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Amantadine hydrochloride-containing oral drug composition

A technology of amantadine hydrochloride and composition, which is applied in the field of medicine and can solve problems such as the bitter taste of oral medicines

Inactive Publication Date: 2018-08-03
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As a molecular-level encapsulation carrier of drugs, liposomes provide an idea to solve the problem of oral drug bitterness, but correspondingly as a liquid suspension system, it is prepared into a solid preparation, and the taste-masking effect after reconstitution still needs further research

Method used

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  • Amantadine hydrochloride-containing oral drug composition
  • Amantadine hydrochloride-containing oral drug composition
  • Amantadine hydrochloride-containing oral drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1 Preparation of amantadine hydrochloride liposome oral liquid (unit: g)

[0074]

[0075]

[0076] Preparation Process:

[0077] Step 1: Take the amantadine hydrochloride bulk drug and pulverize it, pass it through a 100-mesh sieve, and set aside;

[0078] Step 2: Take an appropriate amount of lipid solvent ethanol, dissolve the lipid complex, and the antioxidant butylated hydroxyanisole, and heat it in a water bath to 60°C to form the lipid phase of the blank liposome, keep it warm, and set aside;

[0079] Step 3: Take 70% of the prescription amount in purified water, dissolve ammonium sulfate at a concentration of 0.1M, sucrose, and citric acid, adjust the pH of the solution to 6.0-6.5 with 0.1M NaOH solution, and heat it in a water bath to 60°C to form a blank liposome Water phase, heat preservation, stirring, standby;

[0080] Step 4: Take the blank liposome lipid phase solution obtained in step 2, reverse the rotation direction of the water phas...

Embodiment 2

[0085] The preparation of embodiment 2 amantadine hydrochloride oral granules (unit: g)

[0086]

[0087] Preparation Process:

[0088] Step 1: Take the amantadine hydrochloride bulk drug and pulverize it, pass it through a 100-mesh sieve, and set aside;

[0089] Step 2: Take an appropriate amount of lipid solvent ethanol, dissolve the lipid complex, and the antioxidant butylated hydroxyanisole, and heat it in a water bath to 60°C to form the lipid phase of the blank liposome, keep it warm, and set aside;

[0090] Step 3: Take 70% of the prescription amount in purified water, dissolve ammonium sulfate at a concentration of 0.1M, sucrose, and citric acid, adjust the pH of the solution to 6.0-6.5 with 0.1M NaOH solution, and heat it in a water bath to 60°C to form a blank liposome Water phase, heat preservation, stirring, standby;

[0091] Step 4: Take the blank liposome lipid phase solution obtained in step 2, reverse the rotation direction of the water phase with a syring...

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Abstract

The invention relates to an amantadine hydrochloride-containing oral drug composition. The inventor makes an amantadine hydrochloride raw material medicine be wrapped into an internal water phase of liposome by adopting a mode that ammonium sulfate actively carries a drug progressively according to the specific bitterness problem, so that the amantadine hydrochloride-containing oral drug composition effectively avoids direct contact with an oral cavity and achieves a good bitterness covering effect; furthermore, by a spray drying technology, the amantadine hydrochloride and liposome mixed suspension is prepared into dried powder, so that the composition is easy to carry; during application, pure water is added for mixing suspension.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral pharmaceutical composition containing amantadine hydrochloride, a preparation method and application thereof. Background technique [0002] Influenza (abbreviated as influenza) is an acute respiratory infection caused by influenza virus, and it is also a disease with strong contagion and fast transmission speed. It is mainly spread through droplets in the air, person-to-person contact or contact with contaminated items. Typical clinical symptoms are: sudden onset of high fever, general pain, significant fatigue and mild respiratory symptoms. Generally, autumn and winter are the high-incidence period, and the complications and death caused by it are very serious. The disease is caused by influenza virus, which can be divided into three types: A (A), B (B), and C (C). Type A virus often undergoes antigenic variation, is highly contagious, spreads rapidly, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/13A61K47/10A61K47/12A61K47/24A61P31/16
CPCA61K9/127A61K9/0095A61K9/1278A61K31/13A61K47/10A61K47/12A61K47/24A61P31/16
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司