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Composition of cannabidiol and hydantoin antiepileptic drug and use thereof

A technology of levulinyl urea and antiepileptic drugs, applied in the field of medicine, can solve the problems of reducing the percentage of tonic-clonic seizures, meaningless epilepsy treatment, and no obvious synergistic effect, so as to improve compliance and eliminate side effects Effect

Active Publication Date: 2018-07-06
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Patent application CN201280004572.6 discloses the use of cannabidiol (CBD) in combination with standard antiepileptic drugs acting through sodium or calcium channels at a dose higher than 300 mg / day for epilepsy, and discloses CBD in the examples The combination with valproate and phenobarbital, the combination of CBD and valproate can increase the latency of seizure onset and reduce the percentage of tonic-clonic seizures, but the combination of CBD and phenobarbital has little Obvious synergistic effect, the combination of the two is meaningless for the treatment of epilepsy

Method used

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  • Composition of cannabidiol and hydantoin antiepileptic drug and use thereof
  • Composition of cannabidiol and hydantoin antiepileptic drug and use thereof
  • Composition of cannabidiol and hydantoin antiepileptic drug and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Effect of the combination of CBD and levionylurea antiepileptic drugs on the therapeutic effect of epilepsy

[0043] Experimental Materials

[0044] Experimental animals: healthy male Wistar rats, weighing 75-110 g. Before the experiment, the animals were acclimatized to the experimental environment, cage, injection protocol and handling. The animals were kept at 21°C, 50% humidity and 12 hours of light, with free access to food and water.

[0045] experimental method

[0046] Rat partial seizure model establishment: The rat partial seizure model was induced by penicillin (Bostanci and Bagirici, 2006).

[0047] The experimental animals were divided into random groups, 20 in each group. The vehicle control or the test sample was injected intraperitoneally to the experimental animals. One week prior to this, a cannula was surgically implanted in the right ventricle of the animal under anesthesia. One hour after administration, penicillin (1000 IU / kg) was i...

Embodiment 2

[0066] Example 2 Animal experiments on the effect of the combination of CBD and levionylurea antiepileptic drugs on the side effects of drugs

[0067] Experimental animals: healthy male SD rats, 250-300g. Breeding conditions: room temperature 22±1°C, humidity 50±10%, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water. The experimental animals were randomly divided into 10 groups, 6 animals in each group.

[0068] Normal control group: normal experimental animals, given the same amount of solvent;

[0069] CBD and phenytoin combined administration group 1: animal model of epilepsy ignited by kainic acid, administered with 200mg phenytoin + 60mgCBD / day;

[0070] Combined administration of CBD and phenytoin group 2: animal model of epilepsy ignited by kainic acid, administered with 200 mg ph...

Embodiment 3

[0088] Example 3 Clinical experiments on the effect of the combination of CBD and PHT on the side effects of drugs

[0089] Subjects: 60 volunteers with partial epileptic seizures, male or female, were randomly divided into 2 groups, 20 people in each group, which were the control group and the experimental group.

[0090] Experimental group: 200mgPHT+600mgCBD / day;

[0091] Control group: PHT dosage 200mg / day;

[0092] Experimental method: According to the above-mentioned dosing regimen, the subjects were administered once a day for 12 consecutive months; the frequency of seizures and side effects during the 2nd, 4th, 6th, 8th, 10th, and 12th months were observed and recorded to treat The attack frequency in the first 2 months was used as the basic control.

[0093] Side effects: test blood routine, electrolytes and monitor blood drug concentration, record the side effects that occur at each observation point within 2 months; the side effects include ataxia, drowsiness, head...

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Abstract

The invention discloses a composition of cannabidiol and a hydantoin antiepileptic drug and use thereof. The composition comprises cannabidiol and a hydantoin antiepileptic drug or pharmaceutically acceptable salt thereof, especially a pharmaceutical composition of cannabidiol and phenytoin. The composition can achieve an unexpected synergistic treatment effect when used for treatment of epilepsy,especially partial epileptic seizure, also can alleviate or eliminate the side effect brought about by single use of cannabidiol or phenytoin, and improves the patient compliance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition of cannabidiol and levionylurea antiepileptic drugs, especially phenytoin, and its application in treating epilepsy, especially partial epileptic seizures. Background technique [0002] Epilepsy is a chronic brain disease caused by a variety of etiologies, characterized by recurrent, paroxysmal and transient central nervous system dysfunction caused by excessive discharge of brain neurons. [0003] Epilepsy occurs in people of any age, region and race, but the incidence is higher in children and adolescents. In recent years, with the aging of my country's population, the incidence of cerebrovascular diseases, dementia and neurodegenerative diseases has increased, and the incidence of epilepsy among the elderly has shown an upward trend. Epilepsy has a serious negative impact on individuals, families and society. Epilepsy causes great physical and psychological pai...

Claims

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Application Information

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IPC IPC(8): A61K31/4166A61K31/05A61K45/06A61P25/08A61P25/28
CPCA61K31/05A61K31/4166A61K45/06A61K2300/00
Inventor 张可谭昕常坦然金倩
Owner HANYI BIO TECH CO LTD
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