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A kind of Pickering emulsion type cosmetics with stable sod enzyme particles and its preparation process

A Pickering emulsion and enzyme particle technology, applied in cosmetic preparations, cosmetics, cosmetic preparations, etc., to achieve the effect of uniform size, delaying skin aging, and small radius

Active Publication Date: 2020-10-20
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, we consider replacing metal particles with biologically active substances. Currently, there are few reports on the use of biologically active substances to stabilize Pickering emulsion-type cosmetic formulations.

Method used

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  • A kind of Pickering emulsion type cosmetics with stable sod enzyme particles and its preparation process
  • A kind of Pickering emulsion type cosmetics with stable sod enzyme particles and its preparation process
  • A kind of Pickering emulsion type cosmetics with stable sod enzyme particles and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Add 10 mg of unmodified SOD enzyme freeze-dried powder to 5 mL (pH=7.8) of phosphate buffer, stir until completely dissolved to form a buffer containing SOD enzyme; add 0.5 μL of glutaraldehyde to the above SOD enzyme In the buffer solution, mix the solution evenly to avoid bubbles, and let it stand at 20°C for 1 hour;

[0028] 2) After the reaction is over, transfer the reaction solution into a watch glass and place it at a temperature of 37.5°C and an air flow rate of 260-300m 3 In the constant temperature oven of / h, after drying for 8 hours, obtain the SOD enzyme granule solid powder of glutaraldehyde modification;

[0029] 3) Dissolve the solid powder obtained in 2) with 5 mL of deionized water, and add 1 mL of white oil;

[0030] 4) Use a high-speed disperser to homogenize the solution obtained in 3) at a speed of 15000-20000 rpm for 1-3 minutes to obtain a Pickering emulsion with stable SOD enzyme particles.

[0031] See attached for its effect figure 1 . (a...

Embodiment 2

[0033] 1) Add 10 mg of unmodified SOD enzyme freeze-dried powder to 5 mL (pH=7.8) phosphate buffer, stir until completely dissolved to form a buffer containing SOD enzyme; add 0.5 μL glutaraldehyde to the above SOD enzyme-containing buffer In the buffer solution, mix the solution evenly to avoid bubbles, and let it stand at 20°C for 1 hour;

[0034] 2) After the reaction is over, transfer the reaction solution into a watch glass and place it at a temperature of 37.5°C and an air flow rate of 260-300m 3 In the constant temperature oven of / h, after drying for 8 hours, obtain the SOD enzyme granule solid powder of glutaraldehyde modification;

[0035] 3) The solid powder obtained in 2) is subjected to scanning electron microscope sample preparation, and placed under a scanning electron microscope for observation.

[0036] See attached for its effect figure 2 . SOD enzyme particles with a particle size of about 100 nm were observed.

Embodiment 3

[0038] 1) Add 10 mg of unmodified SOD enzyme freeze-dried powder to 5 mL (pH=7.8) phosphate buffer, stir until completely dissolved to form a buffer containing SOD enzyme; add 0.5 μL glutaraldehyde to the above SOD enzyme-containing buffer In the buffer solution, mix the solution evenly to avoid bubbles, and let it stand at 20°C for 1 hour;

[0039] 2) After the reaction is over, transfer the reaction solution into a watch glass and place it at a temperature of 37.5°C and an air flow rate of 260-300m 3 In the constant temperature oven of / h, after drying for 8 hours, obtain the SOD enzyme granule solid powder of glutaraldehyde modification;

[0040] 3) Spread the solid powder obtained in 2) evenly on a glass slide with an area of ​​5mm×5mm, moisten it with a small amount of deionized water, and place it at a temperature of 37.5°C and an air flow rate of 260-300m 3 / h in a constant temperature oven to dry;

[0041] 4) Place the glass slide obtained in 3) on the bottom of the ...

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Abstract

A Pickering emulsion cosmetic with SOD enzyme particle stabilization and a preparation process thereof. Glutaraldehyde is added to the phosphate buffer solution containing SOD enzyme, wherein SOD enzyme: glutaraldehyde=20:1 (mass ratio), a cross-linking reaction occurs, and then the reaction solution is dried at a constant temperature to generate a certain particle size Size and wettability of nanoparticles. The enzyme nanoparticles are formulated into 0.1%-0.5% SOD enzyme particle aqueous solution, which is added to a certain proportion of the oil phase, and then the basic ingredients of common cosmetics such as essence, glycerin, sodium hyaluronate and xanthan gum are added, After high-speed homogenization, dispersion and emulsification, it is made into a cosmetic emulsion. The invention has the advantages of simplicity, low cost, long time for stabilizing the emulsion, and at the same time, the enzyme particles for stabilizing the emulsion have biological activity, etc., and has good application prospects in the industry of enzyme-containing cosmetics.

Description

technical field [0001] The invention relates to a surfactant, especially a cosmetic containing SOD enzyme and a preparation method thereof. Background technique [0002] Most of the emulsions currently on the market are stabilized by surfactants. Surfactants rely on the nature of one end as a hydrophilic group and the other end as a hydrophobic group, which can be oriented at the oil-water interface, thereby stabilizing water-in-oil or water-in-water. Oily emulsion. However, most of the surfactants are petrochemical products, and long-term use has certain irritation to the mucous membranes. Especially when they are added to cosmetics, they are sensitizing to the skin and even cause cancer. Using them as cosmetic ingredients will cause Many users have allergies, inflammation, redness, etc. Moreover, the surfactant-stabilized emulsion has a short storage time and is easy to deteriorate, which seriously affects the preservation and use of cosmetics, especially the bioactive i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/66A61K8/06A61K8/02A61Q19/00A61Q19/08
CPCA61K8/0245A61K8/062A61K8/66A61K2800/413A61K2800/57A61Q19/00A61Q19/08
Inventor 孟涛彭志廖思杨薛龙辉
Owner SOUTHWEST JIAOTONG UNIV
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