyranoside) solution: Weigh 90.375mg PNPG, add appropriate amount of phosphate buffer (pH=6.8) to dissolve, and then use a volumetric flask to accurately dilute to 25mL, prepared as a 12mmol / L mother solution. Dilute the mother liquor to a 4mmol / L solution for subsequent use.

[0029] Preparation of α-glucosidase enzyme solution: dissolve freeze-dried enzyme powder (enzyme activity: 14u / mg) in phosphate buffer (pH=6.8), prepare a 0.15u / mL mother solution, and set aside.

[0030] Prepare Na 2 CO 3 Solution: weigh 2.12g...

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Abstract

The invention discloses application of 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose to preparation of hypoglycemic drugs or foodstuffs. 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose is as shown in aformula (I) which is described in the specification. Experimental results show that 1,3,6-tri-O-(E)-caffeoyl-beta-D-glucopyranose has better glucosidase inhibition activity than acarbose and can be used for preparation of antidiabetic food and drugs.

Description

technical field [0001] The invention relates to the use of extracting 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranose from plants in preparing hypoglycemic drugs or food. Background technique [0002] False cohosh (Aruncus sylvester Kostel.), belongs to Rosaceae (Rosaceae) Spiraeoideae subfamily (Spiraeoideae Agardh) and pseudo cohosh (Aruncus Adans.). The dried root of False cohosh is called "Golden Hair Sanqi", which is often used as a traditional Chinese medicine to treat muscle strain, and has the effect of relaxing tendons and activating collaterals. [0003] 1,3,6-Tri-O-(E)-caffeoyl-β-D-glucopyranose is a phenylpropanoid compound extracted and isolated from the dried root of Pseudocirush. The Chinese patent application number is 201710812986.6, which discloses the extraction and separation method of 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranose, and it has been proved by experiments that it has good antioxidant properties role, can be applied to anti-aging health care produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P3/10A23L33/105
CPCA23L33/105A23V2002/00A61K31/7024A23V2200/328A23V2250/21A23V2300/14A23V2300/38
Inventor 苏艳芳栗章彭魏子烨
Owner TIANJIN UNIV