Preparation method of standard quartz powder used for copying silicosis model

A quartz dust, standard technology, applied in the field of preparation of medical model materials, can solve the problems of unreachable dispersion, imitation, and weak pathogenicity, and achieve the effects of simple operation, promotion of research progress, and easy industrial production

Inactive Publication Date: 2018-09-07
ZHEJIANG ACAD OF MEDICAL SCI
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Problems solved by technology

The quartz dust produced by Sigma-Aldrich is artificially synthesized silica, which is relatively weak in pathogenicity, and its dispersion does not meet the requirement of 5 μm, accounting for about 99%. It cannot simulate the actual situation of workers exposed to dust. During the action process, dust with a diameter greater than 5 μm is often blocked in the upper respiratory tract, while inhalable dust less than 5 μm can enter the alveoli and cause pulmonary fibrosis

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  • Preparation method of standard quartz powder used for copying silicosis model
  • Preparation method of standard quartz powder used for copying silicosis model
  • Preparation method of standard quartz powder used for copying silicosis model

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Embodiment Construction

[0016] 1. Preparation of Quartz Dust

[0017] (1) Selection of quartz raw materials

[0018] Choose 200g of natural quartz crystal block, its purity is 99.28%, that is, free SiO 2 The mass content is 99.28%. Generally speaking, the purer the quartz, the better. After preliminary processing and crushing, the crystal block becomes rough crystal sand, and the rough crystal sand generally has a particle size of 2-5mm.

[0019] (2) Grinding of crystal sand

[0020] Put 1 part of coarse crystal sand and 7 parts of agate balls (that is, the mass ratio is 1:7) into a 500ml agate grinding jar. Ratio of 4:2:1:1:1 for joining. Then add distilled water to the agate grinding jar to a level about 1cm from the mouth of the jar. The weights of the four agate jars should be equal. If they are not equal, use distilled water to adjust them to be equal to maintain a balanced state during grinding. After tightening the sealing cap of the agate jar, place it on a ball mill and grind at a spee...

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Abstract

The invention discloses a preparation method of standard quartz powder used for copying a silicosis model. Natural crystals are adopted as raw materials of the quartz powder, and the preparation method includes the steps of putting quartz crystals into an agate ball milling tank for ball milling for 6 days, adding distilled water, conducting standing, then screening out a suspension containing quartz powder in demanded grain size, conducing drying and sedimentation after the suspension is completely subjected to standing, and then obtaining the quartz powder meeting requirements. The preparedquartz powder can be provided for researchers to copy animal models and cell silicosis models; by using the standard quartz powder with the uniform specification, experiment results among different researchers have comparability, and research on silicosis pathogenesis and treatment drugs is facilitated. The method is easy to operate and is easily applied to industrial production.

Description

technical field [0001] The invention relates to a method for preparing medical model materials, in particular to a method for preparing standard quartz dust for replicating animal silicosis models. Background technique [0002] Pneumoconiosis is the most widespread and serious occupational disease that endangers the health of dust-exposed workers, and it is the focus and difficulty in the prevention and control of occupational diseases in my country. According to the National Health and Family Planning Commission, by the end of 2016, a total of 831,246 cases of pneumoconiosis had been reported in my country, accounting for about 90% of all occupational diseases, mainly silicosis and coal workers' pneumoconiosis. We sorted out the reported case data of occupational diseases from the National Health and Family Planning Commission (formerly the Ministry of Health) from 2010 to 2016, and found that the number of reported cases of pneumoconiosis has increased year by year, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/12A61K33/14
CPCA61K33/14C01B33/12C01P2002/72C01P2004/61
Inventor 冯玲芳楼建林陈钧强陈日萍蒋兆强郭心念夏海玲朱丽瑾童延贾君麟
Owner ZHEJIANG ACAD OF MEDICAL SCI
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