Preparation method of medical antibacterial hydrocolloid dressing

An antibacterial water and colloid technology, which is applied in medical formula, medical science, capsule delivery, etc., can solve the problems of hydrocolloid dressing loss of integrity, poor antibacterial properties of hydrocolloid dressing, slow absorption of exudate, etc., to improve medical performance, Effect of reducing rigidity, improving solubility and degradability

Inactive Publication Date: 2018-06-22
孙祎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present in this patented technology relates to making materials that have both good moisture retention properties (water) and ability to hold large amounts of liquid due to their high affinity towards living tissues or fluids. These materials may be useful in various applications such as drug delivery systems where they help deliver drugs directly into targeted areas inside patients' bodies without being diluted by blood flow during treatment procedures.

Problems solved by technology

This patented describes how current hydrogel dressings lose some important qualities during use due to breakdown over longer periods of wear (wear). These dressings lack anti-bacteria ability but may still cause harm if left untreated. Additionally, there was concern about adding too much bismuth oxide powder onto the dressings without causing it to stick out from them' surfaces even before being worn again. There were attempts to solve this issue through incorporating certain materials like silicon dioxanes together with other ingredients.

Method used

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  • Preparation method of medical antibacterial hydrocolloid dressing

Examples

Experimental program
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Effect test

example 1

[0028] Add 6g of sodium alginate into a beaker filled with 200mL of deionized water, stir with a magnetic stirrer at a speed of 500r / min until the sodium alginate dissolves, and obtain a sodium alginate solution with a mass fraction of 2%. Sodium acid was dissolved in 10g of deionized water to obtain an oxidation solution; put the above oxidation solution into a three-necked flask with a dropping funnel and a stirrer, start the stirrer, start stirring at a speed of 300r / min, and then add the above alginic acid The sodium solution was put into the dropping funnel, and the sodium alginate solution was added dropwise to the three-necked flask at a dropping rate of 4 mL / min. After the dropwise addition, the three-necked flask was protected from light, and reacted at room temperature for 20 hours to obtain the oxidation product solution; Add 4 mL of ethylene glycol to the above-mentioned oxidation product liquid, stop the reaction for 2 hours, then add 0.8 g of sodium chloride to ob...

example 2

[0030] Take 8g of sodium alginate and add it to a beaker containing 220mL of deionized water, stir with a magnetic stirrer at a speed of 520r / min until the sodium alginate dissolves, and obtain a sodium alginate solution with a mass fraction of 3%. Sodium acid was dissolved in 11g of deionized water to obtain an oxidation solution; put the above oxidation solution into a three-necked flask with a dropping funnel and a stirrer, start the stirrer, start stirring at a speed of 400r / min, and then add the above alginic acid The sodium solution was put into the dropping funnel, and the sodium alginate solution was added dropwise to the three-necked flask at a dropping rate of 5 mL / min. After the dropwise addition, the three-necked flask was protected from light, and reacted at room temperature for 22 hours to obtain the oxidation product solution; Add 4mL of ethylene glycol to the above-mentioned oxidation product solution, stop the reaction for 2.5h, then add 0.9g of sodium chloride...

example 3

[0032] Add 10g of sodium alginate into a beaker filled with 250mL of deionized water, stir with a magnetic stirrer at a speed of 550r / min until the sodium alginate dissolves, and obtain a sodium alginate solution with a mass fraction of 4%. Sodium acid was dissolved in 12g of deionized water to obtain an oxidation solution; put the above oxidation solution into a three-necked flask with a dropping funnel and a stirrer, start the stirrer, start stirring at a speed of 500r / min, and then add the above alginic acid The sodium solution was put into the dropping funnel, and the sodium alginate solution was added dropwise to the three-necked flask at a dropping rate of 6 mL / min. After the dropwise addition, the three-necked flask was protected from light, and reacted at room temperature for 24 hours to obtain the oxidation product solution; Add 5mL of ethylene glycol to the above-mentioned oxidation product solution, terminate the reaction for 3h, then add 1.0g of sodium chloride to o...

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Abstract

The invention discloses a preparation method of a medical antibacterial hydrocolloid dressing, and belongs to the technical field of dressing preparation. The main chemical components of a spider webused in the preparation method provided by the invention are glycine, alanine and a small part of serine together with other amino acid monomer protein molecular chains, and this specific protein canachieve a coagulation effect of platelets. In the preparation method provided by the invention, sodium alginate is easily dissolved in water, belongs to hydrophilic polymers, has strong water holdingcapacity, and obtains sodium alginate oxide containing aldehyde groups. The method reduces the rigidity of chains, improves the solubility and degradability of sodium alginate in an aqueous solution.In addition, due to the introduction of an active group namely an aldehyde group, the partially oxidized sodium alginate can form hydrogel through chemical crosslinking with polymer compounds with amino groups and other groups, and the sodium alginate oxide can still promote cell growth, thus improving the medical performance of the hydrocolloid dressing in treating wounds, improving the efficiency of absorbing exudate, and having a broad application prospect.

Description

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Claims

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Application Information

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Owner 孙祎
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