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Adhesives and bonding systems for vitreous or retinal surgical incisions

A surgical incision and retinal technology, applied in surgery, ophthalmic surgery, surgical adhesives, etc., can solve problems such as ciliary body detachment, weak resistance, fundus blood vessel bleeding, etc., and achieve the effect of reducing the impact

Active Publication Date: 2021-05-07
沈阳百奥医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is no secondary injury in the above two methods, since the scleral tunnel incision and minimally invasive incision have good resistance to the force perpendicular to the sclera, but their resistance to the force from the orbit and eyelid is weak, often Leakage of vitreous body, silicone oil, gas and other eye contents can cause serious conjunctivitis, conjunctival ulcer, choroiditis, etc. At the same time, the leakage of intraocular objects can cause transient low intraocular pressure, which can cause sudden hemorrhage of fundus blood vessels, retinal, Choroid, ciliary body detachment, etc. At the same time, serious complications such as endophthalmitis are likely to occur due to the incomplete closure of scleral incision

Method used

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  • Adhesives and bonding systems for vitreous or retinal surgical incisions
  • Adhesives and bonding systems for vitreous or retinal surgical incisions
  • Adhesives and bonding systems for vitreous or retinal surgical incisions

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Accurately weigh 1.5g of PLGA-PEG-PLGA thermosensitive hydrogel, whose phase transition temperature is 34°C, add sterile purified water to 10mL under sterile conditions, slowly dissolve at 4°C for 7 days, and prepare sterile thermosensitive hydrogel Glue solution, dispensed into the syringe of a disposable sterile 1mL syringe; dispense Kefeng Medical Adhesive e cyanoacrylic acid into the injection needle of a sterile 1mL syringe, and store it at 4°C with a 1ml syringe for later use.

Embodiment 2

[0027] New Zealand white rabbits were used as experimental subjects, and the adhesive system prepared in Example 1 was used for research, and physiological saline was used as a control group.

[0028] New Zealand white rabbits were anesthetized by intramuscular injection of pentobarbital sodium (30mg / kg) and Sumianxin (0.1ml / kg). After the rabbit muscle reflex disappeared, the eye surface was anesthetized and disinfected. At a distance of 1cm from the eyeball at 12 o'clock and 4mm from the limbus, puncture the bulbar conjunctiva with a sterile disposable syringe needle (25G), and insert the needle vertically at the pre-set incision position at 12 o'clock of the eyeball , to prepare the fundus surgery incision surgery model.

[0029] The adhesive system prepared in Example 1 is used to inject biomaterials into the incision of the bulbar conjunctiva through the bulbar conjunctiva. The head of the syringe touches the incision of the sclera. Slowly inject medical glue to bond the ...

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Abstract

The invention provides an adhesive for vitreous or retinal surgical incisions, comprising medical glue and a temperature-sensitive hydrogel compounded on the medical glue, and the temperature-sensitive hydrogel has a phase transition temperature of 34°C ~35°C. The present invention also provides an adhesive system for vitreous or retinal surgical incisions, comprising: a syringe, the needle of the syringe is filled with medical glue, and the barrel of the syringe is filled with a temperature-sensitive hydrogel solution. The phase transition temperature of the temperature-sensitive hydrogel is 34°C to 35°C. The present invention first injects medical glue into the surgical incision, closes the surgical incision, prevents bacteria from invading and keeps the incision flat, and then solidifies the temperature-sensitive hydrogel on the medical glue in situ to maintain the stable pressure inside the vitreous body and reduce the impact on the fundus. Impact. Moreover, both the medical glue and the temperature-sensitive hydrogel are biodegradable substances, which gradually biodegrade in the human body, and do not need to be taken out by secondary surgery, and will not cause secondary damage.

Description

technical field [0001] The invention relates to the technical field of treatment of eye-related diseases, in particular to an adhesive for vitreous or retinal surgical incisions and an adhesive system. Background technique [0002] Retina and vitreous diseases are common diseases in ophthalmology. The disease is located in the posterior segment of the eyeball, often causing large irreversible damage to vision. Ocular lesions caused by a variety of degenerative diseases and multisystem diseases. At present, common fundus diseases include diabetic retinopathy, age-related macular degeneration, retinal vein occlusion and so on. At present, the surgery for large logarithmic retinal and vitreous diseases requires scleral incision to remove the vitreous tissue near the retina or diseased, so as to provide a certain operating space for the treatment of the retina. [0003] At present, the methods for dealing with scleral fundus surgery incisions mainly include the following metho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00A61F9/007
CPCA61F9/007A61F9/00736A61L24/0005A61L24/0031A61L24/0042A61L24/046A61L24/08A61L2300/412C08L71/02C08L5/08
Inventor 王卓实郑玉强
Owner 沈阳百奥医疗器械有限公司