Knee joint orthotics capable of preventing lateral twisting force
A twisting force, knee joint technology, applied in the direction of drug devices, devices introduced into the body, hypodermic injection devices, etc., can solve the problems of aggravating knee joint injury, poor user experience, etc. The effect of preventing excessive distortion
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[0040] Example 1: Preparation of PEGylated oleanolic acid / Magnolol sustained-release agent
[0041] The PEGylated oleanolic acid was dissolved in a mixed solution of propylene glycol: water = 1:3 to prepare a 5 mg / mL solution. Dissolve magnolol in a mixed solution of propylene glycol: water = 1:3 to prepare a 5 mg / mL solution. The substrate was soaked in the above magnolol solution for 15 minutes, washed with water for 5 minutes, and then soaked in the PEGylated oleanolic acid solution for 15 minutes, and then washed with water for 5 minutes. Repeat this alternate deposition process to obtain a PEGylated oleanolic acid / Magnolol film.
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[0042] Example 2: In vitro release kinetics study
[0043] The PEGylated oleanolic acid / Magnolol film obtained in Example 1 was immersed in a phosphate buffer solution for an in vitro release experiment. Use 900 mL of pH 5.8 phosphate buffer solution as the release medium, rotate at 50 revolutions per minute, water bath temperature 37°C, sample 10 mL every 100 min, and supplement the release medium at the same temperature and volume at the same time, take out the sample release solution with 0.45 μm micro Filter through the pore filter membrane, and take the additional filtrate as the test sample solution. Detect the concentration of PEGylated oleanolic acid in the phosphate buffer solution by high performance liquid chromatography, and obtain the release kinetic curve of PEGylated oleanolic acid as figure 1 Shown. It can be seen that the PEGylated oleanolic acid is always released at a constant rate without sudden release and can be completely released.
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[0044] Example 3: Effectiveness test of pharmaceutical composition
[0045] There were 50 selected cases, aged 40-70 years old, 23 males and 27 females, 25 people in each group. Both groups had similar swelling of muscle and soft tissue and joint pain.
[0046] Treatment group: The drug sustained-release agent of this embodiment was applied to the affected area once a day for 7 consecutive days, and the effect on the 7th day and before treatment was observed.
[0047] Control group: apply a commercially available common joint pain relief cream to the affected area once a day for 7 consecutive days, and observe the effect on the 7th day and before treatment.
[0048] Evaluation method: There are three levels: cured, markedly effective, and ineffective. Cure: The swelling subsided completely and the pain disappeared; markedly effective: the swelling subsided significantly and the pain was alleviated; invalid: the swelling subsided was not obvious, and the pain was not relieved. Allergi...
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