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Application of magnetic field confinement device in preparation of products for adjuvant chemotherapy

A chemotherapeutic drug and therapeutic technology, applied in biochemical equipment and methods, using electricity/wave energy to treat microorganisms, tumors/cancer cells, etc., can solve the problems of aggravating drug side effects, prolongation, and no extremely weak magnetic field

Active Publication Date: 2021-05-18
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The increase in the course of treatment and the replacement of drugs will prolong or even aggravate the pain caused by the side effects of drugs
Moreover, even broad-spectrum chemotherapy drugs do not have a significant therapeutic effect on all tumors
At present, there is no research on the application of extremely weak magnetic fields in tumor therapy

Method used

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  • Application of magnetic field confinement device in preparation of products for adjuvant chemotherapy
  • Application of magnetic field confinement device in preparation of products for adjuvant chemotherapy
  • Application of magnetic field confinement device in preparation of products for adjuvant chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1. Magnetic field confinement increases the sensitivity of tumor cells to cisplatin

[0030] Test cells:

[0031] 4T1 cells are mouse breast cancer cell lines.

[0032] SH-SY5Y cells are human neuroblastoma cell lines.

[0033] B16 cells are mouse melanoma cell lines.

[0034] OCM-1 cells are human low-invasive choroidal melanoma cell lines.

[0035] MUM-2B cells are human invasive choroidal melanoma cell lines.

[0036] N2a cells are mouse neuroblastoma cell lines.

[0037] The above cells can be purchased from Concord Cell Bank and ATCC Cell Bank in the United States.

[0038] Cisplatin, cis-Diammineplatinum(II) dichloride, is a product of Sigma-Aldrich (USA).

[0039] Cisplatin is a class of broad-spectrum antineoplastic drugs. It can chemically add to DNA nucleotides, interfere with DNA replication, block tumor cell division, and eventually lead to cell apoptosis.

[0040] 1. Experimental grouping and methods

[0041] They were divided into magnetic...

Embodiment 2

[0055] Example 2. Magnetic field confinement increases the sensitivity of tumor cells to pentafluorouracil

[0056] 1. The test cells, experimental grouping and method, and tumor growth inhibition efficiency measurement are carried out with reference to the implementation case 1. For each cell, the concentration of cisplatin in the medium is set as image 3 is shown on the abscissa.

[0057] Pentafluorouracil, 5-fluorouracil, is a product of Sigma-Aldrich (USA).

[0058] Pentafluorouracil can interfere with the synthesis of DNA and RNA, and is a class of cell cycle blocking antineoplastic drugs.

[0059] 2. Experimental results

[0060] In the two groups of magnetic field confinement and geomagnetic field control, the growth inhibition results of pentafluorouracil on 4T1 cells, SH-SY5Y cells, B16 cells, OCM-1 cells, MUM-2B cells, and N2a cells are as follows: image 3 shown. The results showed that magnetic field constraints had no or only weak effects on the sensitivity o...

Embodiment 3

[0062] Example 3. Magnetic field confinement increases the sensitivity of tumor cells to cytarabine

[0063] 1. The test cells, experimental grouping and method, and tumor growth inhibition efficiency measurement are carried out with reference to the implementation case 1. For each cell, the concentration of cisplatin in the medium is set as Figure 4 is shown on the abscissa.

[0064] Arabinoside cytosine is a product of Sigma-Aldrich (USA).

[0065] Cytarabine can interfere with DNA synthesis, block cell cycle progression in S phase, and inhibit tumor proliferation.

[0066] 2. Experimental results

[0067] In the two groups of magnetic field constraint and geomagnetic field control, the results of cytarabine on the proliferation inhibition of 4T1 cells, SH-SY5Y cells, B16 cells, OCM-1 cells, MUM-2B cells, and N2a cells are as follows: Figure 4 shown. The results showed that 4T1, OCM-1 and N2a cells were more sensitive to cytarabine, and a lower drug concentration could...

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Abstract

The invention discloses a new application of a magnetic field confinement device. The new use is specifically the application of the magnetic field confinement device in the following applications: the application in the preparation of products for adjuvant chemotherapy, or the application in the preparation of products for enhancing the sensitivity of tumor cells to chemotherapy drugs. Experiments have shown that under magnetic field constraints (0‑5μT), the sensitivity of melanoma cells, choroidal melanoma cells, neuroblastoma cells, and breast cancer cells to chemotherapy drugs will be significantly improved. Due to the constraints of the magnetic field, it is a physical environment that is easy to simulate, and it is very convenient to realize the treatment of tumors, and the magnetic field can penetrate biological tissues, enabling non-invasive treatment. Therefore, the method of the present invention can not only improve the efficacy of chemotherapy, but also provide a simple and non-invasive treatment environment.

Description

technical field [0001] The invention belongs to the field of biophysics and relates to the application of magnetic field confinement equipment in preparing products for auxiliary chemotherapy. Background technique [0002] At present, chemotherapy has been widely used in the treatment of tumors. Chemotherapy drugs block the metabolism and cell division of tumor cells, inhibit the proliferation of tumor cells, and even induce the apoptosis of tumor cells, thereby reducing the number of tumor cells and achieving the purpose of controlling tumor development. However, patients who receive systemic chemotherapy must suffer from severe side effects of chemotherapy, such as vomiting and bradykinesia. This seriously affects the quality of life of patients. The side effects of chemotherapy are one of the biggest clinical problems in cancer treatment. In addition, the use of chemotherapy drugs has various limitations. The dosage of each course of treatment is constrained by the to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N13/00C12N5/09
CPCC12N5/0693C12N13/00C12N2529/00
Inventor 莫炜川胡平东刘缨赫荣乔
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES