Acylhydrazone copper (II) complex and preparation method and application in inhibiting urease activity thereof

A technology of copper acylhydrazone and complexes, which is applied in the field of copper acylhydrazone complexes and their preparation, can solve the problems of toxic and side effects, difficulty in popularization and application, and achieves the effects of good stability, mild experimental environment and high yield

Inactive Publication Date: 2018-05-08
LIAONING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Some metal salts have strong urease inhibitory activity, especially copper salts, silver salts, etc., but as heavy metal ions, they also have strong toxic and side effects and are difficult to popularize and apply

Method used

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  • Acylhydrazone copper (II) complex and preparation method and application in inhibiting urease activity thereof
  • Acylhydrazone copper (II) complex and preparation method and application in inhibiting urease activity thereof
  • Acylhydrazone copper (II) complex and preparation method and application in inhibiting urease activity thereof

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Embodiment approach

[0036] A detailed embodiment of the present invention is as follows:

[0037] Step 1: Dissolve 10.7 g (0.1 mol) of pyridine-2-carbaldehyde and 21.5 g (0.1 mol) of 4-bromobenzoylhydrazide in a round-bottomed flask under stirring at 20±10 ˚C in 100 mL of anhydrous methanol, then mixed and stirred at 20±10 °C, TLC followed the reaction, after 1 h of reaction, the solvent was distilled off under reduced pressure, the obtained solid crude product was washed with cold methanol, dried, and the obtained solid The crude product was dissolved in methanol and recrystallized to obtain a colorless crystalline compound with the structure shown in Formula 1. Yield 95%. 1 H NMR (DMSO- d 6 , 500 MHz) δ (ppm): 8.62 (d, 1H, Py H ), 8.48 (m, 1H,Py H ), 7.95 (d, 2H, Ar H ), 7.83 (m, 3H, Py H and Ar H ), 7.65 (t, 1H, Py H ), 7.43(s, 1H, C H =N), 4.06 (s, 1H, N H ). 13 C NMR (DMSO- d 6 , 300 MHz) δ IR data (KBr, cm -1 ): 3230, 1654, 1589, 1545, 1466, 1432, 1323, 1305, 1279, 114...

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Abstract

The invention discloses an acylhydrazone copper (II) complex and a related preparation method and application in inhibiting urease activity thereof. The preparation method is as shown in the description. According to the acylhydrazone copper (II) complex, the acylhydrazone copper (II) complex has a higher inhibiting effect on the urease activity, the inhibition ratio is 95.1% under the concentration of 50 microgram per milliliter, and the IC50 value is 0.18+ / -0.02 microgram per milliliter.

Description

technical field [0001] The invention relates to the technical field of urease inhibitors, in particular to an acylhydrazone copper (II) complex and its preparation method and its application in inhibiting urease activity. Background technique [0002] Acylhydrazones are a special class of Schiff base compounds containing –CH=N–NH–C(O)–functional groups, which are products formed by the condensation reaction of hydrazides with aldehydes or ketones. Acylhydrazone compounds have a variety of excellent biological activities, and reports have shown that they also have good performance in inhibiting urease activity. [0003] Some metal salts have strong urease inhibitory activity, especially copper salts, silver salts, etc., but as heavy metal ions, they also have strong toxic and side effects and are difficult to popularize and apply. [0004] Acylhydrazones have donor atoms such as O and N, and are easy to form complexes with various transition metal ions. Acylhydrazones also ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61P43/00
CPCC07F1/005
Inventor 由忠录郭思含于慧媛董婧雯潘琳
Owner LIAONING NORMAL UNIVERSITY
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