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A kind of preparation method of gold nanorod

A technology for gold nanorods and gold seeds, which is applied in the field of preparation of gold nanorods, can solve the problems of low preparation efficiency, high consumption of a highly toxic ligand, cetyltrimethylammonium bromide, etc., and achieves improved process efficiency. , the effect of reducing toxicity and saving production costs

Active Publication Date: 2020-08-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, each step of the configuration method of the prior art is relatively independent, and there is a shortcoming that the preparation efficiency is not high, and the amount of the highly toxic ligand cetyltrimethylammonium bromide (CTAB) is too much.

Method used

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  • A kind of preparation method of gold nanorod
  • A kind of preparation method of gold nanorod
  • A kind of preparation method of gold nanorod

Examples

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Embodiment 1

[0039] The preparation method of the gold nanorod of the present embodiment comprises the following steps:

[0040] (1) Prepare the growth solution, successively dissolve 0.7g cetyltrimethylammonium bromide (CTAB), 0.155g sodium oleate (NaOL) into 25mL water, add 0.6mL 4mM silver nitrate aqueous solution, 25mL 1mM HAuCl 4 aqueous solution, and the growth solution was equally divided into 5 parts;

[0041] (2) To prepare the gold seed solution, quickly add 1 mL of 0.006M NaHB to one of the solutions in step (1) 4 , stirred rapidly for 2 minutes, and left to stand for 30 minutes to prepare the gold seed solution;

[0042] (3) After 1.5 hours, add 0.042mL of 37% concentrated hydrochloric acid to the other 4 parts of the growth solution in step (1), add 25μL of 0.045M ascorbic acid (AA) solution after 15 minutes, and quickly add 0.006 mL, 0.012mL, 0.024mL, 0.040mL of gold seed solution, left at room temperature for 12h to obtain gold nanorods (GNR) with a single distribution.

Embodiment 2

[0044] The preparation method of the gold nanorod of the present embodiment comprises the following steps:

[0045] (1) To prepare the growth solution, dissolve 0.28g cetyltrimethylammonium bromide (CTAB), 0.062g sodium oleate (NaOL) into 10mL water successively, add 0.96mL 4mM silver nitrate aqueous solution, 10mL 1mM HAuCl 4 aqueous solution, the growth solution was equally divided into 2 parts;

[0046] (2) To prepare the gold seed solution, quickly add 1 mL of 0.006M NaHB to one of the solutions in step (1) 4 , stirred rapidly for 2 minutes, and left to stand for 30 minutes to prepare the gold seed solution;

[0047] (3) After 1.5h, add 0.06mL of 37% concentrated hydrochloric acid to another solution in step (1), add 25μL of 0.045M ascorbic acid (AA) solution after 15min, add 0.080mL respectively after 30s quickly The gold seed solution was allowed to stand at room temperature for 12 hours to obtain gold nanorods (GNRs) with a single distribution.

[0048] Figure 1 to...

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Abstract

The invention discloses a preparation method of a gold nanorod. The preparation method comprises the following steps that (1), cetyl trimethyl ammonium bromide and oleate are mixed to prepare a solution, and then a soluble silver ion solution and a HAuCl4 aqueous solution are sequentially added, so as to obtain a growth solution, and the growth solution is equally divided into at least two parts;(2), a NaHB4 aqueous solution is rapidly added in one growth solution in the step (1) to obtain a gold seed solution after the solution is rapidly stirred and left the solution to stand; and (3), an acid solution and an ascorbic acid solution are added to the other growth solutions in the step (1), the gold seed solution which is in the step (2) is rapidly added in the solution after the solutionis stirred and left the solution to stand. According to the method, the preparation process of the gold seed solution is simplified, and the process efficiency is improved; and the oleate is introduced in the whole process, and the use of high-toxicity ligand cetyl trimethyl ammonium bromide (CTAB) is reduced, the production cost is also reduced while the toxicity is reduced.

Description

technical field [0001] The invention relates to the field of manufacturing gold nanorods, in particular to a preparation method of gold nanorods. Background technique [0002] Gold nanorods have a wide range of applications in many fields. For example, in medical diagnosis and treatment, due to the advantages of stable properties, adjustable optical properties, and easy surface functionalization of gold nanorods, gold nanorods can be used as a platform to form biomolecular detection or medical imaging reagents with many fluorescent structures. In addition, gold nanorods have a wide range of applications in drug delivery and photothermal therapy, which will promote the development of precision medicine. [0003] In terms of molecular probes, since the resonance peak of gold nanorods is in the near-back outer region, its scattering signal is also in the near-infrared region, so it can take advantage of the characteristics that infrared rays can easily penetrate biological tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00
CPCB22F9/24B82Y40/00
Inventor 李东升张汉杰杨德仁
Owner ZHEJIANG UNIV