Microneedle introducible hyaluronic acid concentrate and preparation method thereof
A technology of hyaluronic acid and macromolecular hyaluronic acid, applied in skin care preparations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of limited effect, difficult hyaluronic acid, and inability to exert hyaluronic acid skin care and beauty effects, etc. problem, to achieve the effects of promoting proliferation and differentiation, restoring luster and elasticity, and improving hydration and water retention
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0033] The preparation method of the hyaluronic acid stock solution that can be introduced by microneedles of the present invention comprises the following steps in sequence:
[0034] Step 1) Weigh the following raw materials in parts by weight: water for injection, 0.1%-5.8% of 1,2-pentanediol and 0.05%-1.0% of thickener, add them into the emulsification pot in turn, turn on the cooling, and stir until completely dissolve;
[0035] Step 2) Weigh the following raw materials in parts by weight: glycerin 1.0%-10.0%, butanediol 0.1%-6.0%, macromolecular hyaluronic acid 0.01%-1.0%, low molecular hyaluronic acid 0.01%-1.0% and oligomeric hyaluronic acid 0.01% %-1.0%;
[0036] When the temperature of the emulsification pot drops to 65°C-75°C, add weighed glycerin, butylene glycol, macromolecular hyaluronic acid, low molecular hyaluronic acid and oligomeric hyaluronic acid in sequence, and stir until completely dissolved;
[0037] Step 3) Wait until the temperature of the emulsific...
Embodiment 1
[0040] Preparation of hyaluronic acid stock solution that can be introduced by microneedle:
[0041] Step 1) take the following raw materials by weight:
[0042]
[0043] Step 2) Weighing the water for injection, 1,2-pentanediol and thickener obtained in step 1), adding them to the emulsification pot in turn, cooling, and stirring until completely dissolved;
[0044] Step 3) When the temperature of the emulsification pot drops to 65°C, add the glycerin, butanediol, macromolecular hyaluronic acid, low molecular hyaluronic acid and oligomeric hyaluronic acid obtained in step 1) in sequence, and stir until completely dissolved;
[0045] Step 4) Wait until the temperature of the emulsification pot is lowered to 30°C to obtain the hyaluronic acid stock solution;
[0046] Step 4) Fill the hyaluronic acid stock solution obtained in step 3, and sterilize it with moist heat. The temperature of the moist heat sterilization is 110° C., and the sterilization time is 10 minutes, and a ...
Embodiment 2
[0049] Preparation of hyaluronic acid stock solution that can be introduced by microneedle:
[0050] Step 1) take the following raw materials by weight:
[0051]
[0052] Step 2) Weigh the water for injection, 1,2-pentanediol and thickener obtained in step 1), add them to the emulsification pot in turn, turn on the cooling, and stir until completely dissolved;
[0053] Step 3) When the temperature of the emulsification pot drops to 70°C, add the glycerin, butanediol, macromolecular hyaluronic acid, low molecular hyaluronic acid and oligomeric hyaluronic acid obtained in step 1) in sequence, and stir until completely dissolved;
[0054] Step 4) Wait until the temperature of the emulsification pot is lowered to 33°C to obtain the hyaluronic acid stock solution;
[0055] Step 4) Fill the hyaluronic acid stock solution obtained in step 3, and sterilize it with moist heat. The temperature of the moist heat sterilization is 120° C., and the sterilization time is 7 minutes, and a...
PUM
| Property | Measurement | Unit |
|---|---|---|
| molecular weight | aaaaa | aaaaa |
| molecular weight | aaaaa | aaaaa |
| molecular weight | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More