A method for removing inorganic salts and organic impurities in sucralose chlorinated liquid
A technology for sucralose and organic impurities, which is applied in the fields of organic chemistry, chemical instruments and methods, sugar derivatives, etc., can solve the problems of large production volume, high processing cost and high water content, so as to reduce the difficulty and cost and reduce the follow-up Handle pressure and avoid the effect of difficult crystallization and filtration
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Embodiment 1
[0028] In this embodiment, a method for removing inorganic salts and organic impurities in sucralose chlorinated liquid, the steps are as follows:
[0029] (1) 500mL of sucralose-6-acetate mixed solution is concentrated and distilled under reduced pressure at 90°C by a concentrating evaporator to form a viscous syrup; then add 500mL of ethyl acetate at 30°C and stir to precipitate crystals , to obtain the crystallized mixed material;
[0030] (2) The mixed material after the above-mentioned crystallization is cooled to room temperature and carries out suction filtration, obtains 47.5g black filter cake and 518ml ethyl acetate filtrate; Filter cake is washed with 30mL ethyl acetate, and after suction filtration, washing filtrate and ethyl acetate The ester filtrates are combined to concentrate and purify sucralose-6-acetate in subsequent processes;
[0031] (3) Add 100mL of methanol to soak the above-mentioned filter cake for 30min, and suction filter to obtain 35.8g of filter...
Embodiment 2
[0034] In this embodiment, a method for removing inorganic salts and organic impurities in sucralose chlorinated liquid, the steps are as follows:
[0035] (1) 500mL of sucralose-6-acetate mixed solution is concentrated and distilled under reduced pressure at 100°C by a concentrating evaporator to form a viscous syrup; then add 750mL of methyl acetate at 40°C and stir to precipitate crystals , to obtain the crystallized mixed material;
[0036] (2) The mixture material after the above-mentioned crystallization is cooled to room temperature and carries out suction filtration, obtains 43.6g black filter cake and 756mL methyl acetate filtrate; Filter cake is washed with 50mL methyl acetate, and after suction filtration, washing filtrate and methyl acetate The ester filtrates are combined to concentrate and purify sucralose-6-acetate in subsequent processes;
[0037] (3) Add 150mL of ethanol to soak the above-mentioned filter cake for 30min, and suction filter to obtain 32.3g of ...
Embodiment 3
[0040] In this embodiment, a method for removing inorganic salts and organic impurities in sucralose chlorinated liquid, the steps are as follows:
[0041] (1) 500mL sucralose-6-acetate mixed solution, concentrated and distilled under reduced pressure at 100°C by a concentrating evaporator to form a viscous syrup; then add 1000mL butyl acetate at 30°C, stir to precipitate crystals , to obtain the crystallized mixed material;
[0042] (2) The mixture material after the above-mentioned crystallization is cooled to room temperature and carries out suction filtration, obtains 45.1g black filter cake and 1008mL butyl acetate filtrate; Filter cake is washed with 50mL butyl acetate, and after suction filtration, washing filtrate and butyl acetate The ester filtrates are combined to concentrate and purify sucralose-6-acetate in subsequent processes;
[0043] (3) Add 150 mL of n-propanol to soak the above-mentioned filter cake for 30 minutes, and suction filter to obtain 34.5 g of fil...
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