An organ-on-a-chip unit with a pipeline network

Abstract

An organ chip unit containing a pipeline network, comprising: at least one layer of chips containing an input pipeline network for the input, diversion and diffusion of substances; at least one layer of chips containing an output pipeline network for Diffusion, confluence and output of substances; at least one layer of chamber chips, containing solid organ tissues; at least two layers of microporous membranes, separated by microporous membranes between solid organ tissues and input and output pipeline networks; at least Two layers of barrier cells, the barrier cells are in the input and output pipeline network, adhered to the microporous membrane; two layers of sealing plates are used to realize encapsulation. Using the organ chip unit, it is possible to simulate the process that substances enter the tissue after being shunted through various pipeline networks such as blood vessels / lymphatic vessels / bronchial / gland secretion network, and then gradually converge after being metabolized in the tissue. At the same time, it is more accurate when applied to drug screening, case study and physiological analysis.

Description

technical field [0001] The invention relates to a human or animal bionic system, in particular to an organ chip unit containing a pipeline network. Background technique [0002] The construction of bionic tissue / organ / system models in vitro through microfluidic chips has the advantages of low consumption and fast response, which can not only make up for the inaccurate animal experiments and the high cost of clinical experiments, but also make up for the slow response of animal / human experiments. The disadvantage of long cycle, so it has been widely used. [0003] However, the current organ-on-a-chip is a simple accumulation of cells, and does not have the in vivo process of material transfer pipeline shunt-diffusion metabolism-pipe collection, that is, the current organ-on-a-chip does not have pipeline networks such as arteries, veins, and lymphatic vessels. There are inaccuracies in bionic analysis. Contents of the invention [0004] The main purpose of the present inve...

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Problems solved by technology

[0003] However, the current organ-on-a-chip is a simple accumulation of cells, and does not have the in vivo process of material transfer pipeline shunt-diffusion metabolism-pipe collection, that is, the current organ-on-a-chip does not have pipeline networks such as arteries, veins, and lymphatic vessels. There are inaccuracies in bionic analysis

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