Error-containing multi-character multi-interval positioning method based on marker locus genotypes

A technology of marking sites and positioning methods, applied in the field of molecular biology, can solve problems such as marker gene information errors, achieve accurate position and effect, accurate positioning, and save costs

Active Publication Date: 2018-06-22
SUIHUA UNIV
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  • Application Information

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Problems solved by technology

However, due to the precision of the instrument and other reasons, there are often errors in the marker gene information

Method used

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  • Error-containing multi-character multi-interval positioning method based on marker locus genotypes
  • Error-containing multi-character multi-interval positioning method based on marker locus genotypes
  • Error-containing multi-character multi-interval positioning method based on marker locus genotypes

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Embodiment Construction

[0032] The present invention provides an embodiment of a multi-trait multi-interval positioning method based on marker locus genotypes containing errors, in order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present invention, and make the present invention The above objects, features and advantages can be more obvious and understandable, and the technical solution in the present invention will be further described in detail below in conjunction with the accompanying drawings:

[0033] The present invention firstly provides a multi-trait multi-interval positioning method based on marker locus genotype containing errors, such as figure 1 shown, including:

[0034] S101, step 1, obtaining a molecular genetic map;

[0035] The data in this example comes from the work of Wittenburg et al. 2003, and this data set contains 305 F2 offspring. For the phenotype data, gallstone weight and high-density lipoprotein (High-densi...

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Abstract

The invention discloses an error-containing multi-character multi-interval positioning method based on marker locus genotypes. The method includes the steps: acquiring a molecular genetic map; determining a recombination rate gamma i between markers on two sides of an i marker interval and a recombination rate gamma il between a QTL (quantitative trait locus) and an upper marker locus within the i marker interval; generating a marker genotype and a QTL genotype according to the recombination rate gamma i between the markers on the two sides of the i marker interval and the recombination rate gamma il between the QTL (quantitative trait locus) and the upper marker locus within the i marker interval; acquiring the error-containing marker genotype according to a configured error rate; configuring parameter truth-values; acquiring phenotypic character observation values by a model; configuring initial values of parameters; iterating a parameter expression deducted by an EM(expectation maximization) algorithm until convergence; repeating the process for N times to obtain the average value of parameter estimation and mean square errors serving as target values. The method can effectively solve the problem that marker gene information contains errors, and the error rate of the marker gene information can be estimated.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to a multi-character and multi-interval positioning method based on marker site genotype containing errors. Background technique [0002] Human genetic diseases and crop phenotypic traits are almost all related to genetic genes. For a long time, for the convenience of research, most studies have ignored the situation that marker genotypes contain errors. However, due to the precision of the instrument and other reasons, there are often errors in the marker gene information. In order to prevent the occurrence of genetic diseases and make better use of favorable genes in germplasm resources, a new QTL mapping method was proposed. This analysis method can well solve the problem of multi-trait gene mapping with errors in marker genotypes. Contents of the invention [0003] The invention can well solve the problem that marker gene information contains errors, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/28G06F19/18G06F19/12
CPCG16B5/00G16B20/00G16B50/00
Inventor 佟良马春华孙晓霞邹大伟付丽耿艳秋
Owner SUIHUA UNIV
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