Biochip reaction process online self-diagnosis device

Abstract

The invention discloses a biochip reaction process online self-diagnosis device, which comprises a CCD camera and an image processor, wherein the CCD camera is used for obtaining static images of a biochip before the liquid reaction in a biochip reaction cavity; the image processor is used for processing the static images, performing self-diagnosis before the reaction, liquid addition action self-diagnosis and liquid discharge action self-diagnosis, and evaluating the mixing effect of the liquid in the biochip reaction cavity. The device is applicable to various biochips; the specific marks and scales are set according to the reaction process and time sequences of the biochip; an applicable liquid sensing method is introduced; the applicable image processing method is selected; the self-diagnosis of the biochip operation process can be realized.

Description

technical field [0001] The invention relates to biochip technology, in particular to an online self-diagnosis device for biochip reaction process. Background technique [0002] In recent years, biochip technology has been applied more and more in medical testing experiments, and researchers hope to complete complex chemical or biological reactions through the microstructure in biochips. The basic units in the chip mainly include microstructures such as cavities, pipes, micro valves, and micro pumps. These units are passive devices and need to be controlled by an external drive mechanism that is used in conjunction with them, so as to realize the flow of reactive substances in the chip. Movement (such as flow, mixing, dilution, heating or cooling, etc.). The biochips currently in use in the market all adopt an open-loop design, that is, there is no feedback signal for the execution effect of the control mechanism after executing the control command, and usually rely on impro...

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Problems solved by technology

The biochips currently in use in the market all adopt an open-loop design, that is, there is no feedback signal for the execution effect of the control mechanism after executing the control command, and usually rely on improving the reliability of the structure, the level of processing technology and the quality of manufacturing to ensure every action of the chip If the chip itself or the external drive mechanism is defective or fails, it will cause distortion or error in the reaction process in the chip. Since there is no feedback information, the system will still run according to the preset steps, resulting in inspection or experimental results. Incorrect, and it is not clear where the problem lies, which has buried hidden dangers for the reliability of the system

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