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A kind of preparation method of Enshi powder to remove bitterness

A technology of bitterness and enshi, which is applied in the field of preparation of enshi powder to remove bitterness, can solve the problem of inability to remove the bitterness of enshi powder, achieve the effect of improving the bitterness characteristics and avoiding incompatibility

Active Publication Date: 2021-03-16
北京中农华正兽药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problem that the bitterness of Enshi powder cannot be removed in the existing method, the present invention provides a preparation method for removing the bitterness of Enshi powder with excellent performance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation method for Enshi powder to remove bitterness, comprising the following steps:

[0016] Take the production of 100 kg of 20% enrofloxacin montmorillonite powder as an example.

[0017] Prescription: enrofloxacin hydrochloride 20 kg

[0018] montmorillonite powder 80kg

[0019] 160 kg of purified water.

[0020] Method process: Take 160 kg of purified water and put it into the liquid mixing tank with agitator, turn on the agitator, and adjust the speed at 1200 rpm, then slowly add 80 kg of montmorillonite powder into the liquid mixing tank to make montmorillonite powder. Add enrofloxacin hydrochloride slowly to the destoned suspension under the agitation of the stirrer, continue to stir for 45 minutes after the addition, and the stirring intensity is 800 rpm; stop stirring and let stand at room temperature for 60 minutes, take the supernatant For enrofloxacin content detection, the detection method refers to the content determination under P268 enrofloxac...

Embodiment 2

[0022] A preparation method for Enshi powder to remove bitterness, comprising the following steps:

[0023] Take the production of 100 kg of 25% enrofloxacin montmorillonite powder as an example.

[0024] Prescription: enrofloxacin hydrochloride 25 kg

[0025] montmorillonite powder 75 kg

[0026] 160 kg of purified water.

[0027] Method process: Take 160 kg of purified water and put it into the liquid mixing tank with agitator, turn on the agitator, adjust the speed at 1000 rpm, and then slowly add 75 kg of montmorillonite powder into the mixing liquid tank to make montmorillonite powder. Add enrofloxacin hydrochloride slowly to the destoned suspension under the agitation of the agitator, continue to stir for 60 minutes after the addition, and the stirring intensity is 1000 rpm; stop stirring and let stand at room temperature for 30 minutes, take the supernatant For enrofloxacin content detection, the detection method refers to the content determination under P268 enroflo...

Embodiment 3

[0029] A preparation method for Enshi powder to remove bitterness, comprising the following steps:

[0030] Take the production of 100 kg of 23% enrofloxacin montmorillonite powder as an example.

[0031] Prescription: enrofloxacin hydrochloride 23 kg

[0032] montmorillonite powder 77 kg

[0033] 160 kg of purified water.

[0034] Method process: Take 160 kg of purified water and put it into the liquid mixing tank with agitator, turn on the agitator, and adjust the speed at 1200 rpm, then slowly add 77 kg of montmorillonite powder into the mixing liquid tank to make montmorillonite powder. Add enrofloxacin hydrochloride slowly to the destoned suspension under the agitation of the stirrer, and continue to stir for 20 minutes after the addition, with a stirring intensity of 1200 rpm; stop stirring and let stand at room temperature for 50 minutes, take the supernatant For enrofloxacin content detection, the detection method refers to the content determination under P268 enrof...

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PUM

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Abstract

The invention provided a preparation method of enrofloxacin-montmorillonite powder for removing bitter taste. The preparation method comprises the steps of preparing a suspension liquid from montmorillonite powder and enrofloxacin hydrochloride through purified water, stirring, standing, extracting supernate, detecting the content of enrofloxacin hydrochloride, when the content is less than or equal to 0.02%, filtering moisture to obtain a filter cake, and drying the filter cake, so as to obtain the enrofloxacin-montmorillonite powder, wherein the ratio of parts by mass of montmorillonite powder to enrofloxacin hydrochloride is (3-5) to 1. Compared with a hard slaughtering manner at present, the animal welfare is greatly improved after the product of the invention is eaten by poultry.

Description

technical field [0001] The invention relates to the field of preparation of enrofloxacin and montmorillonite powder composition, in particular to a preparation method of enrofloxacin powder for removing bitterness. Background technique [0002] Enrofloxacin veterinary preparations include enrofloxacin injection, oral solution, soluble powder, tablet, etc., which have been widely used in pigs, chickens, ducks, fur animals, dogs, cats, and aquatic animals. Oral preparations are mostly used in chickens, but less used in pigs due to their bitter taste. In order to improve the palatability of enrofloxacin and improve the compliance of pigs taking medicine, people use the embedding method to make microcapsules and suspensions with hydrophobic materials; some of the results are too expensive, and some cannot be completely solved. Bitter taste of enrofloxacin. Therefore, the non-bitter enrofloxacin with simple process technology, easy access to auxiliary materials and low manufact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/02A61K31/496A61P31/04A61P1/12
CPCA61K9/143A61K31/496
Inventor 张萍
Owner 北京中农华正兽药有限责任公司
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