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Placenta extract gel preparation and preparation method thereof

A gel preparation and extract technology, which is applied in the field of placenta extract gel preparation and its preparation, can solve the problems affecting the quality and performance of the gel preparation, the adsorption of active ingredients, etc., so as to improve the transdermal absorption performance and reduce the Stimulating, dispersion-enhancing effect

Active Publication Date: 2018-04-27
吉林国健生命工程科学技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The commonly used matrices for gel preparation include hydroxypropylmethylcellulose, acrylic resin, etc., but a large amount of polymer pharmaceutical excipients will be used in the preparation process of the gel preparation, which seriously affects the quality and various properties of the gel preparation, and will Severe adsorption of active ingredients in placenta extract

Method used

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  • Placenta extract gel preparation and preparation method thereof
  • Placenta extract gel preparation and preparation method thereof
  • Placenta extract gel preparation and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 A gel formulation

[0040] The gel preparation is composed of a placenta extract and a gel matrix, each g of the gel matrix contains 100 ng of the placenta extract, and the gel matrix is ​​mainly composed of the following components by weight:

[0041] Deionized water 70g

[0042] Dextran 0.3g

[0043] Polyethylene glycol 4000 microcapsules

[0044]

[0045]

Embodiment 2

[0046] Example 2 A gel formulation

[0047] The gel preparation is composed of a placenta extract and a gel matrix, each g of the gel matrix contains 120ng of the placenta extract, and the gel matrix is ​​mainly composed of the following components by weight:

[0048] Deionized water 75g

[0049] Dextran 0.6g

[0050] Polyethylene glycol 4000 microcapsules

[0051]

[0052] Polyethylene glycol 4000 microcapsules are prepared by the following method: heat 0.7g xylitol anhydride monostearate in a water bath at 75°C, add 3.5g polyethylene glycol 4000 while it is hot, and rotate at 2000 revolutions / min, stirring for 20 minutes to obtain a homogenous substance, add cold petroleum ether to the homogenate, continue to stir, solidify the homogenate, filter, and dry naturally to obtain polyethylene glycol 4000 microcapsules with a particle size range of 25 μm.

Embodiment 3

[0053] Example 3 A gel formulation

[0054] The gel preparation is composed of a placenta extract and a gel matrix, each g of the gel matrix contains 130ng of the placenta extract, and the gel matrix is ​​mainly composed of the following components by weight:

[0055] Deionized water 80g

[0056] Dextran 0.4g

[0057] Polyethylene glycol 4000 microcapsules

[0058]

[0059] The preparation method of the gel preparation is:

[0060] S1: Preparation of polyethylene glycol 4000 microcapsules: the same as in Example 2;

[0061] S2: Dissolve polyethylene glycol 4000 microcapsules in 80g deionized water, leave it to stand still, add 2.5g glycerin, 0.4g dextran and 1.5g choline chloride, stir for 10min, rotate speed 3500 rpm, and make a gel The gel matrix is ​​obtained by adding the placenta extract in an amount containing 120ng of the placental extract per g of the gel matrix, and stirring uniformly.

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Abstract

The invention provides a placenta extract gel preparation which comprises a placenta extract and a gel substrate. Each gram of the gel substrate comprises 100-150ng of placenta extract, and the gel substrate mainly comprises deionized water, dextran, polyethylene glycol 4000, glycerol and choline chloride. According to the placenta extract gel preparation, mixture of a polyethylene glycol 4000 micro-capsule, the dextran and the choline chloride is added into the gel substrate, stability of the gel preparation can be improved, and the gel preparation can be used for preserving the placenta extract for a long time without affecting the survival rate of active components in the placenta extract.

Description

Technical field [0001] The invention belongs to the technical field of gel preparations, and particularly relates to a placenta extract gel preparation and a preparation method thereof. Background technique [0002] Placental extract is a variety of life active substances secreted by placental stem cells after special culture, including proteins, peptides, cell growth factors and biologically active factors. After special separation and extraction technology and processing methods, A variety of effective active ingredients are concentrated. A variety of life active components in placenta extract have complex physiological effects, each component can have an impact on many tissues and organs, and the improvement of each form of physiological function is not a single factor, but requires multiple factors. Coordinating each other, so placental extract has better anti-aging and activating body functions than a single cytokine. [0003] Placental extract preparations are generally fre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/04A61K8/98A61K8/34A61K8/37A61K8/41A61K8/55A61K8/60A61K8/73A61K8/86A61Q19/08
CPCA61K8/042A61K8/345A61K8/375A61K8/416A61K8/553A61K8/60A61K8/732A61K8/86A61K8/982A61Q19/08
Inventor 刘俊江曹毓琳时兆田白志惠
Owner 吉林国健生命工程科学技术有限公司