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Plasma miRNA marker related to pancreatic cancer assisted diagnosis and application of marker

A technology for auxiliary diagnosis and pancreatic cancer, applied in the fields of genetic engineering and oncology, it can solve the problems of inconsistent research results, and achieve the effect of high sensitivity and specificity, minimally invasive access, and easy access.

Active Publication Date: 2018-06-01
朱伟
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to differences in research methods and included populations, the results of the studies were not completely consistent.

Method used

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  • Plasma miRNA marker related to pancreatic cancer assisted diagnosis and application of marker
  • Plasma miRNA marker related to pancreatic cancer assisted diagnosis and application of marker
  • Plasma miRNA marker related to pancreatic cancer assisted diagnosis and application of marker

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Embodiment Construction

[0040] From 2010 to 2014, the inventor collected a large number of venous plasma samples from patients with pancreatic cancer and normal physical examination population from the First Affiliated Hospital of Nanjing Medical University, and selected 216 cases of pancreatic cancer and 220 cases of normal blood plasma samples by sorting out the sample data. The control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 44 cases of pancreatic cancer tissues and 44 cases of paracancerous tissues were retained. The selected patients' plasma samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were pathologically confirmed as pancreatic cancer. The demographic data and clinical data of these samples were collected systematically.

[0041] Refer to the flowchart ( figure 1 ), randomly selected 20 pan...

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Abstract

The invention discloses a plasma miRNA marker related to pancreatic cancer assisted diagnosis and an application of the marker. The marker includes one or more of miR-122-5p, miR-125b-5p, miR-192-5p,miR-193b-3p, miR-221-3p and miR-27b-3p. The plasma miRNA, as a novel biological marker, has the characteristics of being good in stability, minimally invasive and easy for acquisition, and high in sensitivity and specificity. The molecular markers, with development and utilization, can offer a direction for diagnosis and further treatment of various diseases including tumors. Through the research,the pancreatic cancer plasma miRNA markers, which has a clinical diagnosis potential and a prognosis capacity, can be obtained with high pertinence. Based upon researches, the reliability and the repeatability of the group of miRNA as noninvasive markers for diagnosing pancreatic cancer are proved.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a plasma miRNA marker related to auxiliary diagnosis of pancreatic cancer and its application. Background technique [0002] Pancreatic cancer (PC) is currently the sixth leading cause of cancer death in China and the seventh leading cause of cancer death worldwide. The disease has a poor prognosis, with a 5-year overall survival (OS) rate of less than 5%. Although systemic chemotherapy can prolong the survival of patients with pancreatic cancer, surgical resection is still the only curative treatment. However, less than 10% of pancreatic cancer patients are diagnosed at an early stage, and most patients lose the opportunity for surgery due to relatively advanced tumor staging. Early detection and intervention are key strategies to improve the long-term outcomes of patients with pancreatic cancer. Therefore, many studies have focused on biomarkers and molecular t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/113
Inventor 朱伟苗毅周鑫
Owner 朱伟
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