3D printing method for magnesium alloy-polymer composite biodegradable biological scaffold

Abstract

The invention discloses a 3D printing method for a magnesium alloy-polymer composite biodegradable biological scaffold. The method comprises the following steps: making a biodegradable magnesium alloymaterial into biodegradable magnesium alloy fibers of different mechanical properties and different diameters, and enabling the biodegradable magnesium alloy fibers to penetrate through a nozzle of acoaxial 3D printing head; adding a biodegradable polymer material into a hot-melt chamber on the inner side of the coaxial 3D printing head, and totally extruding the biodegradable magnesium alloy fibers and the molten biodegradable polymer from the nozzle after the biodegradable polymer is molten, so as to form biodegradable magnesium alloy-polymer composite reinforcing fibers; finally, performing 3D printing under control of a 3D printing system according to a scaffold structure in individualized design, thereby obtaining the magnesium alloy-polymer composite reinforced biodegradable biological scaffold. According to the method disclosed by the invention, by virtue of a manner of compounding the polymer on an outer surface of biodegradable magnesium alloy fibers at a low temperature, the mechanical and structural properties of the printed biodegradable biological scaffold are enhanced, and the degradation time of the magnesium alloy is effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of multi-material composite 3D printing, and in particular relates to a 3D printing method of a magnesium alloy-polymer composite degradable bio-stent. Background technique [0002] Biodegradable absorbent materials in vivo are an important direction for the development of biomaterials. At present, biodegradable absorbent materials in clinical applications are mainly polymers and certain ceramic materials, such as polylactic acid, calcium phosphate, etc., but due to the low strength of polymer materials 1. The poor plasticity and toughness of ceramic materials limit their wide application. In recent years, the research on a new generation of medical metal materials with biodegradable properties, mainly represented by biodegradable magnesium alloys, has received special attention. This new type of medical metal material cleverly uses the characteristics of magnesium alloys that are prone to corrosion and deg...

AI Technical Summary

Problems solved by technology

Currently commonly used metal implants are biologically inert materials, which are fixed and left in human tissues for a long time, which may cause inflammation. Moreover, if they need to be removed after healing, a second operation will be required, which increases the cost of treatment and the pain of patients.

However, the magnesium alloy degrades too quickly after being implanted into the human body, which has certain disadvantages. For example, it takes a certain time for tissue healing. If the magnesium alloy degrades quickly, its biomechanical effect cannot be fully exerted, resulting in poor tissue healing and even treatment failure; moreover, Magnesium alloy degrades too fast, resulting in a large amount of products in the degradation process that accumulate around the tissue, cannot be absorbed quickly, and will also affect the recovery of tissue function

[0004] With the continuous promotion and application of personalized 3D printing technology in the medical industry, the demand for personalized 3D printing of magnesium alloy prostheses is becoming more and more prominent. Using traditional 3D printing methods cannot solve the problems of high melting point, high flammability and explosion of magnesium alloys. , some studies have used magnesium alloy powder mixed with polymers to print implants, but the magnesium alloy powder has greatly weakened the structural mechanical properties of the magnesium alloy. How to make it safe, reliable and stable in the field of 3D printing Better application has become an urgent industry problem to be solved

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