Method for determining transfer rate of isothiazolinone preservative in wet wipe during simulated use

The technology of isothiazolinone and isothiazoline is applied in the technical field of detection of isothiazolinone preservatives in towels, and can solve the problems of allergic inflammation, sensitization cytotoxicity and neurotoxicity, and infant health effects. , to achieve good effect, low price, and reduce the interference of sample matrix

Active Publication Date: 2018-09-18
安徽省产品质量监督检验研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The isothiazolinone preservatives commonly used in wet wipes are often sensitizing, cytotoxic and neurotoxic, which may cause allergic inflammation and other consequences, especially for infants and young children. Health is more likely to have serious impacts

Method used

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  • Method for determining transfer rate of isothiazolinone preservative in wet wipe during simulated use
  • Method for determining transfer rate of isothiazolinone preservative in wet wipe during simulated use
  • Method for determining transfer rate of isothiazolinone preservative in wet wipe during simulated use

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preparation example Construction

[0063]6. Preparation of isothiazolinone spiked wet wipe samples: Weigh commercially available wet wipes that have been determined to contain no isothiazolinone, place them in an oven at 95±2°C for 2 hours, soak the dried wet wipes In 100mL of 5 kinds of isothiazolinone mixed standard solution of specific concentration for 20min, take out the wet wipe in the constant temperature and humidity laboratory, the temperature inside the constant temperature and humidity laboratory is 23±2℃, and the relative humidity is 50±5%. Lift the corner of the wet tissue and hang it, and drain it naturally until the wet tissue no longer drips, weigh the mass of the drained wet tissue, and the deviation from the mass of the wet tissue before drying should not exceed 5%, and prepare a sample of the spiked wet tissue. Carry out simulated use experiment, measure the content of isothiazolinone in the sample and calculate the transfer rate of simulated use of isothiazolinone.

[0064] The mixed standar...

Embodiment 1

[0071] Example 1: Dry the commercially available wet wipes that are determined not to contain isothiazolinones, and soak them in a high-concentration mixed standard solution of 5 kinds of isothiazolinones to prepare wet wipe samples with high spiked levels. According to the concentration range of isothiazolinones in commercially available wet wipe samples, the concentration of the corresponding mixed standard solution of five kinds of isothiazolinones for high-concentration soaking is 20.0 mg / kg. Using the above method, after measuring the actual isothiazolinone spiked concentration of the wet tissue samples with high spiked level and the concentration of isothiazolinone after simulated use, the experimental results for calculating the transfer rate of simulated use are shown in Table 4.

Embodiment 2

[0072] Example 2: Dry the commercially available wet wipes that have been determined to be free of isothiazolinones, and soak them in a mixed standard solution of 5 kinds of isothiazolinones at medium concentrations to prepare wet wipe samples at the middle spiked level. According to the concentration range of isothiazolinones in commercially available wet wipe samples, the concentration of the corresponding mixed standard solution of five kinds of isothiazolinones for medium-concentration soaking is 10.0 mg / kg. Using the above method, after measuring the actual isothiazolinone spiked concentration of the mid-spiked level wet tissue sample, the concentration of isothiazolinone after simulated use, and the experimental results for calculating the transfer rate of simulated use are shown in Table 4.

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Abstract

The invention discloses a method for determining the transfer rate of an isothiazolinone preservative in a wet wipe during simulated use. The method is characterized in that the contents of isothiazolinone in a wet wipe before and after simulated use are detected, and the transfer rate of the isothiazolinone preservative in the wet wipe during the simulated use is calculated so as to reflect the transfer condition of the isothiazolinone along with the liquid during the use of the wet wipe, ie., the possible retention degree of the isothiazolinone on the skin; and the standard wet wipe sample simultaneously containing five kinds of isothiazolinones is prepared, and the samples with the high standard level, the medium standard level and the low standard level are subjected to detection analysis and summarization induction. According to the present invention, with the application of the method to detect the transfer rate of the isothiazolinone preservative in the actual wet wipe during the simulated use, the detection result is consistent with the standard wet wipe sample; and the method has characteristics of accurate quantitation and good reproducibility, and can provide the technical support for the quality and safety supervision of daily necessities.

Description

technical field [0001] The invention relates to the technical field of detection of isothiazolinone preservatives in wet wipes, in particular to 2-methyl-4-isothiazolin-3-one (MIT), 5-chloro-2-methyl -4-isothiazolin-3-one (CMIT), 1,2-benzisothiazolin-3-one (BIT), 2-n-octyl-4-isothiazolin-3-one (OIT) and 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) mimics the method used for the determination of transfer rates. Background technique [0002] The vast majority of consumers who use wet wipes in my country mainly use wet wipes for hand and mouth cleaning or infant hygiene, and they will not rinse after cleaning with wet wipes. The preservatives in wet wipes will transfer and reside on the skin superior. The isothiazolinone preservatives commonly used in wet wipes are often sensitizing, cytotoxic and neurotoxic, and may cause allergic inflammation and other consequences, especially for infants and young children. Health is more likely to have a serious impact. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N5/00G01N30/02G01N30/06G01N1/28
CPCG01N1/286G01N5/00G01N30/02G01N30/06
Inventor 何汉翔姚帮本郭佳佳童宁汪龙余包磊
Owner 安徽省产品质量监督检验研究院
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