Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of extraction method of high-purity andrographolide

A technology of andrographolide and extraction method, applied in the direction of organic chemistry, etc., can solve the problems of poor safety, large amount of organic solvent used, low yield of andrographolide, etc.

Active Publication Date: 2021-05-07
BEIHAI KAIYUAN BIOLOGICAL TECH
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to provide a method for extracting andrographolide, which uses dynamic countercurrent extraction technology to extract andrographolide, effectively solving the problems of low yield of andrographolide, large amount of organic solvent used, high extraction cost, and poor safety.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of extraction method of high-purity andrographolide
  • A kind of extraction method of high-purity andrographolide
  • A kind of extraction method of high-purity andrographolide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Pulverization: take 100Kg of Andrographis paniculata, and pulverize it to an average length of 3 cm.

[0036] (2) Extraction: Inject 500L of 95% ethanol into the extraction cylinder. When the liquid level of the solvent reaches 3 / 4 of the diameter of the cylinder, open the steam valve to heat the solvent. When the temperature reaches 60°C, start to put Andrographis paniculata in the extraction cylinder. Grass powder, control the rotation speed of the shaft of the extraction cylinder to 3r / min, and the spiral belt fixed on the shaft slowly pushes the Andrographis paniculata powder from the front of the unit to the rear, and at the same time, the extraction solvent enters the filter from the liquid inlet at the end of the unit, and is discharged from the back of the cylinder. The end passes through the moving material and flows to the front end. The solid-liquid two-phase material is fully contacted in this reverse movement. When the Andrographis paniculata powder is c...

Embodiment 2

[0044] (1) Pulverization: take 100Kg of Andrographis paniculata, and pulverize it to an average length of 2 cm.

[0045] (2) Extraction: Inject 500L of 95% methanol into the extraction cylinder. When the liquid level of the solvent reaches 3 / 4 of the diameter of the cylinder, open the steam valve to heat the solvent. When the temperature reaches 60°C, start to put Andrographis paniculata into the extraction cylinder. Grass powder, control the rotation speed of the shaft of the extraction cylinder to 3r / min, and the spiral belt fixed on the shaft slowly pushes the Andrographis paniculata powder from the front of the unit to the rear, and at the same time, the extraction solvent enters the filter from the liquid inlet at the end of the unit, and is discharged from the back of the cylinder. The end passes through the moving material and flows to the front end. The solid-liquid two-phase material is fully contacted in this reverse movement. When the Andrographis paniculata powder i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for extracting high-purity andrographolide. After pulverizing andrographolide, the andrographolide is extracted by a dynamic countercurrent extraction method, decolorized through a chromatographic column of activated carbon, recrystallized, and dried to obtain the andrographolide. The yield of andrographolide in the invention is above 82.9%, the purity is above 99.6%, the solvent consumption is small, the product purity is high, and the impurity content is small.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, in particular to a method for extracting high-purity andrographolide based on the principle of dynamic countercurrent extraction technology. Background technique [0002] Andrographis paniculata Nees is a perennial or annual herb of the family Andrographis paniculata Nees. It is also known as Yijianxi, Zhanshejian, Zhantongjian, bitter grass, bitter gall grass, square grass, Larvae, and cone herb. The whole plant is used as medicine. Andrographis paniculata is bitter in taste and cold in nature, and it is a commonly used traditional Chinese medicine, and it is one of the first-selected antiviral drugs. [0003] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. The molecular formula is C 20 h 30 o 5 , white prismatic or flaky cryst...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/60
CPCC07D307/60
Inventor 石清东莫丽影
Owner BEIHAI KAIYUAN BIOLOGICAL TECH