Short peptide capable of realizing brain-targeting drug delivery and application of short peptide

A brain-targeting, short peptide technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, peptides, etc., can solve the problem of OX26 immunogenicity and animal species selectivity, short insulin half-life , hypoglycemia and other problems, to achieve the effect of improving blood-brain barrier permeability, good biocompatibility, and high affinity

Active Publication Date: 2018-06-01
NORTHEASTERN UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, the currently studied receptors (transferrin, insulin, monoclonal antibody OX26, etc.) all have some shortcomings: under physiological conditions, transferrin receptors may be saturated by endogenous transferrin; The half-life in vivo is very short, and high concentration will cause hypoglycemia; OX26 has strong immunogenicity and animal species selectivity, etc.

Method used

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  • Short peptide capable of realizing brain-targeting drug delivery and application of short peptide

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Embodiment Construction

[0021] The present invention will be described in further detail below in conjunction with specific examples, which are explanations of the present invention rather than limitations.

[0022] In the first aspect, the specific embodiments of the present invention provide a short peptide having the following amino acid sequence:

[0023] Ile-Thr-Pro-Thr-Arg-Lys-Ser, as shown in SEQ ID NO:1.

[0024] The above-mentioned short peptide has high affinity to the blood-brain barrier, strong specificity, and good biocompatibility, so it can be used as a carrier for targeted therapy of drugs for diseases of the brain and nervous system.

[0025] In the second aspect, the specific embodiments of the present invention provide a pharmaceutical composition comprising a short peptide having the following amino acid sequence:

[0026] Ile-Thr-Pro-Thr-Arg-Lys-Ser, as shown in SEQ ID NO:1.

[0027] Therefore, in the third aspect of the specific embodiments of the present invention, the use of...

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Abstract

The invention provides a short peptide capable of realizing brain-targeting drug delivery and application of the short peptide. An amino acid sequence of the short peptide is Ile-Thr-Pro-Thr-Arg-Lys-Ser, shown as SEQ ID NO: 1. Immunofluorescence test results show that the short peptide provided by the invention has good brain-targeting drug delivery characteristic and can improve the blood-brain barrier permeability of the existing drug.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a short peptide, in particular to a short peptide capable of realizing brain-targeted drug delivery and an application thereof. Background technique [0002] Alzheimer's disease (Alzheimer's Disease AD) is a complex neurodegenerative disease, common in middle-aged and elderly people, and is the main cause of senile dementia. Alzheimer's disease develops in stages and gradually deteriorates memory, reasoning, judgment, and language skills, and the ability to perform simple tasks. At present, Alzheimer's disease is gradually showing a trend of rejuvenation, which has created enormous pressure on individuals, families and society. Therefore, research on the treatment of Alzheimer's disease has become urgent. [0003] Parkinson's disease (PD) is a common neurodegenerative disease with an average age of onset of around 60 years old. The main pathological change of creeping monk's d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K47/42A61K47/64A61K38/08A61P25/28A61P25/00A61P25/08A61P25/24A61P25/16
CPCA61K47/42C07K7/06
Inventor 李由张晓雨高慧玲钟曼丽王占友
Owner NORTHEASTERN UNIV
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