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Application of Traditional Chinese Medicine Composition in Japanese Encephalitis

A technology of Japanese encephalitis and composition, applied in the application field of ginkgolide composition in the prevention/treatment of Japanese encephalitis

Active Publication Date: 2020-03-31
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no related reports that Ginkgo biloba extract can treat or prevent Japanese encephalitis

Method used

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  • Application of Traditional Chinese Medicine Composition in Japanese Encephalitis
  • Application of Traditional Chinese Medicine Composition in Japanese Encephalitis
  • Application of Traditional Chinese Medicine Composition in Japanese Encephalitis

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Embodiment Construction

[0015] Hereinafter, the present invention will be described in more detail through specific embodiments, so as to better understand the solutions of the present invention and the advantages of various aspects thereof. However, the content of the specific embodiments described below is only for the purpose of illustration, rather than limiting the present invention.

[0016] It should be noted that if the specific conditions are not specified, they are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used without indicating the manufacturer, can be obtained from the market. conventional products. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0017] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addit...

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Abstract

The invention relates to application of a bilobalide composition in the preparation of a drug for treating Japanese encephalitis. An in-vitro experiment shows that the bilobalide composition is capable of inhibiting the pathological change of a cell BHK-21 infected by JEV. Furthermore, by applying the composition, neurobehavioral symptoms of a suckling mouse can be obviously improved, and the volume and water content of an infected region are reduced to different degrees. Besides, the bilobalide composition is further capable of reducing the expression of TNF-alpha and IL-2 in a dose-dependentmanner. Therefore, the experiment proves that the bilobalide composition is capable of treating / preventing Japanese encephalitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of a ginkgolide composition in preventing / treating Japanese encephalitis. Background technique [0002] Japanese encephalitis virus (JEV) is the pathogen of Japanese encephalitis, first discovered in Japan in 1870, also known as Japanese encephalitis virus. JE is a zoonotic natural foci disease, and it is the main viral encephalitis in Pacific countries. The third generation of Culex rhinorrhea is the main vector. When the immunity is weak, the virus can destroy the blood-brain barrier and invade the central nervous system, showing symptoms such as high fever, convulsions, convulsions, disturbance of consciousness and respiratory failure. Globally, about 30,000 to 50,000 people are infected every year, and 10,000 to 15,000 people die. About 5% to 20% of severe patients have neurological sequelae. According to the report of the Ministry of Health, in 2015, a to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P31/14
CPCA61K31/365Y02A50/30
Inventor 萧伟李良王振中刘秋许治良周军周建明章晨峰王团结胡晗绯
Owner JIANGSU KANION PHARMA CO LTD
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