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Application of dioscin in preparation of drugs for inhibiting osteoarthritis

A technology for osteoarthritis and diosgenin, which is applied in the field of medicine and can solve the problems that diosgenin has not been reported.

Inactive Publication Date: 2018-08-17
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the results of diosgenin in the treatment of osteoarthritis and the preparation and application of osteoarthritis drugs have not been reported.

Method used

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  • Application of dioscin in preparation of drugs for inhibiting osteoarthritis
  • Application of dioscin in preparation of drugs for inhibiting osteoarthritis
  • Application of dioscin in preparation of drugs for inhibiting osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1 Animal model establishment

[0024] All animal care and experimental procedures were performed in accordance with the Animal Care and Use Committee (IACUC) of the Laboratory Animal Science Center of Dalian Medical University. 12-week-old specific pathogen-free (SPF) male Sprague-Dawley rats were selected for the study. The animal room environment is set at a temperature of (22-25°C), with a 12-hour / 12-hour day-to-night cycle, and the animals can freely drink water and food in the cage. The rats have a week to adapt to the new environment, and then continue as follows 4 weeks.

[0025] 2 Construction and intervention of osteoarthritis model

[0026] The rats were randomly divided into two groups: group 1 (n=8) only received knee joint exposure (blank group); group 2 (n=24) received intra-articular MIA injection. After intraperitoneal injection of 10% chloral hydrate (5mL / kg) for anesthesia. Intra-articular cartilage damage was induced by intra-articular injection o...

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PUM

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Abstract

The invention discloses application of dioscin in preparation of drugs for inhibiting osteoarthritis, and particularly relates to dioscin as a natural steroid saponins compound capable of relieving osteoarthritis symptoms and slowing down the process of arthritis. The dioscin has high application prospect in preparation of drugs for inhibiting osteoarthritis. Particularly, the dioscin has excellent application prospect in preparation of various drugs including drugs for relieving and reversing joint injury, drugs for relieving and reversing cartilage injury of articular surfaces, drugs for resisting inflammation of bony articular surfaces, drugs for resisting oxidation, drugs for resisting endoplasmic reticulum stress, drugs for resisting chondrocyte apoptosis and drugs for protecting andmaintaining the steady state of cartilage metabolism by a mode of down-regulating Wnt / beta-catenin signal channel and up-regulating PPAR-gamma.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of diosgenin in the preparation of medicines for inhibiting osteoarthritis. Background technique [0002] Osteoarthritis is a disease caused by progressive destruction of articular cartilage and subchondral bone tissue, manifested as joint stiffness, pain, and deformation. About 2.37 million people worldwide suffer from osteoarthritis, and it will inevitably increase with the aging of the population. Osteoarthritis has a great impact on the quality of life of patients and there is still no effective treatment. The current drug therapy is mainly aimed at relieving the pain of osteoarthritis, and joint replacement surgery, as an immediate treatment, cannot avoid the disadvantages of implant wear and revision. Therefore, it is very important to find a drug that can relieve the symptoms of osteoarthritis and slow down the progress of arthritis. Dioscin is a natura...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P19/02A61P29/00
CPCA61K31/7048A61P19/02A61P29/00
Inventor 刘谟震孙慧君陆佳玮彭金咏张庭玮
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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