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Technology for preparing stomach floating type slow-release hollow capsule

A technology of hollow capsules and preparation process, which is applied in the fields of capsule delivery, pharmaceutical formulation, drug delivery, etc. It can solve the problems of inability to effectively prolong the residence time of contents, inability to obtain gastric sustained-release performance, poor gastric buoyancy, etc., and achieve improved Bioavailability, improving demoulding pass rate, and prolonging the effect of residence time

Inactive Publication Date: 2018-04-13
马多浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, a small number of hollow capsules with sustained-release performance have appeared on the market, but their sustained-release performance is poor, and the gastric buoyancy is not good, and the retention time of the contents in the gastric juice cannot be effectively extended, and good gastric sustained-release cannot be obtained. performance

Method used

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  • Technology for preparing stomach floating type slow-release hollow capsule
  • Technology for preparing stomach floating type slow-release hollow capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 5g poloxamer 188 and 3g polyethylene glycol 4000, add 40-45 ℃ deionized water under stirring to completely dissolve poloxamer and polyethylene glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0027] (2) Preparation of stomach-floating sustained-release hollow capsules: Add 2 g of food-grade sodium polyacrylate and 1 g of hydrogenated palm oil to the prepared 15 g composite carrier, mix well, and use a microwave processor to treat with m...

Embodiment 2

[0030] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 10g Poloxamer 407 and 5g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0031] (2) Preparation of stomach-floating sustained-release hollow capsules: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g composite carrier, mix well, and use a microwave processor to treat with ...

Embodiment 3

[0034] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 10g Poloxamer 407 and 5g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5-10°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0035](2) Preparation of stomach-floating sustained-release hollow capsules: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g composite carrier, mix well, and use a microwave processor to treat with m...

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Abstract

The invention discloses a technology for preparing a stomach floating type slow-release hollow capsule, and relates to the technical field of capsule materials. The technology comprises the followingsteps: 1, preparing a composite carrier; and 2, preparing the stomach floating type slow-release hollow capsule. The hollow capsule prepared in the invention belongs to the stomach floating type slow-release hollow capsule, the content filled capsule can floats on the gastric juice for a long time after entering the human gastric juice, and the content is slowly released from the shell wall of a capsule shell and enters the gastric juice to perform the effects of the slow-release content, so the retention time of the content in the stomach is effectively prolonged, and the release time of drugeffect molecules in the content is prolonged.

Description

Technical field: [0001] The invention relates to the technical field of capsule materials, in particular to a preparation process of stomach-floating sustained-release hollow capsules. Background technique: [0002] Hollow capsules are usually composed of two capsule shells, a cap and a body, which are refined from medicinal gelatin and excipients. It is mainly used to hold solid medicines, such as self-made powders, health care products, medicines, etc., which solves the problems of difficult mouth and poor taste for users, and truly realizes that good medicines are no longer bitter. In recent years, hollow capsules have become more and more popular. First of all, the shape of capsules is slender and easy to swallow, making them the most popular dosage form for consumers; in addition, capsules can effectively cover up the unpleasant taste and smell of the contents, And can improve drug stability and bioavailability. [0003] At present, the empty capsules on the market ge...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/34A61K47/10
CPCA61K9/4816
Inventor 马多浩
Owner 马多浩
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