Application of rifamycin-quinazine ketone coupling molecule

Abstract

The invention discloses application of a rifamycin-quinazine ketone coupling molecule or a three-dimensional isomer thereof or hydrate thereof or a deuterated material thereof, ester thereof, a solvent compound thereof, a crystal form thereof, a metabolic product thereof or pharmaceutically acceptable salt thereof or a pro-drug thereof in resisting nontuberculous mycobacteria. The rifamycin-quinazine ketone coupling molecule has a structure as shown in formula I. The rifamycin-quinazine ketone coupling molecule disclosed by the inention or the three-dimensional isomer thereof or hydrate thereof or the deuterated material thereof, ester thereof, the solvent compound thereof, the crystal form thereof, the metabolic product thereof or the pharmaceutically acceptable salt thereof or the pro-drug thereof can effectively resist nontuberculous mycobacteria, and can be used for treating infection caused by human nontuberculous mycobacteria.

Description

technical field [0001] The invention relates to the application of a rifamycin-quinazinone coupling molecule, which belongs to the technical field of medicine. Background technique [0002] Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria, refers to bacteria other than mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae (Mycobacterium leprae). of mycobacteria. There are many ways to classify mycobacteria. From the perspective of clinical guidance, NTM can be simply divided into rapidly growing mycobacteria (RGM) and slowly growing mycobacteria (SGM). Medication choices provide useful information. Given the popularity of solid cultures, this sorting method can be implemented without special techniques and additional manipulations, making it practical. RGM can obtain macroscopic colonies within 3-7 days on solid medium, while SGM needs several weeks. The most common clinically valuable RGMs include Mycobacterium abscessus, Mycobacterium...

AI Technical Summary

Problems solved by technology

Due to the different species of mycobacteria that cause NTM infection, with different growth rates and characteristics, and different resistance to antimicrobial drugs, long-term antimicrobial treatment is often required, with low success rate and significant side effects

Especially in recent years, the resistance of NTM to existing drugs has been increasing, and the efficacy of existing drugs has been further reduced

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