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A traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application

A technology for osteoporosis and composition, applied in traditional Chinese medicine composition and its preparation, the application field of traditional Chinese medicine composition and its preparation method, can solve problems such as belching, constipation and the like

Active Publication Date: 2021-11-23
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are certain defects in calcium carbonate tablets, such as inorganic calcium neutralizes gastric acid, which can cause belching, constipation, etc.

Method used

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  • A traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application
  • A traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application
  • A traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 is used for preventing or treating the preparation of osteoporosis Chinese medicine composition

[0022] (1) Preparation of Polygonatum water extract: Polygonatum decoction pieces are decocted twice with 12 times the weight of distilled water, each time for 2 hours, the decoction liquid is combined, filtered, concentrated under reduced pressure to a viscous shape, and finally vacuum-dried to obtain Polygonatum water Extract, yield rate is 50.1%;

[0023] (2) Preparation of Rhizoma Drynariae Alcoholic Extract: Shred Drynariae decoction pieces, use 10 times the weight of 55% (v / v) ethanol to heat and reflux extract twice, each time for 2 hours, combine the extracts, filter, and concentrate to Viscous, and finally vacuum-dried to obtain drynaria alcoholic extract with a yield of 7.8%;

[0024] (3) Preparation of the water extract of Astragalus membranaceus: cut the decoction pieces of Astragalus membranaceus into pieces, decoct 2 times with 8 times the weight...

Embodiment 2

[0027] Embodiment 2 is used for the preparation of prevention or treatment osteoporosis Chinese medicine composition

[0028] (1) Preparation of Polygonatum water extract: Polygonatum decocting pieces are decocted twice with 10 times the weight of distilled water, each time for 1.5h, the decoction liquid is combined, filtered, concentrated under reduced pressure to a viscous shape, and finally vacuum-dried to obtain Polygonatum water extract;

[0029](2) Preparation of Rhizoma Rhizoma Drynariae Alcoholic Extract: Cut Rhizoma Rhizoma Rhizoma Drynaria into pieces, heat and reflux extraction with 8 times the weight of 55% (v / v) ethanol for 2 times, each time for 1.5h, combine the extracts, filter, and concentrate to a viscous shape, and finally vacuum-dried to obtain the drynaria alcoholic extract;

[0030] (3) Preparation of the water extract of Astragalus membranaceus: cut the decoction pieces of Astragalus membranaceus into pieces, decoct twice with 12 times the weight of dis...

Embodiment 3

[0033] Embodiment 3 is used for the preparation of prevention or treatment osteoporosis Chinese medicine composition

[0034] (1) Preparation of Polygonatum water extract: Polygonatum decocting pieces are decocted twice with 10 times the weight of distilled water, each time for 2.5 hours, the decoction liquid is combined, filtered, concentrated under reduced pressure to a viscous shape, and finally vacuum-dried to obtain Polygonatum water extract;

[0035] (2) Preparation of Rhizoma Drynariae Alcoholic Extract: Shred Drynariae decoction pieces, heat and reflux extraction with 10 times the weight of 60% (v / v) ethanol for 2 times, each time for 2.5 hours, combine the extracts, filter, and concentrate to a viscous shape, and finally vacuum-dried to obtain the drynaria alcoholic extract;

[0036] (3) Preparation of the water extract of Astragalus membranaceus: cut the decoction pieces of Astragalus membranaceus into pieces, decoct twice with 10 times the weight of distilled water...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application. The traditional Chinese medicine composition is composed of oyster shell powder, Polygonatum water extract, black ant water extract, Radix Astragali water extract, Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Drynariae alcohol extract according to 3-5:0.5-1.5:0.5-1.5:1-3: 1‑3 weight ratio composition. This formula nourishes the kidneys and softens the liver, strengthens the tendons and bones, replenishes qi and invigorates the spleen, dispels blood stasis and unblocks the collaterals. It is suitable for fatigue, low back pain or general bone pain, and tetany, etc., so as to prevent and treat osteoporosis. effect. It has been proved by experiments that the administration of the traditional Chinese medicine composition of the present invention in an animal model of osteoporosis established by a low-calcium diet can increase the bone density of the animal model of a low-calcium diet, and can regulate ALP and BUN of the animal model of a low-calcium diet, and affect creatinine. and phosphorus metabolism, the middle and low doses of the traditional Chinese medicine composition can increase the level of osteocalcin in animal models with low calcium diet. The proposal of the present invention provides a new and effective technical means for preventing and treating osteoporosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for preventing or treating osteoporosis and its preparation method and application. The invention belongs to the technical field of medicine. Background technique [0002] With the aging population in my country, the incidence of osteoporosis is increasing year by year. Epidemiological studies have shown that in 2006, about 69.44 million people over the age of 50 suffered from osteoporosis, and about 210 million people had low bone mass. The World Health Organization (WHO) survey shows that osteoporosis jumped from the seventh largest disease in the world in 2003 to the second largest disease that seriously endangers human health in 2009. Therefore, how to prevent and treat osteoporosis has become an important problem to be solved in clinical practice. Osteoporosis is a progressiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P19/10A61K35/618A61K35/64
CPCA61K36/8969A61K35/618A61K35/63A61K36/126A61K36/481A61K2300/00
Inventor 杨宝峰杨磊许超千王宁
Owner HARBIN MEDICAL UNIVERSITY